Hemostatic biomarkers associated with postpartum hemorrhage: a systematic review and meta-analysis.
Journal
Blood advances
ISSN: 2473-9537
Titre abrégé: Blood Adv
Pays: United States
ID NLM: 101698425
Informations de publication
Date de publication:
10 10 2023
10 10 2023
Historique:
accepted:
30
05
2023
received:
06
03
2023
medline:
23
10
2023
pubmed:
12
6
2023
entrez:
12
6
2023
Statut:
ppublish
Résumé
Postpartum hemorrhage (PPH) is a leading cause of maternal morbi-mortality. Although obstetric risk factors are well described, the impact of predelivery hematologic and hemostatic biomarkers remains incompletely understood. In this systematic review, we aimed to summarize the available literature on the association between predelivery hemostatic biomarkers and PPH/severe PPH. Searching MEDLINE, EMBASE, and CENTRAL databases from inception to October 2022, we included observational studies on unselected pregnant women without bleeding disorder reporting on PPH and on predelivery hemostatic biomarkers. Two review authors independently performed title, abstract and full-text screening, upon which quantitative syntheses of studies reporting on the same hemostatic biomarker were conducted, calculating the mean difference (MD) between women with PPH/severe PPH and controls. A search on 18 October 2022 yielded 81 articles fitting our inclusion criteria. The heterogeneity between studies was considerable. With regard to PPH, the estimated average MD in the investigated biomarkers (platelets, fibrinogen, hemoglobin, Ddimer, activated partial thromboplastin time, and prothrombin time) were not statistically significant. Women who developed severe PPH had lower predelivery platelets than controls (MD = -26.0 109/L; 95% confidence interval, -35.8 to -16.1), whereas differences in predelivery fibrinogen concentration (MD = -0.31 g/L; 95% confidence interval, -0.75 to 0.13) and levels of factor XIII or hemoglobin were not statistically significant in women with and without severe PPH. Predelivery platelet counts were, on average, lower in women with severe PPH compared with controls, suggesting the potential usefulness of this biomarker for predicting severe PPH. This trial was registered at the International Prospective Register of Systematic Reviews as CRD42022368075.
Identifiants
pubmed: 37307172
pii: 496269
doi: 10.1182/bloodadvances.2023010143
pmc: PMC10562765
doi:
Substances chimiques
Hemostatics
0
Hemoglobins
0
Fibrinogen
9001-32-5
Biomarkers
0
Types de publication
Meta-Analysis
Systematic Review
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
5954-5967Informations de copyright
© 2023 by The American Society of Hematology. Licensed under Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0), permitting only noncommercial, nonderivative use with attribution. All other rights reserved.
Références
J Thromb Haemost. 2020 Jun;18(6):1310-1319
pubmed: 32176833
JAMA Netw Open. 2022 Feb 1;5(2):e2147046
pubmed: 35113162
Stat Methods Med Res. 2018 Jun;27(6):1785-1805
pubmed: 27683581
Sci Rep. 2021 Sep 28;11(1):19238
pubmed: 34584125
Int J Gynaecol Obstet. 2022 Dec;159(3):790-795
pubmed: 35307829
PLoS One. 2019 Nov 13;14(11):e0225123
pubmed: 31721799
Int J Nurs Stud. 2018 Mar;79:114-121
pubmed: 29223625
J Obstet Gynaecol. 2005 Jul;25(5):440-4
pubmed: 16183576
Am J Obstet Gynecol. 2015 Jul;213(1):76.e1-76.e10
pubmed: 25731692
Br J Obstet Gynaecol. 1993 Apr;100(4):327-33
pubmed: 8494833
Br J Haematol. 2022 May;197(4):482-488
pubmed: 35266559
Rev Bras Ginecol Obstet. 2021 Feb;43(2):113-118
pubmed: 33511619
J Health Popul Nutr. 2008 Jun;26(2):232-40
pubmed: 18686556
J Thromb Haemost. 2020 Aug;18(8):1813-1838
pubmed: 32356929
J Matern Fetal Neonatal Med. 2021 Nov;34(21):3586-3590
pubmed: 31736418
Am J Transl Res. 2022 Jun 15;14(6):4146-4153
pubmed: 35836856
BMC Pregnancy Childbirth. 2021 Apr 26;21(1):332
pubmed: 33902475
Cureus. 2022 Jul 25;14(7):e27238
pubmed: 36039215
PLoS One. 2019 Apr 4;14(4):e0214840
pubmed: 30947286
J Obstet Gynaecol. 2016 May;36(4):473-5
pubmed: 26399479
Arch Gynecol Obstet. 2019 Feb;299(2):421-430
pubmed: 30511192
J Matern Fetal Neonatal Med. 2019 Aug;32(16):2633-2637
pubmed: 29455618
J Obstet Gynaecol Res. 2021 Aug;47(8):2565-2576
pubmed: 34002432
Anaesthesia. 2021 Jan;76(1):61-71
pubmed: 32845522
J Matern Fetal Neonatal Med. 2022 Aug;35(15):2829-2835
pubmed: 32777966
Int J Obstet Anesth. 2021 Aug;47:103174
pubmed: 34023143
N Engl J Med. 2018 Jul 05;379(1):32-43
pubmed: 29972751
Environ Sci Pollut Res Int. 2022 May;29(25):37543-37555
pubmed: 35066843
Obstet Gynecol. 2019 Dec;134(6):1308-1316
pubmed: 31764744
BJOG. 2019 May;126(6):737-743
pubmed: 30554474
Eur J Obstet Gynecol Reprod Biol. 2022 Aug;275:31-36
pubmed: 35714502
East Afr Med J. 2008 Feb;85(2):64-71
pubmed: 18557249
Am J Perinatol. 2017 Sep;34(11):1135-1141
pubmed: 28683512
Reprod Sci. 2022 Apr;29(4):1102-1110
pubmed: 34993930
Eur J Haematol. 2022 Nov;109(5):566-575
pubmed: 36059200
BMC Pregnancy Childbirth. 2019 Jul 29;19(1):269
pubmed: 31357932
Kurume Med J. 2021 Jul 21;66(2):107-114
pubmed: 34135198
Obstet Gynecol. 2020 Jun;135(6):1338-1344
pubmed: 32459425
Cureus. 2019 Oct 7;11(10):e5854
pubmed: 31754588
Transfusion. 2015 Dec;55(12):2799-806
pubmed: 26246160
BMC Pregnancy Childbirth. 2017 Jan 10;17(1):17
pubmed: 28068990
J Matern Fetal Neonatal Med. 2017 Jul;30(14):1704-1708
pubmed: 27549985
Eur J Clin Nutr. 1998 Jan;52(1):65-70
pubmed: 9481535
Semin Fetal Neonatal Med. 2020 Oct;25(5):101129
pubmed: 32782215
PLoS One. 2022 Feb 15;17(2):e0263731
pubmed: 35167600
Br J Anaesth. 2012 Dec;109(6):851-63
pubmed: 23075633
Int J Gynaecol Obstet. 2012 Feb;116(2):143-7
pubmed: 22114785
BJOG. 2021 Jan;128(1):46-53
pubmed: 32575159
Anesth Analg. 2017 Aug;125(2):523-532
pubmed: 28277324
J Matern Fetal Neonatal Med. 2022 Dec;35(25):7353-7359
pubmed: 34304671
J Perinat Med. 2016 Jul 1;44(5):551-6
pubmed: 26756085
J Obstet Gynaecol. 2010;30(7):694-6
pubmed: 20925612
Biology (Basel). 2022 Dec 29;12(1):
pubmed: 36671746
Ann N Y Acad Sci. 2019 Aug;1450(1):47-68
pubmed: 30994929
Acta Obstet Gynecol Scand. 2006;85(1):49-55
pubmed: 16521680
Br J Anaesth. 2015 Jul;115(1):99-104
pubmed: 25788657
Acta Obstet Gynecol Scand. 2016 May;95(5):555-64
pubmed: 26846870
Int J Gynaecol Obstet. 2012 May;117(2):134-9
pubmed: 22356761
Am J Perinatol. 2022 May 27;:
pubmed: 35253114
Am J Obstet Gynecol MFM. 2021 Sep;3(5):100395
pubmed: 33992832
J Matern Fetal Neonatal Med. 2012 Nov;25(11):2454-7
pubmed: 22708721
J Clin Med. 2021 Aug 31;10(17):
pubmed: 34501395
BMC Pregnancy Childbirth. 2016 Jan 25;16:17
pubmed: 26810108
BMC Pregnancy Childbirth. 2011 Nov 28;11:97
pubmed: 22123123
Thromb Res. 2012 Apr;129(4):e1-7
pubmed: 22018996
Anaesthesia. 2022 Jun;77(6):700-711
pubmed: 35194779
Int J Gynaecol Obstet. 2021 Apr;153(1):89-94
pubmed: 33341932
J Matern Fetal Neonatal Med. 2020 Nov;33(22):3740-3745
pubmed: 30836810
Int J Gynaecol Obstet. 2022 May;157(2):353-358
pubmed: 34165794
J Anesth. 2021 Apr;35(2):197-205
pubmed: 33507393
J Matern Fetal Neonatal Med. 2022 Dec;35(25):8426-8433
pubmed: 34551661
J Family Med Prim Care. 2017 Oct-Dec;6(4):739-743
pubmed: 29564255
Ann N Y Acad Sci. 2019 Aug;1450(1):69-82
pubmed: 31148191
J Perinat Med. 2017 May 24;45(4):427-435
pubmed: 27442353
BMJ Open. 2021 Oct 4;11(10):e050815
pubmed: 34607867
PLoS One. 2019 Oct 31;14(10):e0224579
pubmed: 31671143
Indian J Crit Care Med. 2019 Nov;23(11):503-508
pubmed: 31911740
Stat Med. 2003 Sep 15;22(17):2693-710
pubmed: 12939780
Am J Obstet Gynecol. 2012 Jan;206(1):76.e1-7
pubmed: 21963102
J Gynecol Obstet Hum Reprod. 2021 Nov;50(9):102168
pubmed: 34033967
J Thromb Haemost. 2012 Jul;10(7):1451-3
pubmed: 22520037
J Thromb Haemost. 2021 Nov;19(11):2873-2883
pubmed: 34339085
Int J Gynaecol Obstet. 2002 Nov;79(2):93-100
pubmed: 12427391
Turk J Obstet Gynecol. 2018 Sep;15(3):165-170
pubmed: 30202626
Int J Obstet Anesth. 2014 Nov;23(4):365-70
pubmed: 25262279
Br J Anaesth. 1997 Jun;78(6):678-83
pubmed: 9215019
Am J Obstet Gynecol MFM. 2021 Sep;3(5):100404
pubmed: 34048966
Arch Gynecol Obstet. 2016 Oct;294(4):745-51
pubmed: 26899183
Am J Obstet Gynecol MFM. 2021 Jul;3(4):100368
pubmed: 33831587