Evaluation of Fetal Cardiac Functions in Preeclampsia: Does the Severity or Proteinuria Affect Fetal Cardiac Functions?
fetal cardiac function
preeclampsia
proteinuria
tissue Doppler imaging
Journal
Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine
ISSN: 1550-9613
Titre abrégé: J Ultrasound Med
Pays: England
ID NLM: 8211547
Informations de publication
Date de publication:
Oct 2023
Oct 2023
Historique:
revised:
24
04
2023
received:
27
02
2023
accepted:
08
05
2023
medline:
20
9
2023
pubmed:
13
6
2023
entrez:
13
6
2023
Statut:
ppublish
Résumé
To compare the fetal cardiac functions in preeclampsia and control group, and determine whether the severity or amount of proteinuria affects fetal cardiac functions. This prospective case-control study involves 48 pregnant women with preeclampsia and 48 healthy women. Pulsed wave Doppler, M-mode, and tissue Doppler imaging were used to measure the cardiac function between the 32 and 34 gestational weeks in each group. All Doppler indices and cardiac function parameters were also compared in subgroups with mild and severe preeclampsia and between subgroups with proteinuria >3 g/24 hours and <3 g/24 hours. Decreased diastolic function (decreased E, A, E', and A' values in mitral/tricuspid valves and increased isovolumetric relaxation time) and decreased systolic functions (decreased mitral and tricuspid annular plane systolic excursion and S' value in mitral/tricuspid valves) were detected in the preeclampsia group. Decreased tricuspid E value in severe preeclampsia compared with mild preeclampsia was shown in the present study. Preeclampsia may cause changes in systolic and diastolic functions in the fetal heart. Subclinical functional changes of these fetuses can be detected earlier and more sensitively with the help of tissue Doppler imaging. Biventricular diastolic functional changes are more prominent in preeclamptic cases with proteinuria >3 g/24 hours.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2415-2424Informations de copyright
© 2023 American Institute of Ultrasound in Medicine.
Références
ACOG Practice Bulletin. Diagnosis and management of preeclampsia and eclampsia. Number 33, January 2002. American College of Obstetricians and Gynecologists. Int J Gynaecol Obstet 2002; 77:67-75.
Abalos E, Cuesta C, Grosso AL, Chou D, Say L. Global and regional estimates of preeclampsia and eclampsia: a systematic review. Eur J Obstet Gynecol Reprod Biol 2013; 170:1-7.
ACOG Practice Bulletin. ACOG Practice Bulletin No. 202: gestational hypertension and preeclampsia. Obstet Gynecol 2019; 133:1.
Gilbert JS, Ryan MJ, LaMarca BB, Sedeek M, Murphy SR, Granger JP. Pathophysiology of hypertension during preeclampsia: linking placental ischemia with endothelial dysfunction. Am J Physiol Heart Circ Physiol 2008; 294:H541-H550.
Leijnse JEW, de Heus R, de Jager W, et al. First trimester placental vascularization and angiogenetic factors are associated with adverse pregnancy outcome. Pregnancy Hypertens 2018; 13:87-94.
Silva DM, Marreiro Ddo N, Moita Neto JM, et al. Oxidative stress and immunological alteration in women with preeclampsia. Hypertens Pregnancy 2013; 32:304-311.
Tsakiridis I, Giouleka S, Arvanitaki A, et al. Gestational hypertension and preeclampsia: an overview of national and international guidelines. Obstet Gynecol Surv 2021; 76:613-633.
Tranquilli AL, Dekker G, Magee L, et al. The classification, diagnosis and management of the hypertensive disorders of pregnancy: a revised statement from the ISSHP. Pregnancy Hypertens 2014; 4:97-104.
Tanacan A, Fadiloglu E, Beksac MS. The importance of proteinuria in preeclampsia and its predictive role in maternal and neonatal outcomes. Hypertens Pregnancy 2019; 38:111-118.
Guida JP, Parpinelli MA, Surita FG, Costa ML. The impact of proteinuria on maternal and perinatal outcomes among women with pre-eclampsia. Int J Gynaecol Obstet 2018; 143:101-107.
Mateus J, Newman R, Sibai BM, et al. Massive urinary protein excretion associated with greater neonatal risk in preeclampsia. AJP Rep 2017; 7:e49-e58.
van der Tuuk K, Holswilder-Olde Scholtenhuis MA, Koopmans CM, et al. Prediction of neonatal outcome in women with gestational hypertension or mild preeclampsia after 36 weeks of gestation. J Matern-Fetal Neonatal Med 2015; 28:783-789.
Crispi F, Valenzuela-Alcaraz B, Cruz-Lemini M, Gratacós E. Ultrasound assessment of fetal cardiac function. Australas J Ultrasound Med 2013; 16:158-167.
Balli S, Kibar AE, Ece I, Oflaz MB, Yilmaz O. Assessment of fetal cardiac function in mild preeclampsia. Pediatr Cardiol 2013; 34:1674-1679.
Akil A, Api O, Oten Can E, et al. Does preeclampsia have any adverse effect on fetal heart? J Matern-Fetal Neonatal Med 2016; 29:2312-2315.
Zhou Q, Ren Y, Yan Y, Chu C, Gui Y, Li X. Fetal tissue Doppler imaging in pregnancies complicated with preeclampsia with or without intrauterine growth restriction. Prenat Diagn 2012; 32:1021-1028.
Youssef L, Miranda J, Paules C, et al. Fetal cardiac remodeling and dysfunction is associated with both preeclampsia and fetal growth restriction. Am J Obstet Gynecol 2020; 222:79.e1-79.e9.
Hoodbhoy Z, Mohammed N, Rozi S, et al. Cardiovascular dysfunction in children exposed to preeclampsia during fetal life. J Am Soc Echocardiogr 2021; 34:653-661.
Nahum Sacks K, Friger M, Shoham-Vardi I, et al. Prenatal exposure to preeclampsia as an independent risk factor for long-term cardiovascular morbidity of the offspring. Pregnancy Hypertens 2018; 13:181-186.
Api O, Emeksiz MB, Api M, Ugurel V, Unal O. Modified myocardial performance index for evaluation of fetal cardiac function in pre-eclampsia. Ultrasound Obstet Gynecol 2009; 33:51-57.
Lindheimer MD, Kanter D. Interpreting abnormal proteinuria in pregnancy: the need for a more pathophysiological approach. Obstet Gynecol 2010; 115:365-375.
Oluklu D, Menekse Beser D, Uyan Hendem D, et al. Assessment of fetal cardiac morphology and functional changes in early-onset and late-onset fetal growth restriction. Int J Gynaecol Obstet 2023; 161:241-249.
Tugrul Ersak D, Oluklu D, Uyan Hendem D, et al. The assessment of fetal cardiac output in maternal hypothyroidism under levothyroxine treatment. Echocardiography 2022; 39:1434-1438.
Menekse Beser D, Oluklu D, Uyan Hendem D, et al. Fetal echocardiographic evaluation before and after nifedipine treatment in preterm labor. Echocardiography 2022; 39:1245-1251.
Goncu Ayhan S, Turgut E, Ozden Tokalioglu E, et al. Post-COVID-19 fetal cardiac evaluation in moderate infection group of pregnant women. J Clin Ultrasound 2022; 50:630-635.
Turgut E, Sakcak B, Uyan Hendem D, Oluklu D, Goncu Ayhan S, Sahin D. Decreased fetal cardiac output in pregnant women with severe SARS-Cov-2 infection. Echocardiography 2022; 39:803-810.
Oluklu D, Kara O, Turgut E, Goncu Ayhan S, Yildirim M, Sahin D. Evaluation of fetal cardiac morphology and functions in pregnant women with familial Mediterranean fever. Echocardiography 2022; 39:606-611.
Faul F, Erdfelder E, Lang AG, Buchner A. G*power 3: a flexible statistical power analysis program for the social, behavioral, and biomedical sciences. Behav Res Methods 2007; 39:175-191.
Semmler J, Garcia-Gonzalez C, Sanchez Sierra A, Gallardo Arozena M, Nicolaides KH, Charakida M. Fetal cardiac function at 35-37 weeks' gestation in pregnancies that subsequently develop pre-eclampsia. Ultrasound Obstet Gynecol 2021; 57:417-422.
Steegers EA, von Dadelszen P, Duvekot JJ, Pijnenborg R. Pre-eclampsia. Lancet 2010; 376:631-644.
Umezuluike BS, Anikwe CC, Nnachi OC, Iwe BCA, Ifemelumma CC, Dimejesi IBO. Correlation of platelet parameters with adverse maternal and neonatal outcomes in severe preeclampsia: a case-control study. Heliyon 2021; 7:e08484.
Jia RZ, Qian YJ, Zhang X, Ding HJ, Wu HQ, Shao KM. Contribution of dysfunction of maternal hemodynamics to renal impairment in preeclampsia. Gynecol Obstet Investig 2013; 76:95-99.
Cornelis T, Odutayo A, Keunen J, Hladunewich M. The kidney in normal pregnancy and preeclampsia. Semin Nephrol 2011; 31:4-14.
Newman MG, Robichaux AG, Stedman CM, et al. Perinatal outcomes in preeclampsia that is complicated by massive proteinuria. Am J Obstet Gynecol 2003; 188:264-268.