Axially Chiral Cannabinoids: Design, Synthesis, and Cannabinoid Receptor Affinity.

Cannabinoids Endocannabinoids Receptors, Cannabinoid Ligands Cannabidiol Cannabinol

Journal

Journal of the American Chemical Society
ISSN: 1520-5126
Titre abrégé: J Am Chem Soc
Pays: United States
ID NLM: 7503056

Informations de publication

Date de publication:
28 06 2023
Historique:
medline: 29 6 2023
pubmed: 14 6 2023
entrez: 14 6 2023
Statut: ppublish

Résumé

The resorcinol-terpene phytocannabinoid template is a privileged scaffold for the development of diverse therapeutics targeting the endocannabinoid system. Axially chiral cannabinols (

Identifiants

DOI: 10.1021/jacs.3c00129 PMID: 37314891
pubmed: 37314891
doi: 10.1021/jacs.3c00129
doi:

Substances chimiques

Cannabinoids 0
Endocannabinoids 0
Receptors, Cannabinoid 0
Ligands 0
Cannabidiol 19GBJ60SN5
Cannabinol 7UYP6MC9GH

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Pagination

13581-13591

Subventions

Organisme : NIGMS NIH HHS
ID : R35 GM137893
Pays : United States
Organisme : NCCIH NIH HHS
ID : R01 AT010773
Pays : United States
Organisme : NIDA NIH HHS
ID : K01 DA045752
Pays : United States
Organisme : NIH HHS
ID : S10 OD021758
Pays : United States

Auteurs

Sara E Kearney (SE)

Department of Chemistry, University of Florida, Gainesville, Florida 32611, United States.

Anghelo J Gangano (AJ)

Department of Chemistry, University of Florida, Gainesville, Florida 32611, United States.
ORCID: 0000-0002-5577-5503

Daniel G Barrus (DG)

Analytical Chemistry and Pharmaceutics, RTI International, Research Triangle Park, North Carolina 27709, United States.

Kyle J Rehrauer (KJ)

Concordia University Wisconsin School of Pharmacy, Mequon, Wisconsin 53097, United States.

Terry-Elinor R Reid (TR)

Concordia University Wisconsin School of Pharmacy, Mequon, Wisconsin 53097, United States.

Primali V Navaratne (PV)

Department of Chemistry, University of Florida, Gainesville, Florida 32611, United States.

Emily K Tracy (EK)

Analytical Chemistry and Pharmaceutics, RTI International, Research Triangle Park, North Carolina 27709, United States.

Adrian Roitberg (A)

Department of Chemistry, University of Florida, Gainesville, Florida 32611, United States.
ORCID: 0000-0003-3963-8784

Ion Ghiviriga (I)

Department of Chemistry, University of Florida, Gainesville, Florida 32611, United States.
ORCID: 0000-0001-5812-5170

Christopher W Cunningham (CW)

Concordia University Wisconsin School of Pharmacy, Mequon, Wisconsin 53097, United States.
ORCID: 0000-0002-4468-2213

Thomas Gamage (T)

Analytical Chemistry and Pharmaceutics, RTI International, Research Triangle Park, North Carolina 27709, United States.
ORCID: 0000-0003-3528-9695

Alexander J Grenning (AJ)

Department of Chemistry, University of Florida, Gainesville, Florida 32611, United States.
ORCID: 0000-0002-8182-9464

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Classifications MeSH

questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Terpènes › Cannabinoïdes › Axially Chiral Cannabinoids: Design,...
questionsmedicales.fr › Lipides › Acides gras › Endocannabinoïdes › Axially Chiral Cannabinoids: Design,...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs couplés aux protéines G › Récepteurs de cannabinoïdes › Axially Chiral Cannabinoids: Design,...
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Produits chimiques de laboratoire › Ligands › Axially Chiral Cannabinoids: Design,...
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Terpènes › Cannabinoïdes › Cannabidiol › Axially Chiral Cannabinoids: Design,...
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Terpènes › Cannabinoïdes › Cannabinol › Axially Chiral Cannabinoids: Design,...