Fibronectin-targeted FUD and PEGylated FUD peptides for fibrotic diseases.
Extracellular matrix
Fibronectin
Fibrosis
Functional upstream domain
PEGylation
Journal
Journal of controlled release : official journal of the Controlled Release Society
ISSN: 1873-4995
Titre abrégé: J Control Release
Pays: Netherlands
ID NLM: 8607908
Informations de publication
Date de publication:
08 2023
08 2023
Historique:
received:
25
02
2023
revised:
03
06
2023
accepted:
06
06
2023
pmc-release:
01
08
2024
medline:
21
8
2023
pubmed:
15
6
2023
entrez:
14
6
2023
Statut:
ppublish
Résumé
Tissue fibrosis is characterized by excessive deposition of extracellular matrix (ECM) molecules. Fibronectin (FN) is a glycoprotein found in the blood and tissues, a key player in the assembly of ECM through interaction with cellular and extracellular components. Functional Upstream Domain (FUD), a peptide derived from an adhesin protein of bacteria, has a high binding affinity for the N-terminal 70-kDa domain of FN that plays a crucial role in FN polymerization. In this regard, FUD peptide has been characterized as a potent inhibitor of FN matrix assembly, reducing excessive ECM accumulation. Furthermore, PEGylated FUD was developed to prevent rapid elimination of FUD and enhance its systemic exposure in vivo. Herein, we summarize the development of FUD peptide as a potential anti-fibrotic agent and its application in experimental fibrotic diseases. In addition, we discuss how modification of the FUD peptide via PEGylation impacts pharmacokinetic profiles of the FUD peptide and can potentially contribute to anti-fibrosis therapy.
Identifiants
pubmed: 37315694
pii: S0168-3659(23)00378-4
doi: 10.1016/j.jconrel.2023.06.008
pmc: PMC10527082
mid: NIHMS1908484
pii:
doi:
Substances chimiques
Adhesins, Bacterial
0
Fibronectins
0
Peptides
0
Polyethylene Glycols
3WJQ0SDW1A
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
69-81Subventions
Organisme : NCI NIH HHS
ID : R01 CA257837
Pays : United States
Organisme : NCI NIH HHS
ID : R21 CA252579
Pays : United States
Informations de copyright
Copyright © 2023 Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest None.
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