T cell immunity in interstitial lung disease with non-small cell lung cancer patients.

Humans Carcinoma, Non-Small-Cell Lung / therapy Lung Neoplasms / therapy CD8-Positive T-Lymphocytes Tumor Necrosis Factor-alpha Lung Diseases, Interstitial Pneumonia Retrospective Studies
Interstitial lung disease Non-small cell lung cancer Tumor necrosis factor-α regulatory T cells

Journal

Lung cancer (Amsterdam, Netherlands)
ISSN: 1872-8332
Titre abrégé: Lung Cancer
Pays: Ireland
ID NLM: 8800805

Informations de publication

Date de publication:
08 2023
Historique:
received: 07 02 2023
revised: 01 05 2023
accepted: 06 06 2023
medline: 24 7 2023
pubmed: 16 6 2023
entrez: 15 6 2023
Statut: ppublish

Résumé

Limited treatment options are available for non-small cell lung cancer (NSCLC) patients with interstitial lung disease (ILD). The rationale for immunotherapy and its adverse events for NSCLC with ILD remains unclear. In this study, we examined T cell profiles and functions in the lung tissues of NSCLC patients with or without ILD to provide evidence for the potential mechanism of immune checkpoint inhibitor (ICI)-related pneumonitis in NSCLC patients with ILD. We investigated T cell immunity in the lung tissues of NSCLC patients with ILD to support the application of immunotherapy for these patients. We analyzed T cell profiles and functions in surgically resected lung tissues from NSCLC patients with and without ILD. The T cell profiles of infiltrating cells in lung tissues were analyzed by flow cytometry. T cell functions were measured based on cytokine production by T cells stimulated with phorbol 12-myristate 13-acetate and ionomycin. The percentages of CD4 In NSCLC patients with ILD stable for surgery, T cells were active participants and balanced in part by Treg cells in lung tissues, suggesting the potential development of ICI-related pneumonitis in NSCLC patients with ILD.

Identifiants

DOI: 10.1016/j.lungcan.2023.107278 PMID: 37321075
pubmed: 37321075
pii: S0169-5002(23)00816-4
doi: 10.1016/j.lungcan.2023.107278
pii:
doi:

Substances chimiques

Tumor Necrosis Factor-alpha 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

107278

Informations de copyright

Copyright © 2023 Elsevier B.V. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Auteurs

Tomomi Isono (T)

Department of Thoracic Surgery, Graduate School of Medicine, Osaka University, Osaka, Japan.

Kota Iwahori (K)

Department of Clinical Research in Tumor Immunology, Graduate School of Medicine, Osaka University, Osaka, Japan; Department of Respiratory Medicine and Clinical Immunology, Graduate School of Medicine, Osaka University, Osaka, Japan. Electronic address: iwahori@climm.med.osaka-u.ac.jp.

Masahiro Yanagawa (M)

Department of Radiology, Graduate School of Medicine, Osaka University, Osaka, Japan.

Yoko Yamamoto (Y)

Department of Thoracic Surgery, Graduate School of Medicine, Osaka University, Osaka, Japan.

Mari Tone (M)

Department of Respiratory Medicine and Clinical Immunology, Graduate School of Medicine, Osaka University, Osaka, Japan.

Miya Haruna (M)

Department of Clinical Research in Tumor Immunology, Graduate School of Medicine, Osaka University, Osaka, Japan; Biopharmaceutical Research Division, Shionogi & Co., Ltd., Osaka, Japan.

Michinari Hirata (M)

Department of Clinical Research in Tumor Immunology, Graduate School of Medicine, Osaka University, Osaka, Japan; Biopharmaceutical Research Division, Shionogi & Co., Ltd., Osaka, Japan.

Eriko Fukui (E)

Department of Thoracic Surgery, Graduate School of Medicine, Osaka University, Osaka, Japan.

Toru Kimura (T)

Department of Thoracic Surgery, Graduate School of Medicine, Osaka University, Osaka, Japan.

Takashi Kanou (T)

Department of Thoracic Surgery, Graduate School of Medicine, Osaka University, Osaka, Japan.

Naoko Ose (N)

Department of Thoracic Surgery, Graduate School of Medicine, Osaka University, Osaka, Japan.

Soichiro Funaki (S)

Department of Thoracic Surgery, Graduate School of Medicine, Osaka University, Osaka, Japan.

Yoshito Takeda (Y)

Department of Respiratory Medicine and Clinical Immunology, Graduate School of Medicine, Osaka University, Osaka, Japan.

Eiichi Morii (E)

Department of Pathology, Graduate School of Medicine, Osaka University, Osaka, Japan.

Atsushi Kumanogoh (A)

Department of Respiratory Medicine and Clinical Immunology, Graduate School of Medicine, Osaka University, Osaka, Japan; Department of Immunopathology, World Premier International Research Center Initiative (WPI), Immunology Frontier Research Center (IFReC), Osaka University, Osaka, Japan; Integrated Frontier Research for Medical Science Division, Institute for Open and Transdisciplinary Research Initiatives (OTRI), Osaka University, Osaka, Japan; Center for Infectious Diseases for Education and Research (CiDER), Osaka University, Osaka, Japan; Japan Agency for Medical Research and Development - Core Research for Evolutional Science and Technology (AMED-CREST), Osaka University, Osaka, Japan; Center for Advanced Modalities and DDS (CAMaD), Osaka University, Osaka, Japan.

Yasushi Shintani (Y)

Department of Thoracic Surgery, Graduate School of Medicine, Osaka University, Osaka, Japan.

Hisashi Wada (H)

Department of Clinical Research in Tumor Immunology, Graduate School of Medicine, Osaka University, Osaka, Japan.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › T cell immunity in interstitial lung disease...
questionsmedicales.fr › Maladies de l'appareil respiratoire › Tumeurs de l'appareil respiratoire › Tumeurs du poumon › Tumeurs des bronches › Carcinome bronchogénique › Carcinome pulmonaire non à petites cellules › T cell immunity in interstitial lung disease...
questionsmedicales.fr › Maladies de l'appareil respiratoire › Tumeurs de l'appareil respiratoire › Tumeurs du poumon › T cell immunity in interstitial lung disease...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Lymphocytes T CD8+ › T cell immunity in interstitial lung disease...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Facteurs de nécrose tumorale › Facteur de nécrose tumorale alpha › T cell immunity in interstitial lung disease...
questionsmedicales.fr › Maladies de l'appareil respiratoire › Maladies pulmonaires › Pneumopathies interstitielles › T cell immunity in interstitial lung disease...
questionsmedicales.fr › Maladies de l'appareil respiratoire › Infections de l'appareil respiratoire › Pneumopathie infectieuse › T cell immunity in interstitial lung disease...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Études rétrospectives › T cell immunity in interstitial lung disease...