Impact of genetic variants within serotonin turnover enzymes on human cerebral monoamine oxidase A in vivo.

Humans Brain / diagnostic imaging Harmine / metabolism Monoamine Oxidase / genetics Seasonal Affective Disorder / metabolism Serotonin / metabolism

Journal

Translational psychiatry
ISSN: 2158-3188
Titre abrégé: Transl Psychiatry
Pays: United States
ID NLM: 101562664

Informations de publication

Date de publication:
15 Jun 2023
Historique:
received: 21 11 2022
accepted: 01 06 2023
revised: 28 05 2023
medline: 19 6 2023
pubmed: 16 6 2023
entrez: 15 6 2023
Statut: epublish

Résumé

Variants within the monoamine oxidase A (MAO-A, MAOA) and tryptophan hydroxylase 2 (TPH2) genes, the main enzymes in cerebral serotonin (5-HT) turnover, affect risk for depression. Depressed cohorts show increased cerebral MAO-A in positron emission tomography (PET) studies. TPH2 polymorphisms might also influence brain MAO-A because availability of substrates (i.e. monoamine concentrations) were shown to affect MAO-A levels. We assessed the effect of MAOA (rs1137070, rs2064070, rs6323) and TPH2 (rs1386494, rs4570625) variants associated with risk for depression and related clinical phenomena on global MAO-A distribution volume (V

Identifiants

DOI: 10.1038/s41398-023-02506-2 PMID: 37322010 PMC: PMC10272199
pubmed: 37322010
doi: 10.1038/s41398-023-02506-2
pii: 10.1038/s41398-023-02506-2
pmc: PMC10272199
doi:

Substances chimiques

Harmine 4FHH5G48T7
Monoamine Oxidase EC 1.4.3.4
Serotonin 333DO1RDJY
monoamine oxidase A, human EC 1.4.3.4.

Banques de données

ClinicalTrials.gov
['NCT02582398']

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

208

Subventions

Organisme : Austrian Science Fund FWF
ID : DOC 33
Pays : Austria

Informations de copyright

© 2023. The Author(s).

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Auteurs

Marie Spies (M)

Department of Psychiatry and Psychotherapy, Comprehensive Center for Clinical Neurosciences and Mental Health (C3NMH), Medical University of Vienna, Vienna, Austria.

Matej Murgaš (M)

Department of Psychiatry and Psychotherapy, Comprehensive Center for Clinical Neurosciences and Mental Health (C3NMH), Medical University of Vienna, Vienna, Austria.
ORCID: 0000-0001-7643-2182

Chrysoula Vraka (C)

Department of Biomedical Imaging and Image-guided Therapy, Division of Nuclear Medicine, Medical University of Vienna, Vienna, Austria.

Cecile Philippe (C)

Department of Biomedical Imaging and Image-guided Therapy, Division of Nuclear Medicine, Medical University of Vienna, Vienna, Austria.

Gregor Gryglewski (G)

Department of Psychiatry and Psychotherapy, Comprehensive Center for Clinical Neurosciences and Mental Health (C3NMH), Medical University of Vienna, Vienna, Austria.
Child Study Center, Yale University, New Haven, CT, USA.
ORCID: 0000-0002-7344-8071

Lukas Nics (L)

Department of Biomedical Imaging and Image-guided Therapy, Division of Nuclear Medicine, Medical University of Vienna, Vienna, Austria.

Theresa Balber (T)

Department of Biomedical Imaging and Image-guided Therapy, Division of Nuclear Medicine, Medical University of Vienna, Vienna, Austria.
Ludwig Boltzmann Institute Applied Diagnostics, Vienna, Austria.

Pia Baldinger-Melich (P)

Department of Psychiatry and Psychotherapy, Comprehensive Center for Clinical Neurosciences and Mental Health (C3NMH), Medical University of Vienna, Vienna, Austria.
ORCID: 0000-0001-8382-6665

Annette M Hartmann (AM)

Department of Psychiatry and Psychotherapy, Comprehensive Center for Clinical Neurosciences and Mental Health (C3NMH), Medical University of Vienna, Vienna, Austria.

Dan Rujescu (D)

Department of Psychiatry and Psychotherapy, Comprehensive Center for Clinical Neurosciences and Mental Health (C3NMH), Medical University of Vienna, Vienna, Austria.
ORCID: 0000-0002-1432-313X

Marcus Hacker (M)

Department of Biomedical Imaging and Image-guided Therapy, Division of Nuclear Medicine, Medical University of Vienna, Vienna, Austria.

Edda Winkler-Pjrek (E)

Department of Psychiatry and Psychotherapy, Comprehensive Center for Clinical Neurosciences and Mental Health (C3NMH), Medical University of Vienna, Vienna, Austria.

Dietmar Winkler (D)

Department of Psychiatry and Psychotherapy, Comprehensive Center for Clinical Neurosciences and Mental Health (C3NMH), Medical University of Vienna, Vienna, Austria.
ORCID: 0000-0001-8849-9907

Rupert Lanzenberger (R)

Department of Psychiatry and Psychotherapy, Comprehensive Center for Clinical Neurosciences and Mental Health (C3NMH), Medical University of Vienna, Vienna, Austria. rupert.lanzenberger@meduniwien.ac.at.
ORCID: 0000-0003-4641-9539

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Impact of genetic variants within serotonin...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Impact of genetic variants within serotonin...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérocycliques 3 noyaux › Carbolines › Harmine › Impact of genetic variants within serotonin...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Oxidoreductases › Oxidoreductases acting on CH-NH2 group donors › Monoamine oxidase › Impact of genetic variants within serotonin...
questionsmedicales.fr › Troubles mentaux › Troubles de l'humeur › Trouble dépressif › Trouble affectif saisonnier › Impact of genetic variants within serotonin...
questionsmedicales.fr › Facteurs biologiques › Médiateurs de l'inflammation › Autacoïdes › Sérotonine › Impact of genetic variants within serotonin...