Syndrome of inappropriate secretion of anti-diuretic hormone due to hypothalamic hamartoma: use of tolvaptan.
hypothalamic hamartoma
syndrome of inappropriate secretion of antidiuretic hormone (SIADH)
tolvaptan
Journal
Journal of pediatric endocrinology & metabolism : JPEM
ISSN: 2191-0251
Titre abrégé: J Pediatr Endocrinol Metab
Pays: Germany
ID NLM: 9508900
Informations de publication
Date de publication:
26 Sep 2023
26 Sep 2023
Historique:
received:
27
03
2023
accepted:
05
06
2023
medline:
6
9
2023
pubmed:
16
6
2023
entrez:
16
6
2023
Statut:
epublish
Résumé
Hypothalamic hamartoma (HH) typically presents with gonadotrophin-dependent precocious puberty and/or seizures. Other endocrine disturbances are rare. We describe an infant with syndrome of inappropriate secretion of anti-diuretic hormone (SIADH) and a HH. A 6-week-old infant presented with seizures and life-threatening hyponatremia. A HH was identified on magnetic resonance imaging. Clinical examination and biochemistry were consistent with SIADH, and serum copeptin was high during hyponatremia, further supporting this diagnosis. Tolvaptan was effective in normalizing plasma sodium and enabling liberalization of fluids to ensure sufficient nutritional intake and weight gain and manage hunger. Hyponatremia due to SIADH is novel at presentation of a HH, and can be challenging to diagnose and manage. Successful management of hyponatremia in this case was achieved using tolvaptan.
Identifiants
pubmed: 37327191
pii: jpem-2023-0136
doi: 10.1515/jpem-2023-0136
doi:
Substances chimiques
Tolvaptan
21G72T1950
Antidiuretic Hormone Receptor Antagonists
0
Diuretics
0
Benzazepines
0
Vasopressins
11000-17-2
Types de publication
Case Reports
Langues
eng
Sous-ensembles de citation
IM
Pagination
895-899Informations de copyright
© 2023 Walter de Gruyter GmbH, Berlin/Boston.
Références
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