Efficacy of ultraviolet B radiation versus vitamin D
Cognitive dysfunction
Postural control
Relapsing-remitting multiple sclerosis
Ultraviolet radiation
Vitamin D(3)
Journal
Journal of bodywork and movement therapies
ISSN: 1532-9283
Titre abrégé: J Bodyw Mov Ther
Pays: United States
ID NLM: 9700068
Informations de publication
Date de publication:
07 2023
07 2023
Historique:
received:
12
09
2021
revised:
20
03
2023
accepted:
15
04
2023
medline:
19
6
2023
pubmed:
18
6
2023
entrez:
18
6
2023
Statut:
ppublish
Résumé
The relapsing-remitting multiple sclerosis (RRMS) is the most common type of MS with prevalence rate 20-60 patients/100.000 individuals in Egypt. Poor postural control and cognitive dysfunctions are well-established complications of RRMS without potent remedy yet. The latest evidence highlighted the potential and independent immune-modulating effects of vitamin D To investigate the efficacy of broadband ultraviolet B radiation (UVBR) versus moderate loading dose of vitamin D Pretest-posttest randomized controlled study. Multiple sclerosis outpatient unit of Kasr Al-Ainy Hospital. Forty-seven patients with RRMS were recruited from both genders, yet only 40 completed the study. Patients were randomized into two groups: UVBR group involved 24 patients, received sessions for 4 weeks and vitamin D Overall balance system index (OSI) and symbol digit modalities test (SDMT). Highly significant decrease (P < 0.001) of the OSI in both groups post-treatment, indicating improved postural control. Moreover, highly significant improvement in the SDMT scores was noted, indicating information processing speed enhancement. Nonetheless, no statistically significant (P ≥ 0.05) differences were evident between the two groups post-treatment in all tested measures. Both therapeutic programs were statistically equal in improving postural control and cognitive functions. However, clinically, UVBR therapy was more convenient owing to its shorter treatment time and higher percentage of change for all tested measures.
Sections du résumé
BACKGROUND
The relapsing-remitting multiple sclerosis (RRMS) is the most common type of MS with prevalence rate 20-60 patients/100.000 individuals in Egypt. Poor postural control and cognitive dysfunctions are well-established complications of RRMS without potent remedy yet. The latest evidence highlighted the potential and independent immune-modulating effects of vitamin D
OBJECTIVE
To investigate the efficacy of broadband ultraviolet B radiation (UVBR) versus moderate loading dose of vitamin D
DESIGN
Pretest-posttest randomized controlled study.
SETTING
Multiple sclerosis outpatient unit of Kasr Al-Ainy Hospital.
PARTICIPANTS
Forty-seven patients with RRMS were recruited from both genders, yet only 40 completed the study.
INTERVENTIONS
Patients were randomized into two groups: UVBR group involved 24 patients, received sessions for 4 weeks and vitamin D
MAIN OUTCOME MEASURES
Overall balance system index (OSI) and symbol digit modalities test (SDMT).
RESULTS
Highly significant decrease (P < 0.001) of the OSI in both groups post-treatment, indicating improved postural control. Moreover, highly significant improvement in the SDMT scores was noted, indicating information processing speed enhancement. Nonetheless, no statistically significant (P ≥ 0.05) differences were evident between the two groups post-treatment in all tested measures.
CONCLUSION
Both therapeutic programs were statistically equal in improving postural control and cognitive functions. However, clinically, UVBR therapy was more convenient owing to its shorter treatment time and higher percentage of change for all tested measures.
Identifiants
pubmed: 37330802
pii: S1360-8592(23)00084-0
doi: 10.1016/j.jbmt.2023.04.069
pii:
doi:
Substances chimiques
Cholecalciferol
1C6V77QF41
Types de publication
Randomized Controlled Trial
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
49-56Informations de copyright
Copyright © 2023 Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest Authors declare no conflict of interest.