Treatment Approaches to Granulomatosis with Polyangiitis and Microscopic Polyangiitis.

Humans Microscopic Polyangiitis / drug therapy Granulomatosis with Polyangiitis / drug therapy Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis / drug therapy Remission Induction Rituximab / therapeutic use Antibodies, Antineutrophil Cytoplasmic
ANCA vasculitis Granulomatosis with polyangiitis Microscopic polyangiitis Treatment

Journal

Rheumatic diseases clinics of North America
ISSN: 1558-3163
Titre abrégé: Rheum Dis Clin North Am
Pays: United States
ID NLM: 8708093

Informations de publication

Date de publication:
08 2023
Historique:
medline: 20 6 2023
pubmed: 19 6 2023
entrez: 18 6 2023
Statut: ppublish

Résumé

We have made significant headway in our ability to induce and maintain remission in patients with granulomatosis with polyangiitis and microscopic polyangiitis. With increased understanding of the pathogenesis of antineutrophilic cytoplasmic antibody-associated vasculitides (AAV), therapeutic targets have been identified and studied in clinical trials. From initial induction strategies including glucocorticoids and cyclophosphamide, we have discovered effective induction regimens with rituximab and complement inhibition that can significantly decrease the glucocorticoid cumulative doses in patients with AAV. There are many trials underway evaluating management strategies for refractory patients and exploring new and old therapies that may help to continuously improve outcomes for patients with AAV.

Identifiants

DOI: 10.1016/j.rdc.2023.03.004 PMID: 37331732
pubmed: 37331732
pii: S0889-857X(23)00035-2
doi: 10.1016/j.rdc.2023.03.004
pii:
doi:

Substances chimiques

Rituximab 4F4X42SYQ6
Antibodies, Antineutrophil Cytoplasmic 0

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

545-561

Informations de copyright

Copyright © 2023 Elsevier Inc. All rights reserved.

Auteurs

Alvise Berti (A)

Center for Medical Sciences (CISMed), Department of Cellular, Computational and Integrative Biology (CIBIO), University of Trento, and Division of Rheumatology, Santa Chiara Hospital, APSS Trento, Italy.

Divi Cornec (D)

Rheumatology Department, INSERM UMR1227 LBAI, Lymphocytes B, Autoimmunité et Immunothérapies, University of Brest, National Reference Center for Rare Systemic Autoimmune Diseases CERAINO, CHRU Brest, Brest, France. Electronic address: divi.cornec@chu-brest.fr.

Anisha B Dua (AB)

Division of Rheumatology, Northwestern University Feinberg School of Medicine, 675 North Saint Clair Street, Suite 14-100, Chicago, IL 60611, USA.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Treatment Approaches to Granulomatosis with...
questionsmedicales.fr › Maladies du système immunitaire › Maladies auto-immunes › Vascularites associées aux anticorps anti-cytoplasme des neutrophiles › Polyangéite microscopique › Treatment Approaches to Granulomatosis with...
questionsmedicales.fr › Maladies du système immunitaire › Maladies auto-immunes › Vascularites associées aux anticorps anti-cytoplasme des neutrophiles › Granulomatose avec polyangéite › Treatment Approaches to Granulomatosis with...
questionsmedicales.fr › Maladies du système immunitaire › Maladies auto-immunes › Vascularites associées aux anticorps anti-cytoplasme des neutrophiles › Treatment Approaches to Granulomatosis with...
questionsmedicales.fr › Thérapeutique › Induction de rémission › Treatment Approaches to Granulomatosis with...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Globulines › Sérum-globulines › Immunoglobulines › Anticorps › Anticorps monoclonaux › Anticorps monoclonaux d'origine murine › Rituximab › Treatment Approaches to Granulomatosis with...
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Anticorps anti-cytoplasme des polynucléaires neutrophiles › Treatment Approaches to Granulomatosis with...