The molecular basis of the neutralization breadth of the RBD-specific antibody CoV11.
SARS-CoV-2
VH 3-53 germline gene (IGHV3-53*01)
neutralizing antibody
receptor binding domain (RBD)
variants of concern (VOC)
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2023
2023
Historique:
received:
02
03
2023
accepted:
16
05
2023
medline:
20
6
2023
pubmed:
19
6
2023
entrez:
19
6
2023
Statut:
epublish
Résumé
SARS-CoV-2, the virus behind the COVID-19 pandemic, has changed over time to the extent that the current virus is substantially different from what originally led to the pandemic in 2019-2020. Viral variants have modified the severity and transmissibility of the disease and continue do so. How much of this change is due to viral fitness versus a response to immune pressure is hard to define. One class of antibodies that continues to afford some level of protection from emerging variants are those that closely overlap the binding site for angiotensin-converting enzyme 2 (ACE2) on the receptor binding domain (RBD). Some members of this class that were identified early in the course of the pandemic arose from the V
Identifiants
pubmed: 37334379
doi: 10.3389/fimmu.2023.1178355
pmc: PMC10272436
doi:
Substances chimiques
Antibodies
0
Blood Group Antigens
0
Types de publication
Journal Article
Research Support, N.I.H., Intramural
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1178355Subventions
Organisme : BLRD VA
ID : I01 BX005469
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI147870
Pays : United States
Informations de copyright
Copyright © 2023 Tolbert, Chen, Sun, Benlarbi, Ding, Manickam, Pangaro, Nguyen, Gottumukkala, Côté, Gonzalez, Finzi, Tehrani, Sajadi and Pazgier.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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