Polymer Nanoantidotes.
biomimetic clearance
chemical bonding
clinical practice
physical interaction
polymer nanoantidote
Journal
Chemistry (Weinheim an der Bergstrasse, Germany)
ISSN: 1521-3765
Titre abrégé: Chemistry
Pays: Germany
ID NLM: 9513783
Informations de publication
Date de publication:
26 Jul 2023
26 Jul 2023
Historique:
received:
06
04
2023
medline:
27
7
2023
pubmed:
19
6
2023
entrez:
19
6
2023
Statut:
ppublish
Résumé
Intoxication is one of the most common causes of accidental death globally. Although some antidotes capable of neutralizing the toxicity of certain xenobiotics have become well established, the current reality is that clinicians primarily rely on nonspecific extracorporeal techniques to remove toxins. Nano-intervention strategies in which nanoantidotes neutralize toxicity in situ via physical interaction, chemical bonding, or biomimetic clearance have begun to show clinical potential. However, most nanoantidotes remain in the proof-of-concept stage, and the difficulty of constructing clinical relevance models and the unclear pharmacokinetics of nanoantidotes hinder their translation to clinic. This Concept reviews the detoxification mechanisms of polymer nanoantidotes and predicts the opportunities and challenges associated with their clinical application.
Identifiants
pubmed: 37335074
doi: 10.1002/chem.202301107
doi:
Substances chimiques
Polymers
0
Antidotes
0
Toxins, Biological
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e202301107Subventions
Organisme : National Natural Science Foundation of China
ID : Nos. 52273158
Organisme : National Natural Science Foundation of China
ID : Nos.52022095
Organisme : Science and Technology Development Program of Jilin Province
ID : No. 20210509005RQ
Organisme : Youth Innovation Promotion Association of Chinese Academy of Sciences
ID : No. 2019230
Informations de copyright
© 2023 Wiley-VCH GmbH.
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