Sleep-promoting activity of amylase-treated Ashwagandha (Withania somnifera L. Dunal) root extract via GABA receptors.

Receptors, GABA Withania / chemistry Sleep Initiation and Maintenance Disorders Pentobarbital / pharmacology Amylases / pharmacology Plant Extracts / pharmacology Sleep gamma-Aminobutyric Acid

Journal

Journal of food and drug analysis
ISSN: 2224-6614
Titre abrégé: J Food Drug Anal
Pays: China (Republic : 1949- )
ID NLM: 101630927

Informations de publication

Date de publication:
15 06 2023
Historique:
received: 02 11 2022
accepted: 16 03 2023
medline: 21 6 2023
pubmed: 19 6 2023
entrez: 19 6 2023
Statut: epublish

Résumé

Ashwagandha (Withania somnifera L. Dunal), an Indian medicinal plant that has been used for centuries to treat insomnia, exhibits a variety of biological activities, such as improving cognitive function, immunity and anxiety. In this study, the effect of enzyme-treated Ashwagandha root extract (EA) and on sleep was evaluated using rodent models. Starch contained in the Ashwagandha root extract was removed by amylase treatment to prepare EA. To evaluate the sleep-promoting activity of EA, a pentobarbital-induced sleep test and electroencephalogram analysis were performed. In addition, the sleep-promoting mechanism of EA was elucidated by analyzing the expression of sleep-related receptors. In the pentobarbital-induced sleep test, EA dose-dependently increased sleep duration. Additionally, electroencephalogram analysis revealed that EA significantly increased δ-wave and non-rapid eye movement sleep times, which are involved in deep sleep, thereby improving sleep quality and quantity. EA also effectively relieved caffeine-induced insomnia symptoms. Furthermore, the γ-aminobutyric acid (GABA) content in the brain and mRNA and protein expression of GABA

Identifiants

DOI: 10.38212/2224-6614.3456 PMID: 37335157 PMC: PMC10281725
pubmed: 37335157
pii: 2224-6614.3456
doi: 10.38212/2224-6614.3456
pmc: PMC10281725
doi:

Substances chimiques

Ashwagandha V038D626IF
Receptors, GABA 0
Pentobarbital I4744080IR
Amylases EC 3.2.1.-
Plant Extracts 0
gamma-Aminobutyric Acid 56-12-2

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

278-288

Références

BMC Complement Altern Med. 2011 Sep 22;11:78
pubmed: 21939549
Rev Neurosci. 1998;9(4):265-73
pubmed: 9886141
PLoS One. 2017 Feb 16;12(2):e0172508
pubmed: 28207892
J Ethnopharmacol. 2021 Mar 1;267:113511
pubmed: 33148434
Annu Rev Neurosci. 1994;17:569-602
pubmed: 7516126
Sleep Med Rev. 2015 Dec;24:1-12
pubmed: 25644982
Pharm Biol. 2022 Dec;60(1):1341-1348
pubmed: 35840545
Indian J Exp Biol. 2007 Jun;45(6):524-8
pubmed: 17585686
J Evid Based Integr Med. 2020 Jan-Dec;25:2515690X20967323
pubmed: 33086877
Nat Rev Neurosci. 2005 Mar;6(3):215-29
pubmed: 15738957
PLoS One. 2021 Sep 24;16(9):e0257843
pubmed: 34559859
Int J Mol Sci. 2009 May 20;10(5):2367-2382
pubmed: 19564954
J Ethnopharmacol. 2020 Jul 15;257:112876
pubmed: 32305638
J Exp Biol. 2013 Oct 15;216(Pt 20):3837-43
pubmed: 24068350
Int J Mol Sci. 2021 Mar 29;22(7):
pubmed: 33805468
Neuroscience. 2002;111(2):231-9
pubmed: 11983310
Behav Brain Res. 2007 Jun 4;180(1):62-8
pubmed: 17399804
Nutrients. 2020 May 25;12(5):
pubmed: 32466115
Age (Dordr). 2013 Aug;35(4):1277-85
pubmed: 22622709
Sleep Med Rev. 2002 Apr;6(2):97-111
pubmed: 12531146
J Psychopharmacol. 2021 Oct;35(10):1277-1284
pubmed: 33934670
Brain Res Brain Res Rev. 1992 May-Aug;17(2):139-70
pubmed: 1356551
Prog Neuropsychopharmacol Biol Psychiatry. 2008 Jul 1;32(5):1093-105
pubmed: 17959291
Curr Neuropharmacol. 2021;19(9):1468-1495
pubmed: 34254920
Behav Brain Res. 2000 Sep;114(1-2):31-8
pubmed: 10996044
Molecules. 2021 Nov 24;26(23):
pubmed: 34885687
J Ethnopharmacol. 2012 Jan 6;139(1):164-70
pubmed: 22101086
Curr Neuropharmacol. 2014 May;12(3):289-302
pubmed: 24851093
Lancet Reg Health Am. 2022 Jan 24;10:100190
pubmed: 36777690
J Ethnopharmacol. 2015 Aug 2;171:264-72
pubmed: 26068424
Evid Based Complement Alternat Med. 2017;2017:3019568
pubmed: 28680447
J Med Chem. 1994 Aug 5;37(16):2489-505
pubmed: 8057295
Sleep Med Rev. 2022 Aug;64:101657
pubmed: 35753151
J Ayurveda Integr Med. 2014 Oct-Dec;5(4):216-22
pubmed: 25624695
Phytother Res. 2010 Aug;24(8):1147-50
pubmed: 20044800
J Agric Food Chem. 2020 Mar 11;68(10):3149-3162
pubmed: 32062961
J Ethnopharmacol. 2021 Jan 10;264:113276
pubmed: 32818573
J Ethnopharmacol. 2012 Aug 30;143(1):213-20
pubmed: 22750453
J Ethnopharmacol. 2009 Sep 25;125(3):369-73
pubmed: 19666100
Exp Gerontol. 2016 Jun;78:47-56
pubmed: 26956478
J Diet Suppl. 2017 Nov 2;14(6):599-612
pubmed: 28471731

Auteurs

Chun Woong Park (CW)

BK21FOUR R&E Center for Learning Health Systems, Korea University, Seoul 02841, South Korea.
Department of Integrated Biomedical and Life Science, Graduate School, Korea University, Seoul 02841, South Korea.

Ki-Bae Hong (KB)

Department of Food Science and Nutrition, Jeju National University, Jeju 63243, South Korea.

Hyung Joo Suh (HJ)

BK21FOUR R&E Center for Learning Health Systems, Korea University, Seoul 02841, South Korea.
Department of Integrated Biomedical and Life Science, Graduate School, Korea University, Seoul 02841, South Korea.

Yejin Ahn (Y)

Department of Integrated Biomedical and Life Science, Graduate School, Korea University, Seoul 02841, South Korea.

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs aux neuromédiateurs › Récepteurs aux acides aminés › Récepteurs GABA › Sleep-promoting activity of amylase-treated...
questionsmedicales.fr › Eucaryotes › Viridiplantae › Streptophyta › Embryophyta › Tracheobionta › Magnoliopsida › Solanales › Solanaceae › Withania › Sleep-promoting activity of amylase-treated...
questionsmedicales.fr › Troubles mentaux › Troubles de la veille et du sommeil › Dyssomnies › Troubles du sommeil d'origine intrinsèque › Troubles de l'endormissement et du maintien du sommeil › Sleep-promoting activity of amylase-treated...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Pyrimidines › Pyrimidinones › Barbituriques › Pentobarbital › Sleep-promoting activity of amylase-treated...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Glycosidases › Amylases › Sleep-promoting activity of amylase-treated...
questionsmedicales.fr › Préparations pharmaceutiques › Extraits de plantes › Sleep-promoting activity of amylase-treated...
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système nerveux › Sommeil › Sleep-promoting activity of amylase-treated...
questionsmedicales.fr › Acides aminés, peptides et protéines › Acides aminés › Amino-butyrates › Acide gamma-amino-butyrique › Sleep-promoting activity of amylase-treated...