Diosgenin Attenuates Myocardial Cell Apoptosis Triggered by Oxidative Stress through Estrogen Receptor to Activate the PI3K/Akt and ERK Axes.

Infant, Newborn Female Humans Proto-Oncogene Proteins c-akt / metabolism Receptors, Estrogen / metabolism Phosphatidylinositol 3-Kinases / metabolism Hydrogen Peroxide / toxicity Diosgenin / pharmacology Cardiovascular Diseases Oxidative Stress Apoptosis Estrogens / metabolism Myocytes, Cardiac / metabolism
Apoptosis Chinese Yam Tubers Dioscorea polystachya Diosgenin Menopause Oxidative Stress

Journal

The American journal of Chinese medicine
ISSN: 1793-6853
Titre abrégé: Am J Chin Med
Pays: Singapore
ID NLM: 7901431

Informations de publication

Date de publication:
2023
Historique:
medline: 25 7 2023
pubmed: 19 6 2023
entrez: 19 6 2023
Statut: ppublish

Résumé

Cardiovascular diseases in post-menopausal women are on a rise. Oxidative stress is the main contributing factor to the etiology and pathogenesis of cardiovascular diseases. Diosgenin, a member of steroidal sapogenin, is structurally similar to estrogen and has been shown to have antioxidant effects. Therefore, we aimed to investigate the effects of diosgenin in preventing oxidation-induced cardiomyocyte apoptosis and assessed its potential as a substitute substance for estrogen in post-menopausal women. Apoptotic pathways and mitochondrial membrane potential were measured in H9c2 cardiomyoblast cells and neonatal cardiomyocytes treated with diosgenin for 1[Formula: see text]h prior to hydrogen peroxide (H

Identifiants

DOI: 10.1142/S0192415X23500556 PMID: 37335210
pubmed: 37335210
doi: 10.1142/S0192415X23500556
doi:

Substances chimiques

Proto-Oncogene Proteins c-akt EC 2.7.11.1
Receptors, Estrogen 0
Phosphatidylinositol 3-Kinases EC 2.7.1.-
Hydrogen Peroxide BBX060AN9V
Diosgenin K49P2K8WLX
Estrogens 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

1211-1232

Auteurs

Michael Yu-Chih Chen (MY)

Department of Cardiology, Buddhist Tzu Chi General Hospital, Hualien 970, Taiwan.
School of Medicine, Tzu Chi University, Hualien 970, Taiwan.

Bruce Chi-Kang Tsai (BC)

Cardiovascular and Mitochondrial Related Disease Research Center, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien 970, Taiwan.

Wei-Wen Kuo (WW)

Department of Biological Science and Technology, China Medical University, Taichung 404, Taiwan.
Ph.D. Program for Biotechnology Industry, China Medical University, Taichung 404, Taiwan.

Chia-Hua Kuo (CH)

Laboratory of Exercise Biochemistry, University of Taipei, Taipei 111, Taiwan.

Yueh-Min Lin (YM)

Department of Medical Technology, Jen-Teh Junior College of Medicine, Nursing and Management, Miaoli 356, Taiwan.
Department of Pathology, Changhua Christian Hospital, Changhua 500, Taiwan.

Dennis Jine-Yuan Hsieh (DJ)

School of Medical Laboratory and Biotechnology, Chung Shan Medical University, Taichung 402, Taiwan.
Clinical Laboratory, Chung Shan Medical University Hospital, 402 Taichung, Taiwan.

Pei-Ying Pai (PY)

School of Medicine, College of Medicine, China Medical University, Taichung 404, Taiwan.
Division of Cardiovascular Medicine, Department of Medicine, China Medical University Hospital, Taichung 404, Taiwan.

Shih-Chieh Liao (SC)

Department of Social Medicine, School of Medicine, China Medical University, Taichung 404, Taiwan.

Shang-En Huang (SE)

Graduate Institute of Chinese Medical Science, China Medical University, Taichung 404, Taiwan.

Shin-Da Lee (SD)

Department of Physical Therapy, Graduate Institute of Rehabilitation Science, China Medical University, Taichung 404, Taiwan.
School of Rehabilitation Science, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, P. R. China.
School of Rehabilitation Medicine, Weifang Medical University, Shandong 261053, P. R. China.
Department of Physical Therapy, Asia University, Taichung 413, Taiwan.

Chih-Yang Huang (CY)

Cardiovascular and Mitochondrial Related Disease Research Center, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien 970, Taiwan.
Graduate Institute of Medical Science, China Medical University, Taichung 404, Taiwan.
Department of Medical Research, China Medical University Hospital, China Medical University, Taichung 404, Taiwan.
Department of Medical Laboratory Science and Biotechnology, Asia University, Taichung 413, Taiwan.
Center of General Education, Buddhist Tzu Chi Medical Foundation, Tzu Chi University of Science and Technology, Hualien 970, Taiwan.

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Nourrisson › Nouveau-né › Diosgenin Attenuates Myocardial Cell Apoptosis...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Diosgenin Attenuates Myocardial Cell Apoptosis...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines tumorales › Protéines oncogènes › Protéines proto-oncogènes › Protéines proto-oncogènes c-akt › Diosgenin Attenuates Myocardial Cell Apoptosis...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Récepteurs aux stéroïdes › Récepteurs des oestrogènes › Diosgenin Attenuates Myocardial Cell Apoptosis...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Phosphatidylinositol 3-kinases › Diosgenin Attenuates Myocardial Cell Apoptosis...
questionsmedicales.fr › Composés chimiques organiques › Radicaux libres › Peroxydes › Peroxyde d'hydrogène › Diosgenin Attenuates Myocardial Cell Apoptosis...
questionsmedicales.fr › Composés polycycliques › Composés à cycles fusionnés › Stéroïdes › Cholestanes › Spirostanes › Diosgénine › Diosgenin Attenuates Myocardial Cell Apoptosis...
questionsmedicales.fr › Maladies cardiovasculaires › Diosgenin Attenuates Myocardial Cell Apoptosis...
questionsmedicales.fr › Phénomènes physiologiques › Stress physiologique › Stress oxydatif › Diosgenin Attenuates Myocardial Cell Apoptosis...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Mort cellulaire › Mort cellulaire régulée › Apoptose › Diosgenin Attenuates Myocardial Cell Apoptosis...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Hormones, substituts d'hormones et antagonistes d'hormones › Hormones › Oestrogènes › Diosgenin Attenuates Myocardial Cell Apoptosis...
questionsmedicales.fr › Cellules › Cellules musculaires › Myocytes cardiaques › Diosgenin Attenuates Myocardial Cell Apoptosis...