Effects of bile duct ligation on the inhibitory control of supraoptic vasopressin neurons.
Rats
Male
Animals
Rats, Sprague-Dawley
Hyponatremia
/ metabolism
Chlorides
/ metabolism
Muscimol
/ metabolism
Vasopressins
/ metabolism
Arginine Vasopressin
/ metabolism
Neurons
/ metabolism
Supraoptic Nucleus
/ metabolism
Bile Ducts
/ surgery
Liver Cirrhosis
/ metabolism
Green Fluorescent Proteins
/ metabolism
gamma-Aminobutyric Acid
/ metabolism
GABA
chloride
hyponatremia
vasopressin
Journal
Journal of neuroendocrinology
ISSN: 1365-2826
Titre abrégé: J Neuroendocrinol
Pays: United States
ID NLM: 8913461
Informations de publication
Date de publication:
Jun 2023
Jun 2023
Historique:
revised:
02
05
2023
received:
17
02
2023
accepted:
11
05
2023
medline:
3
7
2023
pubmed:
20
6
2023
entrez:
19
6
2023
Statut:
ppublish
Résumé
Dilutional hyponatremia due to increased plasma arginine vasopressin (AVP) is associated with liver cirrhosis. However, plasma AVP remains elevated despite progressive hypoosmolality. This study investigated changes to inhibitory control of supraoptic nucleus (SON) AVP neurons during liver cirrhosis. Experiments were conducted with adult male Sprague-Dawley rats. Bile duct ligation was used as a model of chronic liver cirrhosis. An adeno-associated virus containing a construct with an AVP promoter and either green fluorescent protein (GFP) or a ratiometric chloride indicator, ClopHensorN, was bilaterally injected into the SON of rats. After 2 weeks, rats received either BDL or sham surgery, and liver cirrhosis was allowed to develop for 4 weeks. In vitro, loose patch recordings of action potentials were obtained from GFP-labeled and unlabeled SON neurons in response to a brief focal application of the GABA
Substances chimiques
Chlorides
0
Muscimol
2763-96-4
Vasopressins
11000-17-2
Arginine Vasopressin
113-79-1
Green Fluorescent Proteins
147336-22-9
gamma-Aminobutyric Acid
56-12-2
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e13312Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL142341
Pays : United States
Informations de copyright
© 2023 The Authors. Journal of Neuroendocrinology published by John Wiley & Sons Ltd on behalf of British Society for Neuroendocrinology.
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