Phages against Noncapsulated Klebsiella pneumoniae: Broader Host range, Slower Resistance.
Klebsiella pneumoniae
antimicrobial resistance
bacteriophage therapy
bacteriophage-bacteria interactions
bacteriophages
genomics
host range
in vivo
noncapsulated mutants
phage resistance
phage therapy
phage-bacteria interactions
Journal
Microbiology spectrum
ISSN: 2165-0497
Titre abrégé: Microbiol Spectr
Pays: United States
ID NLM: 101634614
Informations de publication
Date de publication:
17 08 2023
17 08 2023
Historique:
medline:
21
8
2023
pubmed:
20
6
2023
entrez:
20
6
2023
Statut:
ppublish
Résumé
Klebsiella pneumoniae (Kp), a human gut colonizer and opportunistic pathogen, is a major contributor to the global burden of antimicrobial resistance. Virulent bacteriophages represent promising agents for decolonization and therapy. However, the majority of anti-Kp phages that have been isolated thus far are highly specific to unique capsular types (anti-K phages), which is a major limitation to phage therapy prospects due to the highly polymorphic capsule of Kp. Here, we report on an original anti-Kp phage isolation strategy, using capsule-deficient Kp mutants as hosts (anti-K
Identifiants
pubmed: 37338376
doi: 10.1128/spectrum.04812-22
pmc: PMC10433977
doi:
Substances chimiques
Anti-Bacterial Agents
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0481222Déclaration de conflit d'intérêts
The authors declare a conflict of interest. The authors Brisse and Lourenço have submitted a patent application related to this work: EP22306064.1 “Bacteriophage(s) Targeting Capsular Deficient
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