White matter hyperintensities and smaller cortical thickness are associated with neuropsychiatric symptoms in neurodegenerative and cerebrovascular diseases.
Cerebrovascular disease
Cortical thickness
Neurodegenerative disease
Neuropsychiatric symptoms
White matter hyperintensities
Journal
Alzheimer's research & therapy
ISSN: 1758-9193
Titre abrégé: Alzheimers Res Ther
Pays: England
ID NLM: 101511643
Informations de publication
Date de publication:
20 06 2023
20 06 2023
Historique:
received:
13
09
2022
accepted:
01
06
2023
medline:
22
6
2023
pubmed:
21
6
2023
entrez:
20
6
2023
Statut:
epublish
Résumé
Neuropsychiatric symptoms (NPS) are a core feature of most neurodegenerative and cerebrovascular diseases. White matter hyperintensities and brain atrophy have been implicated in NPS. We aimed to investigate the relative contribution of white matter hyperintensities and cortical thickness to NPS in participants across neurodegenerative and cerebrovascular diseases. Five hundred thirteen participants with one of these conditions, i.e. Alzheimer's Disease/Mild Cognitive Impairment, Amyotrophic Lateral Sclerosis, Frontotemporal Dementia, Parkinson's Disease, or Cerebrovascular Disease, were included in the study. NPS were assessed using the Neuropsychiatric Inventory - Questionnaire and grouped into hyperactivity, psychotic, affective, and apathy subsyndromes. White matter hyperintensities were quantified using a semi-automatic segmentation technique and FreeSurfer cortical thickness was used to measure regional grey matter loss. Although NPS were frequent across the five disease groups, participants with frontotemporal dementia had the highest frequency of hyperactivity, apathy, and affective subsyndromes compared to other groups, whilst psychotic subsyndrome was high in both frontotemporal dementia and Parkinson's disease. Results from univariate and multivariate results showed that various predictors were associated with neuropsychiatric subsyndromes, especially cortical thickness in the inferior frontal, cingulate, and insula regions, sex(female), global cognition, and basal ganglia-thalamus white matter hyperintensities. In participants with neurodegenerative and cerebrovascular diseases, our results suggest that smaller cortical thickness and white matter hyperintensity burden in several cortical-subcortical structures may contribute to the development of NPS. Further studies investigating the mechanisms that determine the progression of NPS in various neurodegenerative and cerebrovascular diseases are needed.
Sections du résumé
BACKGROUND
Neuropsychiatric symptoms (NPS) are a core feature of most neurodegenerative and cerebrovascular diseases. White matter hyperintensities and brain atrophy have been implicated in NPS. We aimed to investigate the relative contribution of white matter hyperintensities and cortical thickness to NPS in participants across neurodegenerative and cerebrovascular diseases.
METHODS
Five hundred thirteen participants with one of these conditions, i.e. Alzheimer's Disease/Mild Cognitive Impairment, Amyotrophic Lateral Sclerosis, Frontotemporal Dementia, Parkinson's Disease, or Cerebrovascular Disease, were included in the study. NPS were assessed using the Neuropsychiatric Inventory - Questionnaire and grouped into hyperactivity, psychotic, affective, and apathy subsyndromes. White matter hyperintensities were quantified using a semi-automatic segmentation technique and FreeSurfer cortical thickness was used to measure regional grey matter loss.
RESULTS
Although NPS were frequent across the five disease groups, participants with frontotemporal dementia had the highest frequency of hyperactivity, apathy, and affective subsyndromes compared to other groups, whilst psychotic subsyndrome was high in both frontotemporal dementia and Parkinson's disease. Results from univariate and multivariate results showed that various predictors were associated with neuropsychiatric subsyndromes, especially cortical thickness in the inferior frontal, cingulate, and insula regions, sex(female), global cognition, and basal ganglia-thalamus white matter hyperintensities.
CONCLUSIONS
In participants with neurodegenerative and cerebrovascular diseases, our results suggest that smaller cortical thickness and white matter hyperintensity burden in several cortical-subcortical structures may contribute to the development of NPS. Further studies investigating the mechanisms that determine the progression of NPS in various neurodegenerative and cerebrovascular diseases are needed.
Identifiants
pubmed: 37340319
doi: 10.1186/s13195-023-01257-y
pii: 10.1186/s13195-023-01257-y
pmc: PMC10280981
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
114Investigateurs
Michael Strong
(M)
Peter Kleinstiver
(P)
Jane Lawrence-Dewar
(J)
Natalie Rashkovan
(N)
Susan Bronskil
(S)
Julia Fraser
(J)
Bill McIlroy
(B)
Ben Cornish
(B)
Karen Van Ooteghem
(K)
Frederico Faria
(F)
Yanina Sarquis-Adamson
(Y)
Alanna Black
(A)
Barry Greenberg
(B)
Wendy Hatch
(W)
Chris Hudson
(C)
Elena Leontieva
(E)
Ed Margolin
(E)
Efrem Mandelcorn
(E)
Faryan Tayyari
(F)
Sherif Defrawy
(S)
Don Brien
(D)
Ying Chen
(Y)
Brian Coe
(B)
Doug Munoz
(D)
Alisia Southwell
(A)
Dennis Bulman
(D)
Allison Ann Dilliott
(AA)
Mahdi Ghani
(M)
Rob Hegele
(R)
John Robinson
(J)
Ekaterina Rogaeva
(E)
Sali Farhan
(S)
Seyyed Mohammad Hassan Haddad
(SMH)
Nuwan Nanayakkara
(N)
Courtney Berezuk
(C)
Malcolm Binns
(M)
Wendy Lou
(W)
Athena Theyers
(A)
Abiramy Uthirakumaran
(A)
Guangyong Gy Zou
(GG)
Sujeevini Sujanthan
(S)
Mojdeh Zamyadi
(M)
David Munoz
(D)
Roger A Dixon
(RA)
John Woulfe
(J)
Brian Levine
(B)
J B Orange
(JB)
Alicia Peltsch
(A)
Angela Troyer
(A)
Marvin Chum
(M)
Informations de copyright
© 2023. The Author(s).
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