Smoking and tetramer tryptase accelerate intervertebral disc degeneration by inducing METTL14-mediated DIXDC1 m

Mice Animals Intervertebral Disc Degeneration / genetics Tryptases / metabolism Nucleus Pulposus / metabolism Wnt Signaling Pathway Smoking Intracellular Signaling Peptides and Proteins / metabolism
intervertebral disc low back pain mast cells smoking spine

Journal

Molecular therapy : the journal of the American Society of Gene Therapy
ISSN: 1525-0024
Titre abrégé: Mol Ther
Pays: United States
ID NLM: 100890581

Informations de publication

Date de publication:
02 08 2023
Historique:
received: 29 11 2022
revised: 24 04 2023
accepted: 14 06 2023
pmc-release: 02 08 2024
medline: 7 8 2023
pubmed: 21 6 2023
entrez: 21 6 2023
Statut: ppublish

Résumé

Although cigarette smoking (CS) and low back pain (LBP) are common worldwide, their correlations and the mechanisms of action remain unclear. We have shown that excessive activation of mast cells (MCs) and their proteases play key roles in CS-associated diseases, like asthma, chronic obstructive pulmonary disease (COPD), blood coagulation, and lung cancer. Previous studies have also shown that MCs and their proteases induce degenerative musculoskeletal disease. By using a custom-designed smoke-exposure mouse system, we demonstrated that CS results in intervertebral disc (IVD) degeneration and release of MC-restricted tetramer tryptases (TTs) in the IVDs. TTs were found to regulate the expression of methyltransferase 14 (METTL14) at the epigenetic level by inducing N6-methyladenosine (m

Identifiants

DOI: 10.1016/j.ymthe.2023.06.010 PMID: 37340635 PMC: PMC10422004
pubmed: 37340635
pii: S1525-0016(23)00321-0
doi: 10.1016/j.ymthe.2023.06.010
pmc: PMC10422004
pii:
doi:

Substances chimiques

Tryptases EC 3.4.21.59
Dixdc1 protein, mouse 0
Intracellular Signaling Peptides and Proteins 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

2524-2542

Informations de copyright

Copyright © 2023 The American Society of Gene and Cell Therapy. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of interests The authors declare no competing interests.

Références

J Proteome Res. 2012 Jul 6;11(7):3548-60
pubmed: 22616666
Ann Rheum Dis. 1973 Sep;32(5):406-12
pubmed: 4270883
J Biol Chem. 2022 Nov;298(11):102554
pubmed: 36183833
Nat Protoc. 2015 Aug;10(8):1198-211
pubmed: 26182239
J Biol Chem. 2001 Jul 13;276(28):26276-84
pubmed: 11335723
Eur Respir J. 2022 Jul 1;:
pubmed: 35777766
Osteoarthritis Cartilage. 2018 Jan;26(1):18-27
pubmed: 28888902
Mol Psychiatry. 2018 Feb;23(2):467-475
pubmed: 27752079
Am J Respir Crit Care Med. 2022 Feb 15;205(4):397-411
pubmed: 34813381
Spine (Phila Pa 1976). 2011 Jul 15;36(16):E1062-9
pubmed: 21358491
J Clin Invest. 1989 Nov;84(5):1657-62
pubmed: 2553780
J Biol Chem. 2007 Jul 20;282(29):20785-9
pubmed: 17504754
Algorithms Mol Biol. 2011 Nov 24;6:26
pubmed: 22115189
JCI Insight. 2018 Feb 8;3(3):
pubmed: 29415878
J Immunol. 2013 Aug 1;191(3):1404-12
pubmed: 23797671
Lancet. 2015 Mar 14;385(9972):966-76
pubmed: 25784347
Nature. 2021 Aug;596(7873):590-596
pubmed: 34293799
Stem Cells. 2005 Mar;23(3):403-11
pubmed: 15749935
J Biol Chem. 2017 Mar 31;292(13):5392-5404
pubmed: 28193842
J Orthop Sci. 2006 Mar;11(2):191-7
pubmed: 16568393
Pain Pract. 2011 Nov-Dec;11(6):552-63
pubmed: 21518246
Immunol Cell Biol. 2022 Apr;100(4):235-249
pubmed: 35175629
Am J Respir Crit Care Med. 2010 Feb 1;181(3):206-17
pubmed: 19926870
J Biol Chem. 2012 Mar 9;287(11):7834-44
pubmed: 22235124
Eur J Pain. 2013 Aug;17(7):957-71
pubmed: 23335362
JOR Spine. 2021 May 26;4(2):e1150
pubmed: 34337335
J Orthop Translat. 2021 Dec 15;31:126-138
pubmed: 34976732
Int J Biochem Cell Biol. 2013 Nov;45(11):2706-12
pubmed: 23932932
J Biol Chem. 2004 Sep 17;279(38):39366-73
pubmed: 15262978
Nat Rev Neurosci. 2019 Jul;20(7):380-396
pubmed: 31000796
Mol Ther Nucleic Acids. 2020 Dec 10;23:487-500
pubmed: 33510938
J Allergy Clin Immunol. 2013 Mar;131(3):752-62
pubmed: 23380220
Biochemistry. 2010 Apr 13;49(14):2987-98
pubmed: 20235548
Nat Rev Mol Cell Biol. 2019 Oct;20(10):608-624
pubmed: 31520073
FASEB J. 2020 Feb;34(2):1970-1982
pubmed: 31909538
Nat Biotechnol. 2008 Dec;26(12):1367-72
pubmed: 19029910
Arthritis Res Ther. 2013 Nov 14;15(6):R189
pubmed: 24286133
J Biol Chem. 1995 Mar 3;270(9):4689-96
pubmed: 7876240
J Orthop Res. 2018 Dec;36(12):3196-3207
pubmed: 30035326
J Orthop Translat. 2018 Aug 22;15:104-111
pubmed: 30564552
Osteoarthritis Cartilage. 2019 Sep;27(9):1347-1360
pubmed: 31132406
Int J Mol Med. 2016 Jun;37(6):1439-48
pubmed: 27121482
J Biol Chem. 2014 Jun 27;289(26):18214-27
pubmed: 24821729
Trends Cell Biol. 2018 Feb;28(2):113-127
pubmed: 29103884
Nat Rev Mol Cell Biol. 2017 Jan;18(1):31-42
pubmed: 27808276
J Clin Invest. 1997 Mar 15;99(6):1313-21
pubmed: 9077541
J Appl Physiol (1985). 2014 Jun 15;116(12):1551-60
pubmed: 24790018
Sci Rep. 2018 Jul 25;8(1):11191
pubmed: 30046041
Am J Respir Crit Care Med. 2012 Aug 1;186(3):233-9
pubmed: 22679009
Eur Respir J. 2019 Jul 18;54(1):
pubmed: 31196943
Curr Biol. 2003 Jan 8;13(1):73-7
pubmed: 12526749
Proc Natl Acad Sci U S A. 2005 Jul 26;102(30):10604-9
pubmed: 16009939
Adv Sci (Weinh). 2022 Jan;9(3):e2103631
pubmed: 34825784
J Exp Med. 1984 Oct 1;160(4):1027-42
pubmed: 6384417
Science. 2005 Sep 16;309(5742):1868-71
pubmed: 16166519
Nucleic Acids Res. 2016 Jun 2;44(10):e91
pubmed: 26896799
Nat Rev Rheumatol. 2013 Mar;9(3):136
pubmed: 23399689
Clin Exp Allergy. 1998 Dec;28(12):1509-17
pubmed: 10024222
J Hematol Oncol. 2020 Apr 10;13(1):35
pubmed: 32276589
Spine (Phila Pa 1976). 2012 Oct 1;37(21):1819-25
pubmed: 22343279
PLoS One. 2018 Jan 30;13(1):e0191611
pubmed: 29381718
Genome Res. 2002 Jun;12(6):996-1006
pubmed: 12045153
J Biol Chem. 2005 May 13;280(19):19185-95
pubmed: 15760903
J Immunol. 1998 Feb 15;160(4):1910-9
pubmed: 9469453
Neuron. 2010 Jul 15;67(1):33-48
pubmed: 20624590
JCI Insight. 2019 Jul 25;5:
pubmed: 31343988
Nat Rev Mol Cell Biol. 2018 Dec;19(12):774-790
pubmed: 30425324
Spine J. 2020 Sep;20(9):1492-1502
pubmed: 32413487
Nucleic Acids Res. 2019 Jan 8;47(D1):D729-D735
pubmed: 30462313
J Bone Miner Res. 2010 Jul;25(7):1468-86
pubmed: 20533309
J Biol Chem. 1999 Feb 5;274(6):3355-62
pubmed: 9920877
Mucosal Immunol. 2021 Mar;14(2):366-376
pubmed: 32814824
Nat Cell Biol. 2018 Mar;20(3):285-295
pubmed: 29476152
Respirology. 2017 Jan;22(1):21-32
pubmed: 27731525
Osteoarthritis Cartilage. 2022 Apr;30(4):613-625
pubmed: 35007741
Cancer Sci. 2010 Mar;101(3):700-6
pubmed: 20085589
Sci Transl Med. 2021 Nov 24;13(621):eaav7223
pubmed: 34818056
Spine (Phila Pa 1976). 2000 Apr 15;25(8):995-1014
pubmed: 10767814
J Biol Chem. 1994 Jul 8;269(27):18134-40
pubmed: 8027075
Insights Imaging. 2018 Apr;9(2):253-274
pubmed: 29569215
J Bone Miner Res. 2006 Sep;21(9):1409-16
pubmed: 16939399
Nucleic Acids Res. 2021 Jan 8;49(D1):D394-D403
pubmed: 33290554
Am J Respir Crit Care Med. 2021 Sep 15;204(6):667-681
pubmed: 34133911
Int J Biol Sci. 2009 Jun 03;5(5):388-96
pubmed: 19521550
Spine (Phila Pa 1976). 1999 Aug 1;24(15):1516-20
pubmed: 10457569
Mol Cell. 2014 Aug 7;55(3):436-50
pubmed: 25042806
Epigenomics. 2020 Aug;12(16):1419-1441
pubmed: 32627576
Nature. 2019 Mar;567(7748):414-419
pubmed: 30867593
J Orthop Res. 2012 Jun;30(6):950-7
pubmed: 22083942
Spine (Phila Pa 1976). 2011 Apr 15;36(8):E513-8
pubmed: 21270710
Elife. 2019 May 14;8:
pubmed: 31084709
Environ Int. 2020 Nov;144:106021
pubmed: 32791345
Nature. 2014 Jan 2;505(7481):117-20
pubmed: 24284625
Mol Biol Evol. 2017 Aug 1;34(8):2115-2122
pubmed: 28460117
Global Spine J. 2022 Jun;12(5):964-979
pubmed: 34018442

Auteurs

Ji Tu (J)

Spine Labs, St. George & Sutherland Clinical School, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia.

Wentian Li (W)

Spine Labs, St. George & Sutherland Clinical School, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia.

Philip M Hansbro (PM)

Faculty of Science, School of Life Sciences, Centre for Inflammation, Centenary Institute, University of Technology Sydney, Sydney, NSW, Australia; Priority Research Centre for Healthy Lungs, Hunter Medical Research Institute, University of Newcastle, Newcastle, NSW, Australia.

Qi Yan (Q)

Department of Orthopedic Surgery, The First Affiliated Hospital of Soochow University, Suzhou, China.

Xupeng Bai (X)

Center for Innovation and Translational Medicine, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China; Zhejiang Provincial Key Laboratory of Pancreatic Disease, First Affiliated Hospital, and Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou, China.

Chantal Donovan (C)

Faculty of Science, School of Life Sciences, Centre for Inflammation, Centenary Institute, University of Technology Sydney, Sydney, NSW, Australia; Priority Research Centre for Healthy Lungs, Hunter Medical Research Institute, University of Newcastle, Newcastle, NSW, Australia.

Richard Y Kim (RY)

Faculty of Science, School of Life Sciences, Centre for Inflammation, Centenary Institute, University of Technology Sydney, Sydney, NSW, Australia; Priority Research Centre for Healthy Lungs, Hunter Medical Research Institute, University of Newcastle, Newcastle, NSW, Australia.

Izabela Galvao (I)

Faculty of Science, School of Life Sciences, Centre for Inflammation, Centenary Institute, University of Technology Sydney, Sydney, NSW, Australia; Priority Research Centre for Healthy Lungs, Hunter Medical Research Institute, University of Newcastle, Newcastle, NSW, Australia.

Abhirup Das (A)

Spine Labs, St. George & Sutherland Clinical School, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia.

Cao Yang (C)

Department of Orthopedic Surgery, Wuhan Union Hospital, Tongji Medical School, Huazhong University of Science and Technology, Wuhan, China. Electronic address: caoyangunion@hust.edu.cn.

Jun Zou (J)

Department of Orthopedic Surgery, The First Affiliated Hospital of Soochow University, Suzhou, China. Electronic address: jzou@suda.edu.cn.

Ashish Diwan (A)

Spine Labs, St. George & Sutherland Clinical School, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia; Spine Service, Department of Orthopedic Surgery, St. George Hospital, Kogarah, NSW, Australia. Electronic address: a.diwan@unsw.edu.au.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Smoking and tetramer tryptase accelerate...
questionsmedicales.fr › Eucaryotes › Animaux › Smoking and tetramer tryptase accelerate...
questionsmedicales.fr › Maladies ostéomusculaires › Maladies osseuses › Maladies du rachis › Dégénérescence de disque intervertébral › Smoking and tetramer tryptase accelerate...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Peptide hydrolases › Protéases à sérine › Serine endopeptidases › Tryptases › Smoking and tetramer tryptase accelerate...
questionsmedicales.fr › Tissus › Tissu conjonctif › Cartilage › Fibrocartilage › Disque intervertébral › Nucleus pulposus › Smoking and tetramer tryptase accelerate...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › Voie de signalisation Wnt › Smoking and tetramer tryptase accelerate...
questionsmedicales.fr › Comportement et mécanismes comportementaux › Comportement › Fumer › Smoking and tetramer tryptase accelerate...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Smoking and tetramer tryptase accelerate...