Comparison of HBV DNA and RNA markers in Alaska Native people who did and did not clear hepatitis B surface antigen.
biomarkers
chronic hepatitis B
hepatitis B Core antigens
hepatitis B surface antigens
seroconversion
Journal
Journal of viral hepatitis
ISSN: 1365-2893
Titre abrégé: J Viral Hepat
Pays: England
ID NLM: 9435672
Informations de publication
Date de publication:
09 2023
09 2023
Historique:
revised:
08
06
2023
received:
31
03
2023
accepted:
10
06
2023
medline:
18
8
2023
pubmed:
22
6
2023
entrez:
22
6
2023
Statut:
ppublish
Résumé
In a comparison between 50 Alaska Native persons with chronic hepatitis B who cleared HBV surface antigen (HBsAg) and 50 Alaska Native age-, sex-, and HBV genotype-matched controls, we found differences in changes in HBV DNA and HBV RNA levels over time but no difference in hepatitis B core-related antigen. These findings suggest that serial HBV DNA and HBV RNA may be associated with HBV functional cure defined by HBsAg clearance.
Substances chimiques
Hepatitis B Surface Antigens
0
DNA, Viral
0
Hepatitis B Core Antigens
0
RNA
63231-63-0
Hepatitis B e Antigens
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
727-730Informations de copyright
© 2023 John Wiley & Sons Ltd.
Références
Alberta Health, public health and compliance division, Alberta immunization policy, Hepatitis B Virus Infection - High Endemic Geographic Areas. Accessed September 2, 2022, Available from: https://www.albertadoctors.org/Advocacy/Hepatitis_B_Endemic_Countries.pdf.
EASL clinical practice guidelines. Management of chronic hepatitis B virus infection. J Hepatol. 2012;57(1):167-185.
Suzuki F, Miyakoshi H, Kobayashi M, Kumada H. Correlation between serum hepatitis B virus core-related antigen and intrahepatic covalently closed circular DNA in chronic hepatitis B patients. J Med Virol. 2009;81(1):27-33.
Maasoumy B, Wiegand SB, Jaroszewicz J, et al. Hepatitis B core-related antigen (HBcrAg) levels in the natural history of hepatitis B virus infection in a large European cohort predominantly infected with genotypes a and D. Clin Microbiol Infect. 2015;21(6):606.e1-606.e10.
McMahon BJ, Nolen LD, Snowball M, et al. HBV genotype: a significant risk factor in determining which patients with chronic HBV infection should undergo surveillance for HCC: the hepatitis B Alaska study. Hepatology. 2021;74(6):2965-2973.
Barrett DH, Burks JM, McMahon B, et al. Epidemiology of hepatitis B in two Alaska communities. Am J Epidemiol. 1977;105(2):118-122.
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Meier MA, Calabrese D, Suslov A, Terracciano LM, Heim MH, Wieland S. Ubiquitous expression of HBsAg from integrated HBV DNA in patients with low viral load. J Hepatol. 2021;75(4):840-847.