Skin microbiome attributes associate with biophysical skin ageing.
collagen
microbiota
skin
skin ageing
Journal
Experimental dermatology
ISSN: 1600-0625
Titre abrégé: Exp Dermatol
Pays: Denmark
ID NLM: 9301549
Informations de publication
Date de publication:
09 2023
09 2023
Historique:
revised:
07
05
2023
received:
09
02
2023
accepted:
10
06
2023
medline:
11
9
2023
pubmed:
23
6
2023
entrez:
23
6
2023
Statut:
ppublish
Résumé
Two major arms of skin ageing are changes in the skin's biophysical conditions and alterations in the skin microbiome. This work partitioned both arms to study their interaction in detail. Leveraging the resolution provided by shotgun metagenomics, we explored how skin microbial species, strains and gene content interact with the biophysical traits of the skin during ageing. With a dataset well-controlled for confounding factors, we found that skin biophysical traits, especially the collagen diffusion coefficient, are associated with the composition and the functional potential of the skin microbiome, including the abundance of bacterial strains found in nosocomial infections and the abundance of antibiotic resistance genes. Our findings reveal important associations between skin biophysical features and ageing-related changes in the skin microbiome and generate testable hypotheses for the mechanisms of such associations.
Substances chimiques
Anti-Bacterial Agents
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
1546-1556Subventions
Organisme : NCI NIH HHS
ID : P30 CA034196
Pays : United States
Organisme : NIA NIH HHS
ID : R56 AG060746
Pays : United States
Organisme : NIGMS NIH HHS
ID : DP2 GM126893
Pays : United States
Organisme : NIAMS NIH HHS
ID : R01 AR078634
Pays : United States
Organisme : NIAMS NIH HHS
ID : R21 AR075174
Pays : United States
Informations de copyright
© 2023 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
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