Bioorthogonal Drug Release from Nanometric Micelles in Living Cells.
bioorthogonal reactions
drug release
micelles
nanoparticles
sydnonimines
Journal
Chemistry (Weinheim an der Bergstrasse, Germany)
ISSN: 1521-3765
Titre abrégé: Chemistry
Pays: Germany
ID NLM: 9513783
Informations de publication
Date de publication:
01 Aug 2023
01 Aug 2023
Historique:
received:
28
04
2023
medline:
2
8
2023
pubmed:
23
6
2023
entrez:
23
6
2023
Statut:
ppublish
Résumé
We explored a bioorthogonal approach to release drugs from stimuli-responsive micelles inside tumor cells. The concept relies on sydnonimine-based micelles that undergo quantitative cleavage in presence of cyclooctynes, hence releasing their content within living cells. Four cleavable micelles were developed to allow massive burst release of Entinostat, a potent histone deacetylase inhibitor, following their internalization inside cancer cells. A comparative study on the influence of the bioorthogonal-mediated versus passive drug release from micelles was carried out. The results indicated that a fast release of the drug triggered a stronger antiproliferative activity on tumor cells compared to the passive diffusion of the drug from the micelles core. These finding may be of great interest for the development of new nanomedicines.
Identifiants
pubmed: 37350524
doi: 10.1002/chem.202301359
doi:
Substances chimiques
Micelles
0
Drug Carriers
0
Doxorubicin
80168379AG
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e202301359Subventions
Organisme : Agence Nationale de la Recherche
ID : ANR-19-CE06-0006-01
Informations de copyright
© 2023 The Authors. Chemistry - A European Journal published by Wiley-VCH GmbH.
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