Apoprotein E methylation is correlated with immune microenvironment in hepatocellular carcinoma.

Humans Apolipoproteins E / genetics Apoproteins / genetics Carcinoma, Hepatocellular / genetics DNA Methylation Liver Neoplasms / pathology Prognosis Promoter Regions, Genetic RNA, Messenger / genetics Tumor Microenvironment
Apoprotein E DNA methylation hepatocellular carcinoma immune microenvironment

Journal

Acta oncologica (Stockholm, Sweden)
ISSN: 1651-226X
Titre abrégé: Acta Oncol
Pays: England
ID NLM: 8709065

Informations de publication

Date de publication:
Jun 2023
Historique:
medline: 24 7 2023
pubmed: 23 6 2023
entrez: 23 6 2023
Statut: ppublish

Résumé

We aimed to evaluate the correlation of apoprotein E (APOE) transcription and its methylation with immune microenvironment in HCC patients. The expression profiles of APOE transcription, APOE methylation, and APOE protein were investigated Based on data from TCGA, GEO, and ICGC datasets, the APOE mRNA was differentially expressed in HCC tissues compared with normal liver tissues. Further, APOE methylation was down-regulated in HCC tissues compared to normal liver tissues. APOE methylation was negatively correlated with APOE transcription in HCC ( APOE methylation had a closer correlation with immune cells than APOE mRNA, indicating that APOE methylation might play an important role in immune regulation in HCC.

Sections du résumé

BACKGROUND UNASSIGNED
We aimed to evaluate the correlation of apoprotein E (APOE) transcription and its methylation with immune microenvironment in HCC patients.
MATERIAL AND METHODS UNASSIGNED
The expression profiles of APOE transcription, APOE methylation, and APOE protein were investigated
RESULTS UNASSIGNED
Based on data from TCGA, GEO, and ICGC datasets, the APOE mRNA was differentially expressed in HCC tissues compared with normal liver tissues. Further, APOE methylation was down-regulated in HCC tissues compared to normal liver tissues. APOE methylation was negatively correlated with APOE transcription in HCC (
CONCLUSION UNASSIGNED
APOE methylation had a closer correlation with immune cells than APOE mRNA, indicating that APOE methylation might play an important role in immune regulation in HCC.

Identifiants

DOI: 10.1080/0284186X.2023.2225703 PMID: 37352133
pubmed: 37352133
doi: 10.1080/0284186X.2023.2225703
doi:

Substances chimiques

Apolipoproteins E 0
Apoproteins 0
RNA, Messenger 0
ApoE protein, human 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

550-559

Auteurs

Jiao Li (J)

Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan University, Wuhan, P.R. China.

Shan Tian (S)

Department of Infectious Diseases, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P.R. China.

Qi Liu (Q)

Department of Gastroenterology, The Affiliated Hospital of Guizhou Medical University, Guiyang, P.R. China.

Pailan Peng (P)

Department of Gastroenterology, The Affiliated Hospital of Guizhou Medical University, Guiyang, P.R. China.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Apoprotein E methylation is correlated with...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Lipoprotéines › Apolipoprotéines › Apolipoprotéines E › Apoprotein E methylation is correlated with...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Apoprotéines › Apoprotein E methylation is correlated with...
questionsmedicales.fr › Maladies de l'appareil digestif › Maladies du foie › Tumeurs du foie › Carcinome hépatocellulaire › Apoprotein E methylation is correlated with...
questionsmedicales.fr › Phénomènes génétiques › Méthylation de l'ADN › Apoprotein E methylation is correlated with...
questionsmedicales.fr › Maladies de l'appareil digestif › Maladies du foie › Tumeurs du foie › Apoprotein E methylation is correlated with...
questionsmedicales.fr › Diagnostic › Pronostic › Apoprotein E methylation is correlated with...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Composants de génome › Gènes › Composants de gène › Éléments de régulation transcriptionnelle › Régions promotrices (génétique) › Apoprotein E methylation is correlated with...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ARN › ARN messager › Apoprotein E methylation is correlated with...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Microenvironnement cellulaire › Microenvironnement tumoral › Apoprotein E methylation is correlated with...