Sex modifies the risk of HIV-associated obstructive lung disease in Ugandans postpneumonia.
Journal
AIDS (London, England)
ISSN: 1473-5571
Titre abrégé: AIDS
Pays: England
ID NLM: 8710219
Informations de publication
Date de publication:
01 09 2023
01 09 2023
Historique:
pmc-release:
01
09
2024
medline:
4
8
2023
pubmed:
23
6
2023
entrez:
23
6
2023
Statut:
ppublish
Résumé
Spirometric abnormalities are frequent, and obstructive lung disease (OLD) is a common comorbidity among people with HIV (PWH). HIV increases the risk of many comorbidities to a greater degree in women than in men. Few studies have evaluated whether sex modifies the HIV-associated risk of OLD. To evaluate the associations between sex and HIV with abnormal lung function, women and men with and without HIV underwent spirometric testing after completing therapy for pneumonia, including tuberculosis (TB), in Kampala, Uganda. OLD was defined as a postbronchodilator forced expiratory volume in the first second to forced vital capacity (FEV 1 /FVC) ratio less than 0.70. Associations between sex, HIV, and lung function were evaluated using multivariable regression models including sex-by-HIV interaction terms after adjusting for age, BMI, smoking status, and TB status. Among 348 participants, 147 (42%) were women and 135 (39%) were HIV-positive. Sixteen (11%) women and 23 men (11%) had OLD. The HIV-sex interaction was significant for obstructive lung disease ( P = 0.04). In the adjusted stratified analysis, women with HIV had 3.44 (95% CI 1.11-12.0; P = 0.04) increased odds of having OLD compared with men with HIV. Women without HIV did not have increased odds of having OLD compared with men without HIV. HIV appears to increase the risk of OLD to a greater degree in women than in men in an urban Ugandan setting. The mechanistic explanation for this interaction by sex remains unclear and warrants further study.
Identifiants
pubmed: 37352494
doi: 10.1097/QAD.0000000000003626
pii: 00002030-990000000-00281
pmc: PMC10527596
mid: NIHMS1909667
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
1683-1692Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL128156
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL143998
Pays : United States
Informations de copyright
Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved.
Références
J Acquir Immune Defic Syndr. 2016 Oct 1;73(2):123-9
pubmed: 27258230
NCHS Data Brief. 2011 Jun;(63):1-8
pubmed: 22142836
Cell Rep. 2020 Dec 8;33(10):108485
pubmed: 33296655
AIDS. 2015 Aug 24;29(13):1691-700
pubmed: 26372280
J Infect Dis. 2022 Apr 19;225(8):1348-1356
pubmed: 34417792
J Acquir Immune Defic Syndr. 2016 Feb 1;71(2):181-8
pubmed: 26361171
Curr Treat Options Cardiovasc Med. 2019 Jul 15;21(8):41
pubmed: 31309321
J Acquir Immune Defic Syndr. 2013 Nov 1;64(3):271-8
pubmed: 23979001
EBioMedicine. 2022 Sep;83:104182
pubmed: 35905559
Clin Chest Med. 2021 Sep;42(3):443-456
pubmed: 34353450
J Clin Endocrinol Metab. 2007 Jul;92(7):2506-12
pubmed: 17456578
AIDS. 2016 Sep 10;30(14):2185-93
pubmed: 27191979
Ann Am Thorac Soc. 2018 Feb;15(2):192-199
pubmed: 29313714
Lancet Respir Med. 2020 Jun;8(6):585-596
pubmed: 32526187
Eur Respir J. 2010 Nov;36(5):1034-41
pubmed: 20378599
Eur Respir J. 1997 Apr;10(4):822-7
pubmed: 9150319
Expert Rev Respir Med. 2021 Jan;15(1):71-87
pubmed: 33167728
Sci Immunol. 2018 Jan 26;3(19):
pubmed: 29374079
Lancet Healthy Longev. 2021 Apr;2(4):e202-e211
pubmed: 36098121
J Acquir Immune Defic Syndr. 2017 Jan 1;74(1):e23-e29
pubmed: 27716727
AIDS. 2018 Feb 20;32(4):487-493
pubmed: 29135579
Chest. 2006 Nov;130(5):1326-33
pubmed: 17099007
J Acquir Immune Defic Syndr. 2020 Feb 1;83(2):189-196
pubmed: 31929407
Lancet Glob Health. 2018 Feb;6(2):e193-e202
pubmed: 29254748
Thorax. 2023 Jun;78(6):535-542
pubmed: 36639241
Nat Med. 2009 Aug;15(8):955-9
pubmed: 19597505
Thorax. 2018 May;73(5):431-438
pubmed: 29331988
Clin Infect Dis. 2023 Feb 8;76(3):e727-e735
pubmed: 35604821
Front Immunol. 2021 Nov 11;12:756262
pubmed: 34858409
Open Forum Infect Dis. 2021 Nov 03;8(12):ofab558
pubmed: 34888399
Am J Respir Crit Care Med. 2017 May 1;195(9):1226-1235
pubmed: 28075609
Open Forum Infect Dis. 2022 May 11;9(7):ofac233
pubmed: 35836747
Eur Respir J. 2005 Aug;26(2):319-38
pubmed: 16055882
Am J Respir Crit Care Med. 2017 Jan 1;195(1):104-114
pubmed: 27447987
J Infect Dis. 2018 Aug 14;218(6):922-926
pubmed: 29718342
Ann Am Thorac Soc. 2022 Oct;19(10):1779-1783
pubmed: 35767026
J Acquir Immune Defic Syndr. 2013 Nov 1;64(3):284-8
pubmed: 23979000
J Infect Dis. 2013 Dec 1;208(11):1737-46
pubmed: 24041790
Curr Opin HIV AIDS. 2021 May 1;16(3):156-162
pubmed: 33797432
Respiration. 2021;100(8):751-763
pubmed: 33401266
AIDS. 2021 Jun 1;35(7):1031-1040
pubmed: 33635847
Physiol Rev. 2020 Apr 1;100(2):603-632
pubmed: 31600121
Am J Respir Crit Care Med. 2000 Dec;162(6):2152-8
pubmed: 11112130
J Acquir Immune Defic Syndr. 2018 Aug 15;78(5):543-548
pubmed: 29683991
Respiration. 2013;86(1):76-85
pubmed: 23652030
Curr HIV/AIDS Rep. 2017 Dec;14(6):220-228
pubmed: 29080122
Clin Infect Dis. 2021 Apr 26;72(8):1301-1311
pubmed: 32115628
Am J Respir Crit Care Med. 2011 Aug 15;184(4):414-20
pubmed: 21562134