Tryptophan metabolism in health and disease.
cancer
clinical feature
immune response
targeted therapies
tryptophan metabolism
Journal
Cell metabolism
ISSN: 1932-7420
Titre abrégé: Cell Metab
Pays: United States
ID NLM: 101233170
Informations de publication
Date de publication:
08 08 2023
08 08 2023
Historique:
received:
18
01
2023
revised:
10
04
2023
accepted:
05
06
2023
medline:
11
8
2023
pubmed:
24
6
2023
entrez:
23
6
2023
Statut:
ppublish
Résumé
Tryptophan (Trp) metabolism primarily involves the kynurenine, 5-hydroxytryptamine, and indole pathways. A variety of bioactive compounds produced via Trp metabolism can regulate various physiological functions, including inflammation, metabolism, immune responses, and neurological function. Emerging evidence supports an intimate relationship between Trp metabolism disorder and diseases. The levels or ratios of Trp metabolites are significantly associated with many clinical features. Additionally, studies have shown that disease progression can be controlled by modulating Trp metabolism. Indoleamine-2,3-dioxygenase, Trp-2,3-dioxygenase, kynurenine-3-monooxygenase, and Trp hydroxylase are the rate-limiting enzymes that are critical for Trp metabolism. These key regulatory enzymes can be targeted for treating several diseases, including tumors. These findings provide novel insights into the treatment of diseases. In this review, we have summarized the recent research progress on the role of Trp metabolites in health and disease along with their clinical applications.
Identifiants
pubmed: 37352864
pii: S1550-4131(23)00214-0
doi: 10.1016/j.cmet.2023.06.004
pii:
doi:
Substances chimiques
Kynurenine
343-65-7
Tryptophan
8DUH1N11BX
Dioxygenases
EC 1.13.11.-
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1304-1326Informations de copyright
Copyright © 2023 Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of interests The authors declare no competing interests.