Conditioned nausea induced by cisplatin and emetine identified by a taste reactivity test in rats.

Rats Animals Emetine / adverse effects Cisplatin / toxicity Saccharin / pharmacology Taste Lithium Chloride / pharmacology Nausea / chemically induced Avoidance Learning
Cisplatin Conditioned nausea Conditioned taste aversion Emetine Gaping Rats Taste reactivity test

Journal

Physiology & behavior
ISSN: 1873-507X
Titre abrégé: Physiol Behav
Pays: United States
ID NLM: 0151504

Informations de publication

Date de publication:
01 10 2023
Historique:
received: 05 04 2023
revised: 19 06 2023
accepted: 20 06 2023
medline: 24 7 2023
pubmed: 24 6 2023
entrez: 23 6 2023
Statut: ppublish

Résumé

No prior studies have shown that gaping reactions are produced with the avoidance of conditioned taste caused by cisplatin and emetine. Therefore, we tried to demonstrate it using a taste reactivity test in rats and found the gaping reactions induced when saccharin is readministered after gustatory conditioning that paired saccharin with cisplatin or emetine. Since conditioned gaping reactions indicate the aversion to saccharin taste and conditioned nausea, the present study suggest that the taste aversion is induced by cisplatin and emetine. It was also found that with intraperitoneal injections of emetine alone, gaping almost never occurs.

Identifiants

DOI: 10.1016/j.physbeh.2023.114278 PMID: 37352906
pubmed: 37352906
pii: S0031-9384(23)00203-2
doi: 10.1016/j.physbeh.2023.114278
pii:
doi:

Substances chimiques

Emetine X8D5EPO80M
Cisplatin Q20Q21Q62J
Saccharin FST467XS7D
Lithium Chloride G4962QA067

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

114278

Informations de copyright

Copyright © 2023 Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of Competing Interest The authors declare no conflicts of interest.

Auteurs

Shaoyi Su (S)

Oral Physiology, Department of Oral Functional Science, Division of Oral Medical Science, Faculty of Dental Medicine and Graduate school of Dental Medicine, Hokkaido University, Japan.

Zimo Wei (Z)

Oral Physiology, Department of Oral Functional Science, Division of Oral Medical Science, Faculty of Dental Medicine and Graduate school of Dental Medicine, Hokkaido University, Japan.

Helai Huang (H)

Oral Physiology, Department of Oral Functional Science, Division of Oral Medical Science, Faculty of Dental Medicine and Graduate school of Dental Medicine, Hokkaido University, Japan.

Tomohiko Yoshizawa (T)

Oral Physiology, Department of Oral Functional Science, Division of Oral Medical Science, Faculty of Dental Medicine and Graduate school of Dental Medicine, Hokkaido University, Japan.

Tadashi Inui (T)

Oral Physiology, Department of Oral Functional Science, Division of Oral Medical Science, Faculty of Dental Medicine and Graduate school of Dental Medicine, Hokkaido University, Japan.

Makoto Funahashi (M)

Oral Physiology, Department of Oral Functional Science, Division of Oral Medical Science, Faculty of Dental Medicine and Graduate school of Dental Medicine, Hokkaido University, Japan. Electronic address: mfuna@den.hokudai.ac.jp.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Conditioned nausea induced by cisplatin and...
questionsmedicales.fr › Eucaryotes › Animaux › Conditioned nausea induced by cisplatin and...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Isoquinoléines › Émétine › Conditioned nausea induced by cisplatin and...
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