ELAC2 is a functional prostate cancer risk allele.
ELAC2
prostate cancer
tRNA
translation control
Journal
Trends in molecular medicine
ISSN: 1471-499X
Titre abrégé: Trends Mol Med
Pays: England
ID NLM: 100966035
Informations de publication
Date de publication:
Aug 2023
Aug 2023
Historique:
received:
30
05
2023
accepted:
06
06
2023
pmc-release:
01
08
2024
medline:
17
7
2023
pubmed:
24
6
2023
entrez:
23
6
2023
Statut:
ppublish
Résumé
Stentenbach and colleagues have unveiled a functional role of a human germline mutation found in the ribonuclease (RNase) Z enzyme, ELAC2, in prostate cancer. Here, we discuss the importance of these findings in enhancing our understanding of how risk variants enable prostate cancer progression and the post-transcriptional mechanisms underlying oncogenesis.
Identifiants
pubmed: 37353407
pii: S1471-4914(23)00121-1
doi: 10.1016/j.molmed.2023.06.002
pmc: PMC10527048
mid: NIHMS1907104
pii:
doi:
Substances chimiques
ELAC2 protein, human
0
Neoplasm Proteins
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
586-588Subventions
Organisme : NCI NIH HHS
ID : R01 CA276308
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM135362
Pays : United States
Organisme : NCI NIH HHS
ID : R37 CA230617
Pays : United States
Organisme : NCI NIH HHS
ID : T32 CA009515
Pays : United States
Informations de copyright
Copyright © 2023 Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of interests No interests are declared.
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