3D Bioprinting in Microgravity: Opportunities, Challenges, and Possible Applications in Space.


Journal

Advanced healthcare materials
ISSN: 2192-2659
Titre abrégé: Adv Healthc Mater
Pays: Germany
ID NLM: 101581613

Informations de publication

Date de publication:
09 2023
Historique:
revised: 12 05 2023
received: 10 02 2023
medline: 14 9 2023
pubmed: 24 6 2023
entrez: 24 6 2023
Statut: ppublish

Résumé

3D bioprinting has developed tremendously in the last couple of years and enables the fabrication of simple, as well as complex, tissue models. The international space agencies have recognized the unique opportunities of these technologies for manufacturing cell and tissue models for basic research in space, in particular for investigating the effects of microgravity and cosmic radiation on different types of human tissues. In addition, bioprinting is capable of producing clinically applicable tissue grafts, and its implementation in space therefore can support the autonomous medical treatment options for astronauts in future long term and far-distant space missions. The article discusses opportunities but also challenges of operating different types of bioprinters under space conditions, mainly in microgravity. While some process steps, most of which involving the handling of liquids, are challenging under microgravity, this environment can help overcome problems such as cell sedimentation in low viscous bioinks. Hopefully, this publication will motivate more researchers to engage in the topic, with publicly available bioprinting opportunities becoming available at the International Space Station (ISS) in the imminent future.

Identifiants

pubmed: 37353904
doi: 10.1002/adhm.202300443
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

e2300443

Informations de copyright

© 2023 The Authors. Advanced Healthcare Materials published by Wiley-VCH GmbH.

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Auteurs

Angelique Van Ombergen (A)

SciSpacE Team, Directorate of Human and Robotic Exploration Programmes (HRE), European Space Agency (ESA), Keplerlaan 1, Noordwijk, 2201AG, The Netherlands.
ESA Topical Team on "3D Bioprinting of living tissue for utilization in space exploration and extraterrestrial human settlements", 01307, Dresden, Germany.

Franziska Chalupa-Gantner (F)

Research Group 3D Printing and Biofabrication, Institute of Materials Science and Technology, Austrian Cluster for Tissue Regeneration, TU Wien, Getreidemarkt 9/E308, Vienna, 1060, Austria.

Parth Chansoria (P)

Tissue Engineering + Biofabrication Laboratory, Department of Health Sciences and Technology, ETH Zurich Otto-Stern-Weg 7, Zürich, 8093, Switzerland.

Bianca Maria Colosimo (BM)

ESA Topical Team on "3D Bioprinting of living tissue for utilization in space exploration and extraterrestrial human settlements", 01307, Dresden, Germany.
Department of Mechanical Engineering, Politecnico di Milano, Via La Masa 1, Milano, 20156, Italy.

Marco Costantini (M)

Institute of Physical Chemistry, Polish Academy of Sciences, Ul. Kasprzaka 44/52, Warsaw, 01-224, Poland.

Marco Domingos (M)

ESA Topical Team on "3D Bioprinting of living tissue for utilization in space exploration and extraterrestrial human settlements", 01307, Dresden, Germany.
Department of Mechanical, Aerospace and Civil Engineering, School of Engineering, Faculty of Science and Engineering & Henry Royce Institute, University of Manchester, M13 9PL, Manchester, UK.

Alexandre Dufour (A)

3d.FAB - ICBMS, CNRS UMR 5246, University Claude Bernard-Lyon 1 and University of Lyon, 1 rue Victor Grignard, Villeurbanne, 69100, France.

Carmelo De Maria (C)

Department of Information Engineering (DII) and Research Center "E. Piaggio", University of Pisa, Largo Lucio Lazzarino 1, Pisa, 56122, Italy.

Jürgen Groll (J)

ESA Topical Team on "3D Bioprinting of living tissue for utilization in space exploration and extraterrestrial human settlements", 01307, Dresden, Germany.
Department of Functional Materials in Medicine and Dentistry at the Institute of Functional Materials and Biofabrication (IFB) and Bavarian Polymer Institute (BPI), University of Würzburg, Pleicherwall 2, 97070, Würzburg, Germany.

Tomasz Jungst (T)

Department of Functional Materials in Medicine and Dentistry at the Institute of Functional Materials and Biofabrication (IFB) and Bavarian Polymer Institute (BPI), University of Würzburg, Pleicherwall 2, 97070, Würzburg, Germany.

Riccardo Levato (R)

Department of Orthopaedics, University Medical Center Utrecht, Department of Clinical Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, 3584 CX, The Netherlands.

Jos Malda (J)

ESA Topical Team on "3D Bioprinting of living tissue for utilization in space exploration and extraterrestrial human settlements", 01307, Dresden, Germany.
Department of Orthopaedics, University Medical Center Utrecht, Department of Clinical Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, 3584 CX, The Netherlands.

Alessandro Margarita (A)

Department of Mechanical Engineering, Politecnico di Milano, Via La Masa 1, Milano, 20156, Italy.

Christophe Marquette (C)

ESA Topical Team on "3D Bioprinting of living tissue for utilization in space exploration and extraterrestrial human settlements", 01307, Dresden, Germany.
3d.FAB - ICBMS, CNRS UMR 5246, University Claude Bernard-Lyon 1 and University of Lyon, 1 rue Victor Grignard, Villeurbanne, 69100, France.

Aleksandr Ovsianikov (A)

ESA Topical Team on "3D Bioprinting of living tissue for utilization in space exploration and extraterrestrial human settlements", 01307, Dresden, Germany.
Research Group 3D Printing and Biofabrication, Institute of Materials Science and Technology, Austrian Cluster for Tissue Regeneration, TU Wien, Getreidemarkt 9/E308, Vienna, 1060, Austria.

Emma Petiot (E)

3d.FAB - ICBMS, CNRS UMR 5246, University Claude Bernard-Lyon 1 and University of Lyon, 1 rue Victor Grignard, Villeurbanne, 69100, France.

Sophia Read (S)

Department of Mechanical, Aerospace and Civil Engineering, School of Engineering, Faculty of Science and Engineering & Henry Royce Institute, University of Manchester, M13 9PL, Manchester, UK.

Leonardo Surdo (L)

ESA Topical Team on "3D Bioprinting of living tissue for utilization in space exploration and extraterrestrial human settlements", 01307, Dresden, Germany.
Space Applications Services NV/SA for the European Space Agency (ESA), Keplerlaan 1, Noordwijk, 2201AG, The Netherlands.

Wojciech Swieszkowski (W)

ESA Topical Team on "3D Bioprinting of living tissue for utilization in space exploration and extraterrestrial human settlements", 01307, Dresden, Germany.
Biomaterials Group, Materials Design Division, Faculty of Materials Science and Engineering, Warsaw University of Technology, Woloska Str. 141, Warsaw, 02-507, Poland.

Giovanni Vozzi (G)

ESA Topical Team on "3D Bioprinting of living tissue for utilization in space exploration and extraterrestrial human settlements", 01307, Dresden, Germany.
Department of Information Engineering (DII) and Research Center "E. Piaggio", University of Pisa, Largo Lucio Lazzarino 1, Pisa, 56122, Italy.

Johannes Windisch (J)

Centre for Translational Bone, Joint and Soft Tissue Research, University Hospital and Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden, Fetscherstr. 74, 01307, Dresden, Germany.

Marcy Zenobi-Wong (M)

ESA Topical Team on "3D Bioprinting of living tissue for utilization in space exploration and extraterrestrial human settlements", 01307, Dresden, Germany.
Tissue Engineering + Biofabrication Laboratory, Department of Health Sciences and Technology, ETH Zurich Otto-Stern-Weg 7, Zürich, 8093, Switzerland.

Michael Gelinsky (M)

ESA Topical Team on "3D Bioprinting of living tissue for utilization in space exploration and extraterrestrial human settlements", 01307, Dresden, Germany.
Centre for Translational Bone, Joint and Soft Tissue Research, University Hospital and Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden, Fetscherstr. 74, 01307, Dresden, Germany.

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