Evaluation of aggression level in adolescent girls with classical congenital adrenal hyperplasia.
Buss-Perry Aggression Scale
adolescent
aggression
congenital adrenal hyperplasia
Journal
Clinical endocrinology
ISSN: 1365-2265
Titre abrégé: Clin Endocrinol (Oxf)
Pays: England
ID NLM: 0346653
Informations de publication
Date de publication:
08 2023
08 2023
Historique:
revised:
06
04
2023
received:
06
12
2022
accepted:
30
04
2023
medline:
6
7
2023
pubmed:
26
6
2023
entrez:
26
6
2023
Statut:
ppublish
Résumé
In patients with classical congenital adrenal hyperplasia (CAH), virilization affects the brain and external genitalia due to antenatal androgen exposure. There are few studies on how the effects of androgens on brain virilization are reflected in behavior. However, there is no study focused on the adolescence period. The aim of this study was to evaluate the level of aggression in adolescent girls with classical CAH (due to 21 hydroxylase and 11β hydroxylase deficiency) and to investigate the disease-related factors that may affect aggression. Twenty female and 20 male patients aged 13-20 years, diagnosed with classical CAH, with 21 hydroxylase deficiency and 11β hydroxylase deficiency, and 20 healthy girls and 20 boys from the same age group were included. The Buss-Perry Aggression Scale (BPAS), which consists of four subgroups measuring physical aggression, verbal aggression, hostility, and angry behaviors, was used. The ages of the male and female patients with CAH were 16.30 ± 2.65 and 16.60 ± 2.41 years, respectively. Total aggression scale scores were 73.3 ± 14.6 in adolescent girls with CAH, 74.1 ± 11.2 in healthy girls, 71.5 ± 14.8 in boys with CAH, and 75.3 ± 14.5 in healthy boys (p > .05). There was no difference between the subscale scores of patients and healthy adolescents. Aggression scores in adolescents with CAH increased significantly with age. In this study, we found no difference between the aggression scores of adolescents with classical CAH compared to their healthy peers. The total aggression score and subscale were similar in unaffected female adolescents.
Substances chimiques
Steroid 21-Hydroxylase
EC 1.14.14.16
Androgens
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
135-141Informations de copyright
© 2023 The Authors. Clinical Endocrinology published by John Wiley & Sons Ltd.
Références
Speiser PW, Azziz R, Baskin LS, et al. Congenital adrenal hyperplasia due to steroid 21-hydroxylase deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2010;95(9):4133-4160.
White PC, Speiser PW, White PC. Congenital adrenal hyperplasia due to 21-hydroxylase deficiency. Endocr Rev. 2000;21(3):245-291.
McCarthy M, De Vries G, Forger N. Sexual differentiation of the brain: mode, mechanisms, and meaning. 2009.
Arnold AP. The organizational-activational hypothesis as the foundation for a unified theory of sexual differentiation of all mammalian tissues. Horm Behav. 2009;55(5):570-578.
Hines M. Prenatal endocrine influences on sexual orientation and on sexually differentiated childhood behavior. Front Neuroendocrinol. 2011;32(2):170-182.
Speiser PW, Dupont B, Rubinstein P, Piazza A, Kastelan A, New MI. High frequency of nonclassical steroid 21-hydroxylase deficiency. Am J Hum Genet. 1985;37(4):650-667.
van Wingen G, Mattern C, Verkes RJ, Buitelaar J, Fernández G. Testosterone reduces amygdala-orbitofrontal cortex coupling. Psychoneuroendocrinology. 2010;35(1):105-113.
Herting MM, Azad A, Kim R, Tyszka JM, Geffner ME, Kim MS. Brain differences in the prefrontal cortex, amygdala, and hippocampus in youth with congenital adrenal hyperplasia. J Clin Endocrinol Metab. 2020;105(4):1098-1111.
Webb EA, Elliott L, Carlin D, et al. Quantitative brain MRI in congenital adrenal hyperplasia: in vivo assessment of the cognitive and structural impact of steroid hormones. J Clin Endocrinol Metab. 2018;103(4):1330-1341.
Mazzone L, Mueller SC, Maheu F, VanRyzin C, Merke DP, Ernst M. Emotional memory in early steroid abnormalities: an FMRI study of adolescents with congenital adrenal hyperplasia. Dev Neuropsychol. 2011;36(4):473-492.
Pasterski V, Geffner ME, Brain C, Hindmarsh P, Brook C, Hines M. Prenatal hormones and childhood sex segregation: playmate and play style preferences in girls with congenital adrenal hyperplasia. Horm Behav. 2011;59(4):549-555.
Hines M, Kaufman FR. Androgen and the development of human sex-typical behavior: rough-and-tumble play and sex of preferred playmates in children with congenital adrenal hyperplasia (CAH). Child Dev. 1994;65(4):1042-1053.
Berenbaum SA, Hines M. Early androgens are related to childhood sex-typed toy preferences. Psychol Sci. 1992;3(3):203-206.
Pasterski V, Hindmarsh P, Geffner M, Brook C, Brain C, Hines M. Increased aggression and activity level in 3-to 11-year-old girls with congenital adrenal hyperplasia (CAH). Horm Behav. 2007;52(3):368-374.
Buss AH, Perry M. The aggression questionnaire. J Pers Soc Psychol. 1992;63(3):452-459.
Madran Psik, Andac H. The reliability and validity of the Buss-Perry Aggression Questionnaire (BAQ)-Turkish version. Turk Psikiyatri Dergisi. 2013;24(2):124.
Pasterski VL, Geffner ME, Brain C, Hindmarsh P, Brook C, Hines M. Prenatal hormones and postnatal socialization by parents as determinants of male-typical toy play in girls with congenital adrenal hyperplasia. Child Dev. 2005;76(1):264-278.
Oner O, Aycan Z, Tiryaki T, Soy D, Cetinkaya E, Kibar E. Variables related to behavioral and emotional problems and gender typed behaviors in female patients with congenital adrenal hyperplasia. J Pediatr Endocrinol Metab. 2009;22(2):143-152.
Mathews GA, Fane BA, Conway GS, Brook CGD, Hines M. Personality and congenital adrenal hyperplasia: possible effects of prenatal androgen exposure. Horm Behav. 2009;55(2):285-291.