Postnatal expression of CD38 in astrocytes regulates synapse formation and adult social memory.
astrocyte
cADPR
calcium
prefrontal cortex
social behavior
Journal
The EMBO journal
ISSN: 1460-2075
Titre abrégé: EMBO J
Pays: England
ID NLM: 8208664
Informations de publication
Date de publication:
01 08 2023
01 08 2023
Historique:
revised:
23
05
2023
received:
23
03
2022
accepted:
31
05
2023
pmc-release:
26
06
2024
medline:
2
8
2023
pubmed:
26
6
2023
entrez:
26
6
2023
Statut:
ppublish
Résumé
Social behavior is essential for health, survival, and reproduction of animals; however, the role of astrocytes in social behavior remains largely unknown. The transmembrane protein CD38, which acts both as a receptor and ADP-ribosyl cyclase to produce cyclic ADP-ribose (cADPR) regulates social behaviors by promoting oxytocin release from hypothalamic neurons. CD38 is also abundantly expressed in astrocytes in the postnatal brain and is important for astroglial development. Here, we demonstrate that the astroglial-expressed CD38 plays an important role in social behavior during development. Selective deletion of CD38 in postnatal astrocytes, but not in adult astrocytes, impairs social memory without any other behavioral abnormalities. Morphological analysis shows that depletion of astroglial CD38 in the postnatal brain interferes with synapse formation in the medial prefrontal cortex (mPFC) and hippocampus. Moreover, astroglial CD38 expression promotes synaptogenesis of excitatory neurons by increasing the level of extracellular SPARCL1 (also known as Hevin), a synaptogenic protein. The release of SPARCL1 from astrocytes is regulated by CD38/cADPR/calcium signaling. These data demonstrate a novel developmental role of astrocytes in neural circuit formation and regulation of social behavior in adults.
Identifiants
pubmed: 37357972
doi: 10.15252/embj.2022111247
pmc: PMC10390870
doi:
Substances chimiques
ADP-ribosyl Cyclase 1
EC 3.2.2.6
Antigens, CD
0
Cyclic ADP-Ribose
119340-53-3
Membrane Glycoproteins
0
Banques de données
GEO
['GSE216887']
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e111247Informations de copyright
© 2023 The Authors.
Références
Nat Commun. 2017 Feb 10;8:14336
pubmed: 28186121
Nature. 2007 Mar 1;446(7131):41-5
pubmed: 17287729
Hum Mol Genet. 2013 Jan 1;22(1):96-109
pubmed: 23026749
Trends Neurosci. 2021 Mar;44(3):227-240
pubmed: 33246578
Cell. 2005 Feb 11;120(3):421-33
pubmed: 15707899
Nature. 2014 Apr 3;508(7494):88-92
pubmed: 24572357
J Neurochem. 2014 Aug;130(3):374-87
pubmed: 24697507
Science. 2007 Feb 23;315(5815):1143-7
pubmed: 17289941
Mol Brain. 2016 Feb 09;9:16
pubmed: 26856703
J Neurosci. 2020 Oct 14;40(42):8088-8102
pubmed: 32973045
Transgenic Res. 2015 Dec;24(6):1065-77
pubmed: 26395370
Biol Psychiatry. 2021 Mar 1;89(5):521-531
pubmed: 33190846
Neurobiol Dis. 2007 Jul;27(1):77-89
pubmed: 17532643
J Biol Chem. 1999 Jan 22;274(4):1869-72
pubmed: 9890936
Glia. 2020 Nov;68(11):2395-2414
pubmed: 32497340
Elife. 2014 Dec 17;3:
pubmed: 25517933
Nucleic Acids Res. 2019 Jan 8;47(D1):D745-D751
pubmed: 30407521
J Proteome Res. 2009 Aug;8(8):4135-43
pubmed: 19469553
Nat Biotechnol. 2013 Jan;31(1):46-53
pubmed: 23222703
Nat Neurosci. 2016 Apr 26;19(6):647-655
pubmed: 29323671
EMBO J. 2021 Nov 2;40(21):e107532
pubmed: 34549820
Physiol Rev. 2008 Jul;88(3):841-86
pubmed: 18626062
EMBO J. 2023 Aug 1;42(15):e111247
pubmed: 37357972
Curr Opin Neurobiol. 2017 Aug;45:113-120
pubmed: 28570864
Glia. 2017 Jun;65(6):974-989
pubmed: 28295574
Cell. 2016 Jan 14;164(1-2):183-196
pubmed: 26771491
Nat Neurosci. 2015 Mar;18(3):423-34
pubmed: 25622143
Neurosci Biobehav Rev. 2020 Nov;118:331-357
pubmed: 32768488
FASEB J. 2019 May;33(5):5823-5835
pubmed: 30844310
Glia. 2006 Jul;54(1):21-34
pubmed: 16652340
Neural Dev. 2018 May 1;13(1):7
pubmed: 29712572
Front Psychiatry. 2013 Feb 25;4:4
pubmed: 23444313
Sci Rep. 2021 Mar 8;11(1):5437
pubmed: 33686099
Nature. 2016 Mar 10;531(7593):185-90
pubmed: 26934224
Annu Rev Pharmacol Toxicol. 2001;41:317-45
pubmed: 11264460
iScience. 2020 Mar 27;23(3):100894
pubmed: 32092698
PLoS One. 2020 Dec 16;15(12):e0244022
pubmed: 33326496
Curr Protoc Neurosci. 2019 Jun;88(1):e71
pubmed: 31216394
Cell Stem Cell. 2013 Mar 7;12(3):342-53
pubmed: 23472873
Proc Jpn Acad Ser B Phys Biol Sci. 2021;97(8):423-461
pubmed: 34629354
J Neurosci Methods. 1985 Aug;14(3):149-67
pubmed: 2864480
Neuron. 2017 Aug 2;95(3):531-549.e9
pubmed: 28712653
Cell. 2019 May 16;177(5):1280-1292.e20
pubmed: 31031006
Front Neurosci. 2015 Oct 09;9:344
pubmed: 26500475
Front Behav Neurosci. 2019 Oct 01;13:233
pubmed: 31632251
Cold Spring Harb Perspect Biol. 2015 Feb 06;7(9):a020370
pubmed: 25663667
Mol Brain. 2016 Dec 13;9(1):98
pubmed: 27964753
Elife. 2021 May 05;10:
pubmed: 33949949
Glia. 2017 Jun;65(6):990-1004
pubmed: 28317180
Bioinformatics. 2013 Jan 1;29(1):15-21
pubmed: 23104886
Nat Rev Neurosci. 2013 Jan;14(1):7-23
pubmed: 23254191
FEBS J. 2005 Sep;272(18):4590-7
pubmed: 16156781
Brain Sci. 2017 Oct 16;7(10):
pubmed: 29035307
Nature. 2016 Jul 27;535(7613):551-5
pubmed: 27466127
J Proteome Res. 2010 May 7;9(5):2764-74
pubmed: 20329800
Nat Neurosci. 2013 May;16(5):580-6
pubmed: 23542688
Neuron. 2007 Oct 4;56(1):58-65
pubmed: 17920015
Neuron. 2018 Apr 4;98(1):16-30
pubmed: 29621486
Mol Cell Neurosci. 2004 Nov;27(3):306-21
pubmed: 15519245
Nature. 2020 Nov;587(7833):264-269
pubmed: 32968277
Neuroscience. 2018 Feb 21;372:114-125
pubmed: 29306053
J Chem Neuroanat. 2013 Nov;53:1-10
pubmed: 23912123
J Neuroendocrinol. 2013 Feb;25(2):107-18
pubmed: 22967062
J Neuroimmune Pharmacol. 2008 Sep;3(3):154-64
pubmed: 18581239
Science. 2016 Sep 30;353(6307):1536-1541
pubmed: 27708103
Curr Opin Neurobiol. 2014 Feb;24(1):176-89
pubmed: 24419141
Nat Methods. 2021 Apr;18(4):374-377
pubmed: 33795878
Mol Psychiatry. 2007 Apr;12(4):398-407
pubmed: 17389905