Case Report: Intercurrent infections in COVID-19-induced sustained immunodepression: is interferon gamma a suitable drug?
ARDS (acute respiratory disease syndrome)
COVID 19
HLA-DR
acute immuno-depression syndrome
interferon gamma (IFNγ)
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2023
2023
Historique:
received:
10
03
2023
accepted:
15
05
2023
medline:
28
6
2023
pubmed:
26
6
2023
entrez:
26
6
2023
Statut:
epublish
Résumé
Acute immuno-depression syndrome (AIDs) had been observed in many life-threatening conditions leading to the Intensive Care Unit. and is associated with recurrent secondary infections. We report one COVID-19 patient with a severe ARDS, demonstrating acute immunodepression syndrome lasting for several weeks. The occurrence of secondary infections despite long treatment by antibiotics led to combined interferon γ (IFNγ) as reported previously. The response to IFNγ was evaluated by the flowcytometry HLA-DR expression on circulating monocytes, which was repeated from time to time. The severe COVID-19 patients responded well to IFNγ without adverse events.
Identifiants
pubmed: 37359519
doi: 10.3389/fimmu.2023.1183665
pmc: PMC10285411
doi:
Substances chimiques
Interferon-gamma
82115-62-6
HLA-DR Antigens
0
Types de publication
Case Reports
Langues
eng
Sous-ensembles de citation
IM
Pagination
1183665Informations de copyright
Copyright © 2023 De Waard, Lefebvre, Textoris and Payen.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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