Insights into the Pharmacological Activity of the Imidazo-Pyrazole Scaffold.
ROS
anticancer activity
imidazo−pyrazoles
medicinal chemistry
molecular docking
Journal
ChemMedChem
ISSN: 1860-7187
Titre abrégé: ChemMedChem
Pays: Germany
ID NLM: 101259013
Informations de publication
Date de publication:
01 09 2023
01 09 2023
Historique:
revised:
21
06
2023
received:
08
05
2023
medline:
4
9
2023
pubmed:
27
6
2023
entrez:
27
6
2023
Statut:
ppublish
Résumé
In previous studies, we synthesized different imidazo-pyrazoles 1 and 2 with interesting anticancer, anti-angiogenic and anti-inflammatory activities. To further extend the structure-activity relationships of imidazo-pyrazole scaffold and to identify novel antiproliferative/anti-inflammatory agents potentially active with multi-target mechanisms, a library of compounds 3-5 has been designed and synthesized. The chemical modifications characterizing the novel derivatives include: i) decoration of the catechol ring with groups with different electronic, steric and lipophilic properties (compounds 3); ii) insertion of a methyl group on C-6 of imidazo-pyrazole scaffold (compounds 4); iii) shift of the acylhydrazonic substituent from position 7 to 6 of the imidazo-pyrazole substructure (compounds 5). All synthesized compounds were tested against a panel of cancer and normal cell lines. Derivatives 3 a, 3 e, 4 c, 5 g and 5 h showed IC
Identifiants
pubmed: 37366115
doi: 10.1002/cmdc.202300252
doi:
Substances chimiques
pyrazole
3QD5KJZ7ZJ
Tubulin
0
Pyrazoles
0
Antineoplastic Agents
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e202300252Informations de copyright
© 2023 The Authors. ChemMedChem published by Wiley-VCH GmbH.
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