Gamma secretase activating protein promotes end-organ dysfunction after bacterial pneumonia.
acute lung injury
beta amyloid
long-term potentiation
myocardial infarction
pneumonia
Journal
American journal of physiology. Lung cellular and molecular physiology
ISSN: 1522-1504
Titre abrégé: Am J Physiol Lung Cell Mol Physiol
Pays: United States
ID NLM: 100901229
Informations de publication
Date de publication:
01 08 2023
01 08 2023
Historique:
medline:
4
8
2023
pubmed:
27
6
2023
entrez:
27
6
2023
Statut:
ppublish
Résumé
Pneumonia elicits the production of cytotoxic beta amyloid (Aβ) that contributes to end-organ dysfunction, yet the mechanism(s) linking infection to activation of the amyloidogenic pathway that produces cytotoxic Aβ is unknown. Here, we tested the hypothesis that gamma-secretase activating protein (GSAP), which contributes to the amyloidogenic pathway in the brain, promotes end-organ dysfunction following bacterial pneumonia. First-in-kind
Identifiants
pubmed: 37366533
doi: 10.1152/ajplung.00018.2023
pmc: PMC10396227
doi:
Substances chimiques
Amyloid Precursor Protein Secretases
EC 3.4.-
Amyloid beta-Peptides
0
Neurotransmitter Agents
0
Banques de données
figshare
['10.6084/m9.figshare.23304029.v2']
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
L174-L189Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL160988
Pays : United States
Organisme : NIH HHS
ID : S10 OD025089
Pays : United States
Organisme : NHLBI NIH HHS
ID : P01 HL066299
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL118334
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL140182
Pays : United States
Organisme : NHLBI NIH HHS
ID : F31 HL147512
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL148069
Pays : United States
Organisme : NHLBI NIH HHS
ID : P01 HL116264
Pays : United States
Organisme : NIA NIH HHS
ID : K99 AG058780
Pays : United States
Organisme : NIH HHS
ID : R21 OD026560
Pays : United States
Organisme : NHLBI NIH HHS
ID : T32 HL007778
Pays : United States
Organisme : NIA NIH HHS
ID : R00 AG058780
Pays : United States
Organisme : NIH HHS
ID : R01 OD010944
Pays : United States
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