Sex differences in neuroendocrine, sympathetic nervous system, and affect responses to acute stress in cannabis users.
Acute stress
Alpha-amylase
Cannabis
Cortisol
Distress
Sex differences
Subjective affect
Journal
Psychopharmacology
ISSN: 1432-2072
Titre abrégé: Psychopharmacology (Berl)
Pays: Germany
ID NLM: 7608025
Informations de publication
Date de publication:
Aug 2023
Aug 2023
Historique:
received:
25
02
2023
accepted:
03
06
2023
medline:
17
7
2023
pubmed:
27
6
2023
entrez:
27
6
2023
Statut:
ppublish
Résumé
Cannabis is the most widely used illicit substance in the USA and is often reportedly used for stress reduction. Indeed, cannabinoids modulate signaling of the hypothalamic-pituitary-adrenal axis and sympathetic nervous system. However, the role of biological sex in this interaction between cannabis use and stress is poorly understood, despite sex differences in neurobiological stress responsivity, endocannabinoid signaling, and clinical correlates of cannabis use. The study aims to examine the role of biological sex in multisystem stress responsivity in cannabis users. Frequent cannabis users (> 3 times/week, n = 48, 52% male) and non-users (n = 41, 49% male) participated in an acute psychosocial stress paradigm. Saliva was collected at eight timepoints and analyzed for hypothalamic-pituitary-adrenal (cortisol) and sympathetic (alpha-amylase) indices of stress responsivity, and basal estradiol. Subjective ratings of negative affect, including distress, were collected at three timepoints. Cannabis users showed blunted pre-to-post-stress cortisol reactivity. Female cannabis users demonstrated greater blunted cortisol reactivity than their male counterparts. Sex moderated the effect of cannabis use on alpha-amylase responsivity over time, wherein female cannabis users showed flattened alpha-amylase responses across the stressor compared to male cannabis users and both non-user groups. Qualitatively, female cannabis users demonstrated the greatest pre-to-post-stress change in subjective distress. Differences in stress responding were not explained by estradiol or distress intolerance. Biological sex impacts multisystem stress responding in cannabis users. Paradoxically, female cannabis users showed the least physiological, but greatest subjective, responses to the stressor. Further research into sex differences in the effects of cannabis use is warranted to better understand mechanisms and clinical implications.
Identifiants
pubmed: 37367968
doi: 10.1007/s00213-023-06400-z
pii: 10.1007/s00213-023-06400-z
doi:
Substances chimiques
Hydrocortisone
WI4X0X7BPJ
Hallucinogens
0
alpha-Amylases
EC 3.2.1.1
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1805-1821Subventions
Organisme : NIDA NIH HHS
ID : R01DA048012
Pays : United States
Organisme : NIMH NIH HHS
ID : T32MH103213
Pays : United States
Organisme : NIDA NIH HHS
ID : R01DA048012
Pays : United States
Organisme : NIMH NIH HHS
ID : T32MH103213
Pays : United States
Informations de copyright
© 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
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