Synthetic Site-Specific Antibody-Ligand Conjugates Promote Asialoglycoprotein Receptor-Mediated Degradation of Extracellular Human PCSK9.
Journal
ACS chemical biology
ISSN: 1554-8937
Titre abrégé: ACS Chem Biol
Pays: United States
ID NLM: 101282906
Informations de publication
Date de publication:
21 07 2023
21 07 2023
Historique:
pmc-release:
21
07
2024
medline:
24
7
2023
pubmed:
27
6
2023
entrez:
27
6
2023
Statut:
ppublish
Résumé
Targeted degradation using cell-specific lysosome targeting receptors is emerging as a new therapeutic strategy for the elimination of disease-associated proteins. The liver-specific human asialoglycoprotein receptor (ASGPR) is a particularly attractive lysosome targeting receptor leveraged for targeted protein degradation (TPD). However, the efficiency of different glycan ligands for ASGPR-mediated lysosomal delivery remains to be further characterized. In this study, we applied a chemoenzymatic Fc glycan remodeling method to construct an array of site-specific antibody-ligand conjugates carrying natural bi- and tri-antennary
Identifiants
pubmed: 37368876
doi: 10.1021/acschembio.3c00229
pmc: PMC10530246
mid: NIHMS1916104
doi:
Substances chimiques
Asialoglycoprotein Receptor
0
Ligands
0
Serine Endopeptidases
EC 3.4.21.-
Proprotein Convertases
EC 3.4.21.-
Asialoglycoproteins
0
Cetuximab
PQX0D8J21J
Cholesterol, LDL
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
1611-1623Subventions
Organisme : NIAID NIH HHS
ID : R01 AI155716
Pays : United States
Références
J Mol Biol. 2000 Jul 21;300(4):857-65
pubmed: 10891274
Nat Rev Mol Cell Biol. 2018 Nov;19(11):697-712
pubmed: 30065390
Nat Genet. 2005 Feb;37(2):161-5
pubmed: 15654334
Drug Discov Today Technol. 2019 Apr;31:15-27
pubmed: 31200855
Proc Natl Acad Sci U S A. 2009 Jun 16;106(24):9820-5
pubmed: 19443683
Proc Natl Acad Sci U S A. 2003 Feb 4;100(3):928-33
pubmed: 12552133
Nat Rev Cardiol. 2021 Dec;18(12):805-806
pubmed: 34663945
Methods Cell Biol. 2022;169:1-26
pubmed: 35623698
Int J Biol Sci. 2012;8(3):310-27
pubmed: 22355267
Drug Discov Today Technol. 2019 Apr;31:35-42
pubmed: 31200857
Bioconjug Chem. 2022 Jun 15;33(6):1179-1191
pubmed: 35543724
Nat Rev Mol Cell Biol. 2005 Jan;6(1):79-87
pubmed: 15688069
PLoS One. 2016 Apr 26;11(4):e0154498
pubmed: 27115873
J Biol Chem. 1990 Oct 25;265(30):18429-34
pubmed: 2211711
Biochim Biophys Acta. 2002 Sep 19;1572(2-3):341-63
pubmed: 12223279
ACS Chem Biol. 2021 Nov 19;16(11):2502-2514
pubmed: 34569782
Curr HIV Res. 2013 Jul;11(5):354-64
pubmed: 24191940
Cell Chem Biol. 2021 Jul 15;28(7):1072-1080
pubmed: 33770486
Nucleic Acids Res. 2014 Jul;42(13):8796-807
pubmed: 24992960
PLoS One. 2013 May 07;8(5):e63236
pubmed: 23667591
Chemistry. 2022 Mar 16;28(16):e202200146
pubmed: 35106843
J Lipid Res. 2013 Jun;54(6):1560-1566
pubmed: 23509406
Commun Biol. 2020 Sep 9;3(1):498
pubmed: 32908216
J Biol Chem. 2016 Apr 22;291(17):9356-70
pubmed: 26966183
Anal Biochem. 1974 Sep;61(1):209-24
pubmed: 4472196
Nat Genet. 2003 Jun;34(2):154-6
pubmed: 12730697
Bioconjug Chem. 2017 Feb 15;28(2):283-295
pubmed: 27966887
N Engl J Med. 2006 Mar 23;354(12):1264-72
pubmed: 16554528
Nat Biotechnol. 2005 Oct;23(10):1283-8
pubmed: 16186811
J Biol Chem. 2000 Nov 10;275(45):35176-84
pubmed: 10931846
Hum Mutat. 2009 Apr;30(4):520-9
pubmed: 19191301
Nat Chem Biol. 2021 Sep;17(9):937-946
pubmed: 33767387
N Engl J Med. 2007 Nov 15;357(20):2040-8
pubmed: 18003960
Proc Natl Acad Sci U S A. 2005 Nov 22;102(47):17125-9
pubmed: 16286643
Nat Chem Biol. 2021 Sep;17(9):947-953
pubmed: 34413525
ACS Chem Biol. 2022 May 20;17(5):1259-1268
pubmed: 35481357
J Biol Chem. 1998 Jul 31;273(31):19502-8
pubmed: 9677372
J Am Chem Soc. 2022 Dec 7;144(48):21831-21836
pubmed: 36417563
J Biol Chem. 1999 Dec 10;274(50):35400-6
pubmed: 10585409
J Am Chem Soc. 2021 Jan 20;143(2):593-598
pubmed: 33395526
Cell Chem Biol. 2023 Jan 19;30(1):97-109.e9
pubmed: 36626903
Bioconjug Chem. 2022 Jul 20;33(7):1350-1362
pubmed: 35687881
Proc Natl Acad Sci U S A. 2018 Nov 20;115(47):12023-12027
pubmed: 30397147
J Clin Lipidol. 2019 Nov - Dec;13(6):979-988.e10
pubmed: 31708410
Bioconjug Chem. 2018 Jun 20;29(6):1911-1921
pubmed: 29738673
Proc Natl Acad Sci U S A. 2001 Jul 17;98(15):8554-9
pubmed: 11438690
Annu Rev Biochem. 2018 Jun 20;87:677-696
pubmed: 29648875
Mol Cell. 2019 Dec 5;76(5):797-810.e10
pubmed: 31606272
J Biomol Struct Dyn. 2000 Dec;18(3):435-51
pubmed: 11149519
Clin Pharmacokinet. 2018 Jul;57(7):769-779
pubmed: 29353350
J Biol Chem. 2008 Jan 25;283(4):2363-72
pubmed: 18039658
Curr Opin Lipidol. 2014 Oct;25(5):387-93
pubmed: 25110901
Nature. 2020 Aug;584(7820):291-297
pubmed: 32728216
Chem Soc Rev. 2021 Jan 21;50(2):1305-1353
pubmed: 33290462
MAbs. 2014;6(5):1190-200
pubmed: 25517304
Cell. 2022 Jun 23;185(13):2338-2353.e18
pubmed: 35662409
Bioconjug Chem. 2021 Aug 18;32(8):1888-1897
pubmed: 34351736
ACS Cent Sci. 2021 Mar 24;7(3):499-506
pubmed: 33791431
J Am Coll Cardiol. 2021 Oct 5;78(14):1437-1449
pubmed: 34593126
Trends Biochem Sci. 1991 Oct;16(10):374-7
pubmed: 1785139
ACS Chem Biol. 2022 Nov 18;17(11):3013-3023
pubmed: 35316032