Cortical glutamate and GABA are related to compulsive behaviour in individuals with obsessive compulsive disorder and healthy controls.

Humans Glutamic Acid Obsessive-Compulsive Disorder Proton Magnetic Resonance Spectroscopy Compulsive Behavior gamma-Aminobutyric Acid Magnetic Resonance Imaging

Journal

Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555

Informations de publication

Date de publication:
27 06 2023
Historique:
received: 10 10 2022
accepted: 09 05 2023
medline: 29 6 2023
pubmed: 28 6 2023
entrez: 27 6 2023
Statut: epublish

Résumé

There has been little analysis of neurochemical correlates of compulsive behaviour to illuminate its underlying neural mechanisms. We use 7-Tesla proton magnetic resonance spectroscopy (

Identifiants

DOI: 10.1038/s41467-023-38695-z PMID: 37369695 PMC: PMC10300066
pubmed: 37369695
doi: 10.1038/s41467-023-38695-z
pii: 10.1038/s41467-023-38695-z
pmc: PMC10300066
doi:

Substances chimiques

Glutamic Acid 3KX376GY7L
gamma-Aminobutyric Acid 56-12-2

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

3324

Subventions

Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Department of Health
Pays : United Kingdom

Informations de copyright

© 2023. The Author(s).

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Auteurs

Marjan Biria (M)

Department of Psychology, University of Cambridge, Cambridge, CB2 3EB, UK. mb2184@cam.ac.uk.
Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, CB2 3EB, UK. mb2184@cam.ac.uk.
ORCID: 0000-0003-2671-0150

Paula Banca (P)

Department of Psychology, University of Cambridge, Cambridge, CB2 3EB, UK.
Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, CB2 3EB, UK.
ORCID: 0000-0001-7617-3635

Máiréad P Healy (MP)

Department of Psychology, University of Cambridge, Cambridge, CB2 3EB, UK.
Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, CB2 3EB, UK.
ORCID: 0000-0002-4081-8275

Engin Keser (E)

Department of Psychology, University of Cambridge, Cambridge, CB2 3EB, UK.

Stephen J Sawiak (SJ)

Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, CB2 3EB, UK.
Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, CB2 3EL, UK.
ORCID: 0000-0003-4210-9816

Christopher T Rodgers (CT)

Wolfson Brain Imaging Centre, Department of Clinical Neurosciences, University of Cambridge, Cambridge, CB2 0QQ, UK.
ORCID: 0000-0003-1275-1197

Catarina Rua (C)

Wolfson Brain Imaging Centre, Department of Clinical Neurosciences, University of Cambridge, Cambridge, CB2 0QQ, UK.
Department of Clinical Neurosciences and Cambridge University Hospitals NHS Trust, University of Cambridge, Cambridge, UK.
ORCID: 0000-0002-0404-4399

Ana Maria Frota Lisbôa Pereira de Souza (AMFLP)

Department of Psychology, University of Cambridge, Cambridge, CB2 3EB, UK.
Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, CB2 3EB, UK.
ORCID: 0000-0002-5123-7863

Aleya A Marzuki (AA)

Department of Psychology, University of Cambridge, Cambridge, CB2 3EB, UK.
Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, CB2 3EB, UK.
Department of Psychology, School of Medical and Life Sciences, Sunway University, Petaling Jaya, Malaysia.

Akeem Sule (A)

Department of Psychiatry, School of Clinical Medicine, University of Cambridge, Cambridge, UK.

Karen D Ersche (KD)

Department of Psychiatry, School of Clinical Medicine, University of Cambridge, Cambridge, UK.
Department of Systems Neuroscience, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Department of Addictive Behaviour and Addiction Medicine, Central Institute of Mental Health, University of Heidelberg, Heidelberg, Germany.

Trevor W Robbins (TW)

Department of Psychology, University of Cambridge, Cambridge, CB2 3EB, UK. twr2@cam.ac.uk.
Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, CB2 3EB, UK. twr2@cam.ac.uk.
ORCID: 0000-0003-0642-5977

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Cortical glutamate and GABA are related to...
questionsmedicales.fr › Acides aminés, peptides et protéines › Acides aminés › Acides aminés excitateurs › Acide glutamique › Cortical glutamate and GABA are related to...
questionsmedicales.fr › Troubles mentaux › Troubles anxieux › Trouble obsessionnel compulsif › Cortical glutamate and GABA are related to...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Analyse spectrale › Spectroscopie par résonance magnétique › Spectroscopie par résonance magnétique du proton › Cortical glutamate and GABA are related to...
questionsmedicales.fr › Comportement et mécanismes comportementaux › Comportement › Comportement impulsif › Comportement compulsif › Cortical glutamate and GABA are related to...
questionsmedicales.fr › Acides aminés, peptides et protéines › Acides aminés › Amino-butyrates › Acide gamma-amino-butyrique › Cortical glutamate and GABA are related to...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Imagerie diagnostique › Tomographie › Imagerie par résonance magnétique › Cortical glutamate and GABA are related to...