Therapeutic potential of N-methyl-D-aspartate receptor modulators in psychiatry.
Journal
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
ISSN: 1740-634X
Titre abrégé: Neuropsychopharmacology
Pays: England
ID NLM: 8904907
Informations de publication
Date de publication:
Jan 2024
Jan 2024
Historique:
received:
09
03
2023
accepted:
15
05
2023
revised:
24
04
2023
medline:
11
12
2023
pubmed:
28
6
2023
entrez:
27
6
2023
Statut:
ppublish
Résumé
N-methyl-D-aspartate (NMDA) receptors mediate a slow component of excitatory synaptic transmission, are widely distributed throughout the central nervous system, and regulate synaptic plasticity. NMDA receptor modulators have long been considered as potential treatments for psychiatric disorders including depression and schizophrenia, neurodevelopmental disorders such as Rett Syndrome, and neurodegenerative conditions such as Alzheimer's disease. New interest in NMDA receptors as therapeutic targets has been spurred by the findings that certain inhibitors of NMDA receptors produce surprisingly rapid and robust antidepressant activity by a novel mechanism, the induction of changes in the brain that well outlast the presence of drug in the body. These findings are driving research into an entirely new paradigm for using NMDA receptor antagonists in a host of related conditions. At the same time positive allosteric modulators of NMDA receptors are being pursued for enhancing synaptic function in diseases that feature NMDA receptor hypofunction. While there is great promise, developing the therapeutic potential of NMDA receptor modulators must also navigate the potential significant risks posed by the use of such agents. We review here the emerging pharmacology of agents that target different NMDA receptor subtypes, offering new avenues for capturing the therapeutic potential of targeting this important receptor class.
Identifiants
pubmed: 37369776
doi: 10.1038/s41386-023-01614-3
pii: 10.1038/s41386-023-01614-3
pmc: PMC10700609
doi:
Substances chimiques
Receptors, N-Methyl-D-Aspartate
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
51-66Subventions
Organisme : NIA NIH HHS
ID : R01 AG075444
Pays : United States
Organisme : NICHD NIH HHS
ID : R01 HD082373
Pays : United States
Organisme : NINDS NIH HHS
ID : R35 NS111619
Pays : United States
Informations de copyright
© 2023. The Author(s).
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