Pharmacogenomic Analyses Implicate B Cell Developmental Status and
CD20 (MS4A1)
MKL1 (MRTFA)
TGFB1
obinutuzumab (Gazyva®)
ofatumumab (Arzerra®, Kesimpta®)
rituximab (Rituxan®)
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
07 06 2023
07 06 2023
Historique:
received:
03
04
2023
revised:
02
06
2023
accepted:
04
06
2023
medline:
29
6
2023
pubmed:
28
6
2023
entrez:
28
6
2023
Statut:
epublish
Résumé
Monoclonal antibody (mAb) therapy directed against CD20 is an important tool in the treatment of B cell disorders. However, variable patient response and acquired resistance remain important clinical challenges. To identify genetic factors that may influence sensitivity to treatment, the cytotoxic activity of three CD20 mAbs: rituximab; ofatumumab; and obinutuzumab, were screened in high-throughput assays using 680 ethnically diverse lymphoblastoid cell lines (LCLs) followed by a pharmacogenomic assessment. GWAS analysis identified several novel gene candidates. The most significant SNP, rs58600101, in the gene
Identifiants
pubmed: 37371044
pii: cells12121574
doi: 10.3390/cells12121574
pmc: PMC10297299
pii:
doi:
Substances chimiques
Antibodies, Monoclonal
0
Antigens, CD20
0
Antineoplastic Agents
0
Prednisolone
9PHQ9Y1OLM
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, N.I.H., Intramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIH HHS
ID : 1UM2AI30836-01
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA016086
Pays : United States
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