Genetic Variants of Gonadotropins and Their Receptors Could Influence Controlled Ovarian Stimulation: IVF Data from a Prospective Multicenter Study.
ART
IVF
genetic variants
gonadotropin
ovarian stimulation
polymorphism
Journal
Genes
ISSN: 2073-4425
Titre abrégé: Genes (Basel)
Pays: Switzerland
ID NLM: 101551097
Informations de publication
Date de publication:
15 06 2023
15 06 2023
Historique:
received:
03
03
2023
revised:
19
04
2023
accepted:
22
05
2023
medline:
29
6
2023
pubmed:
28
6
2023
entrez:
28
6
2023
Statut:
epublish
Résumé
Specific polymorphisms might influence controlled ovarian stimulation in women undergoing assisted reproductive technologies (ARTs). Data regarding possible interactions of these polymorphisms are still scanty. The aim of this analysis was to evaluate the effect of polymorphisms of gonadotropins and their receptors in women undergoing ART. A total of 94 normogonadotropic patients from three public ART units were enrolled. Patients underwent a gonadotropin releasing hormone (GnRH) long down-regulation protocol with a starting dose of 150 IU of recombinant follicular stimulating hormone (FSH) daily. Eight polymorphisms were genotyped. A total of 94 women (mean age 30.71 ± 2.61) were recruited. Fewer fertilized and mature oocytes were retrieved in homozygous carriers of luteinizing hormone/choriogonadotropin receptor (LHCGR) 291 (T/T) than in heterozygous C/T carriers ( Our study demonstrated that specific polymorphisms affect the response to ovarian stimulation. Despite this finding, more robust studies are required to establish the clinical utility of genotype analysis before ovarian stimulation.
Sections du résumé
BACKGROUND
Specific polymorphisms might influence controlled ovarian stimulation in women undergoing assisted reproductive technologies (ARTs). Data regarding possible interactions of these polymorphisms are still scanty. The aim of this analysis was to evaluate the effect of polymorphisms of gonadotropins and their receptors in women undergoing ART.
METHODS
A total of 94 normogonadotropic patients from three public ART units were enrolled. Patients underwent a gonadotropin releasing hormone (GnRH) long down-regulation protocol with a starting dose of 150 IU of recombinant follicular stimulating hormone (FSH) daily. Eight polymorphisms were genotyped.
RESULTS
A total of 94 women (mean age 30.71 ± 2.61) were recruited. Fewer fertilized and mature oocytes were retrieved in homozygous carriers of luteinizing hormone/choriogonadotropin receptor (LHCGR) 291 (T/T) than in heterozygous C/T carriers (
CONCLUSIONS
Our study demonstrated that specific polymorphisms affect the response to ovarian stimulation. Despite this finding, more robust studies are required to establish the clinical utility of genotype analysis before ovarian stimulation.
Identifiants
pubmed: 37372449
pii: genes14061269
doi: 10.3390/genes14061269
pmc: PMC10298688
pii:
doi:
Substances chimiques
Gonadotropins
0
Follicle Stimulating Hormone
9002-68-0
Types de publication
Multicenter Study
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Références
Hum Reprod. 2013 May;28(5):1369-74
pubmed: 23504007
PLoS One. 2013 Oct 22;8(10):e78138
pubmed: 24167601
Reprod Sci. 2016 Aug;23(8):1103-8
pubmed: 26902430
Clin Endocrinol (Oxf). 1998 Sep;49(3):369-76
pubmed: 9861329
Clin Endocrinol (Oxf). 2012 Jul;77(1):113-9
pubmed: 22356187
Reprod Biomed Online. 2016 Sep;33(3):391-7
pubmed: 27448492
J Clin Endocrinol Metab. 1995 Apr;80(4):1257-63
pubmed: 7714098
Mol Cell Endocrinol. 2014 Aug 5;393(1-2):83-91
pubmed: 24970684
Reproduction. 2015 Dec;150(6):R175-84
pubmed: 26370242
Fertil Steril. 2013 Jan;99(1):149-155
pubmed: 22985950
Best Pract Res Clin Obstet Gynaecol. 2022 Dec;85(Pt B):159-187
pubmed: 35725717
Front Endocrinol (Lausanne). 2021 Mar 19;12:587051
pubmed: 33815269
Bioinformatics. 2006 Aug 1;22(15):1928-9
pubmed: 16720584
Hum Reprod Update. 2018 Sep 1;24(5):599-614
pubmed: 29924306
J Clin Endocrinol Metab. 2000 Sep;85(9):3365-9
pubmed: 10999835
Reprod Biomed Online. 2011 Feb;22 Suppl 1:S67-72
pubmed: 21575852
J Clin Endocrinol Metab. 2011 Sep;96(9):2805-12
pubmed: 21752882
Mol Hum Reprod. 2002 Oct;8(10):893-9
pubmed: 12356937
Pharmacogenet Genomics. 2005 Jul;15(7):451-6
pubmed: 15970792
Front Endocrinol (Lausanne). 2022 Feb 01;12:797365
pubmed: 35178027
Clin Endocrinol (Oxf). 2015 Apr;82(4):577-83
pubmed: 25132286
Hum Reprod. 2021 May 17;36(6):1711-1721
pubmed: 33889959
J Ovarian Res. 2014 Jun 18;7:67
pubmed: 24991235
Reprod Biomed Online. 2013 Oct;27(4):400-6
pubmed: 23953588
Hum Reprod. 2016 Mar;31(3):672-83
pubmed: 26769719
Hum Reprod Update. 2011 Nov-Dec;17(6):813-28
pubmed: 21862569
Reprod Biomed Online. 2009 Apr;18(4):509-15
pubmed: 19400992
Reprod Biol Endocrinol. 2013 Jun 01;11:51
pubmed: 23725475
J Assist Reprod Genet. 2012 Jul;29(7):657-63
pubmed: 22527896