Meta-CF
GFP
Kaede
endoplasmic reticulum
fluorescence
fluorogen
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
08 Jun 2023
08 Jun 2023
Historique:
received:
18
05
2023
revised:
05
06
2023
accepted:
07
06
2023
medline:
29
6
2023
pubmed:
28
6
2023
entrez:
28
6
2023
Statut:
epublish
Résumé
In this work, we have shown that the introduction of a trifluoromethyl group into the me-ta-position of arylidene imidazolones (GFP chromophore core) leads to a dramatic increase in their fluorescence in nonpolar and aprotic media. The presence of a pronounced solvent-dependent gradation of fluorescence intensity makes it possible to use these substances as fluorescent polarity sensors. In particular, we showed that one of the created compounds could be used for selective labeling of the endoplasmic reticulum of living cells.
Identifiants
pubmed: 37373071
pii: ijms24129923
doi: 10.3390/ijms24129923
pmc: PMC10298595
pii:
doi:
Substances chimiques
Green Fluorescent Proteins
147336-22-9
Solvents
0
Coloring Agents
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Ministry of Science and Higher Education of the Russian Federation
ID : agreement No. 075-15-2020-773, internal No. 13.1902.21.0041
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
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