Antiangiogenic Effect of Dopamine and Dopaminergic Agonists as an Adjuvant Therapeutic Option in the Treatment of Cancer, Endometriosis, and Osteoarthritis.
Female
Humans
Dopamine Agonists
/ pharmacology
Dopamine
/ metabolism
Vascular Endothelial Growth Factor Receptor-2
/ metabolism
Endometriosis
/ drug therapy
Vascular Endothelial Growth Factor A
/ metabolism
Angiogenesis Inhibitors
/ pharmacology
Neoplasms
/ metabolism
Adjuvants, Immunologic
/ therapeutic use
Osteoarthritis
/ drug therapy
Neovascularization, Pathologic
/ drug therapy
antiangiogenic
cancer
dopamine (DA)
dopamine agonists (DA-Ag)
endometriosis
osteoarthritis (OA)
vascular endothelial growth factor (VEGF)
vascular endothelial growth factor receptor (VEGFR)
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
15 Jun 2023
15 Jun 2023
Historique:
received:
27
05
2023
revised:
12
06
2023
accepted:
13
06
2023
medline:
29
6
2023
pubmed:
28
6
2023
entrez:
28
6
2023
Statut:
epublish
Résumé
Dopamine (DA) and dopamine agonists (DA-Ag) have shown antiangiogenic potential through the vascular endothelial growth factor (VEGF) pathway. They inhibit VEGF and VEGF receptor 2 (VEGFR 2) functions through the dopamine receptor D2 (D2R), preventing important angiogenesis-related processes such as proliferation, migration, and vascular permeability. However, few studies have demonstrated the antiangiogenic mechanism and efficacy of DA and DA-Ag in diseases such as cancer, endometriosis, and osteoarthritis (OA). Therefore, the objective of this review was to describe the mechanisms of the antiangiogenic action of the DA-D2R/VEGF-VEGFR 2 system and to compile related findings from experimental studies and clinical trials on cancer, endometriosis, and OA. Advanced searches were performed in PubMed, Web of Science, SciFinder, ProQuest, EBSCO, Scopus, Science Direct, Google Scholar, PubChem, NCBI Bookshelf, DrugBank, livertox, and Clinical Trials. Articles explaining the antiangiogenic effect of DA and DA-Ag in research articles, meta-analyses, books, reviews, databases, and clinical trials were considered. DA and DA-Ag have an antiangiogenic effect that could reinforce the treatment of diseases that do not yet have a fully curative treatment, such as cancer, endometriosis, and OA. In addition, DA and DA-Ag could present advantages over other angiogenic inhibitors, such as monoclonal antibodies.
Identifiants
pubmed: 37373348
pii: ijms241210199
doi: 10.3390/ijms241210199
pmc: PMC10299003
pii:
doi:
Substances chimiques
Dopamine Agonists
0
Dopamine
VTD58H1Z2X
Vascular Endothelial Growth Factor Receptor-2
EC 2.7.10.1
Vascular Endothelial Growth Factor A
0
Angiogenesis Inhibitors
0
Adjuvants, Immunologic
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
Références
Nat Med. 1995 Nov;1(11):1184-8
pubmed: 7584992
Int J Mol Sci. 2021 Apr 05;22(7):
pubmed: 33916438
EMBO J. 1993 Apr;12(4):1693-703
pubmed: 8385611
Calcif Tissue Int. 2014 Dec;95(6):495-505
pubmed: 25311420
Arthritis Rheum. 2003 Aug;48(8):2173-7
pubmed: 12905470
Int J Mol Sci. 2019 Jan 29;20(3):
pubmed: 30699963
J Neuroimmune Pharmacol. 2013 Mar;8(1):7-14
pubmed: 22886869
Cell. 2019 Mar 7;176(6):1248-1264
pubmed: 30849371
BMC Musculoskelet Disord. 2018 Jun 26;19(1):204
pubmed: 29945585
Psychopharmacology (Berl). 2009 Mar;202(4):611-20
pubmed: 18836703
Int J Cancer. 2017 May 1;140(9):2150-2161
pubmed: 28152577
Proc Natl Acad Sci U S A. 2005 Jan 25;102(4):1076-81
pubmed: 15644447
Acta Neurol Belg. 2017 Sep;117(3):613-621
pubmed: 27995487
Oncol Res Treat. 2018;41(4):166-171
pubmed: 29562226
Gynecol Obstet Invest. 2017;82(6):527-532
pubmed: 27883998
J Immunol. 2009 Jun 15;182(12):7937-45
pubmed: 19494318
Int J Mol Sci. 2014 Apr 28;15(5):7250-65
pubmed: 24786088
Proc Natl Acad Sci U S A. 1972 Aug;69(8):2145-9
pubmed: 4403305
Annu Rev Neurosci. 2011;34:441-66
pubmed: 21469956
Mov Disord. 2021 Sep;36(9):2136-2143
pubmed: 33960511
J Neurosci. 2006 Jul 19;26(29):7723-9
pubmed: 16855100
Stem Cells Int. 2022 Jun 29;2022:4154440
pubmed: 35813889
Cancer Immunol Immunother. 2021 Aug;70(8):2165-2177
pubmed: 33454798
Neuroendocrinology. 2019;109(1):34-41
pubmed: 30852578
Arch Gynecol Obstet. 2015 May;291(5):1103-11
pubmed: 25367601
Urol Oncol. 2012 Nov-Dec;30(6):848-55
pubmed: 20926319
Histochem Cell Biol. 2003 Sep;120(3):235-41
pubmed: 12904969
Semin Cell Dev Biol. 2017 Feb;62:50-56
pubmed: 27771363
Br J Pharmacol. 2015 Jan;172(1):1-23
pubmed: 25671228
Cell Commun Signal. 2022 Apr 7;20(1):49
pubmed: 35392964
Neuron. 1995 Jul;15(1):35-44
pubmed: 7619528
Cells. 2022 May 11;11(10):
pubmed: 35626646
EMBO J. 1996 Jan 15;15(2):290-98
pubmed: 8617204
Expert Opin Pharmacother. 2000 Mar;1(3):555-74
pubmed: 11249538
Exp Cell Res. 2002 Jan 1;272(1):32-44
pubmed: 11740863
Connect Tissue Res. 2014 Aug;55(4):257-61
pubmed: 24844414
Cells. 2022 Apr 02;11(7):
pubmed: 35406766
J Biomed Sci. 2020 Jan 2;27(1):1
pubmed: 31894001
MAbs. 2010 Mar-Apr;2(2):165-75
pubmed: 20190566
Bone Res. 2015 Jul 07;3:15020
pubmed: 26558139
Reprod Toxicol. 1996 Jul-Aug;10(4):333-7
pubmed: 8829257
Osteoarthritis Cartilage. 2016 Feb;24(2):325-34
pubmed: 26327449
BMC Neurol. 2022 Aug 25;22(1):320
pubmed: 36008796
Arch Gynecol Obstet. 2014 Oct;290(4):677-82
pubmed: 24748338
Neurosignals. 2009;17(1):5-22
pubmed: 18948702
Int J Mol Sci. 2019 Jun 26;20(13):
pubmed: 31248037
ACS Appl Mater Interfaces. 2020 Nov 18;12(46):51236-51248
pubmed: 33166449
Arthritis Rheum. 2009 Dec;60(12):3723-33
pubmed: 19950295
Curr Opin Rheumatol. 2008 Sep;20(5):573-80
pubmed: 18698180
J Pharmacol Exp Ther. 2018 Sep;366(3):519-526
pubmed: 29921706
ACS Chem Neurosci. 2015 Apr 15;6(4):681-92
pubmed: 25660762
Fertil Steril. 2011 Mar 1;95(3):882-8.e1
pubmed: 21055747
Hum Reprod Update. 2012 Nov-Dec;18(6):682-702
pubmed: 22718320
J Neurosci. 2002 May 1;22(9):3708-19
pubmed: 11978847
Cells. 2020 May 25;9(5):
pubmed: 32466159
Chem Commun (Camb). 2019 Dec 28;55(100):15057-15060
pubmed: 31777882
J Clin Invest. 2008 Apr;118(4):1380-9
pubmed: 18340382
J Cell Sci. 2022 Jun 1;135(11):
pubmed: 35593650
J Nutr. 2007 Jun;137(6 Suppl 1):1539S-1547S; discussion 1548S
pubmed: 17513421
Hum Reprod. 2021 Mar 18;36(4):850-858
pubmed: 33355352
Acta Obstet Gynecol Scand. 2019 Oct;98(10):1341-1350
pubmed: 31025313
PLoS One. 2016 Dec 21;11(12):e0167971
pubmed: 28002442
Obstet Gynecol Surv. 2021 May;76(5):281-291
pubmed: 34032860
Front Glob Womens Health. 2022 Apr 05;3:856316
pubmed: 35449709
J Hematol Oncol. 2016 Oct 18;9(1):111
pubmed: 27756337
Osteoarthritis Cartilage. 2001;9 Suppl A:S91-101
pubmed: 11680695
Nanoscale. 2019 Jun 20;11(24):11605-11616
pubmed: 31173033
Osteoarthritis Cartilage. 2000 May;8(3):213-21
pubmed: 10806049
Rom J Morphol Embryol. 2018;59(2):455-467
pubmed: 30173249
Curr Med Res Opin. 2009 Aug;25(8):2081-90
pubmed: 19586325
Pituitary. 2001 Aug;4(3):179-85
pubmed: 12138991
Breast Cancer Res Treat. 2017 Oct;165(3):585-592
pubmed: 28674764
Neuron. 2008 Nov 26;60(4):543-54
pubmed: 19038213
Pharmacol Rev. 2011 Mar;63(1):182-217
pubmed: 21303898
Cell Tissue Res. 2014 Dec;358(3):651-65
pubmed: 25173883
Neuropsychiatr Dis Treat. 2009;5:33-6
pubmed: 19557097
Arch Biochem Biophys. 2011 Apr 1;508(1):1-12
pubmed: 21176768
Tidsskr Nor Laegeforen. 2010 Nov 4;130(21):2136-40
pubmed: 21052117
Nat Rev Rheumatol. 2010 Feb;6(2):61
pubmed: 20976859
Drugs. 2004;64(18):2125-41
pubmed: 15341508
Arthritis Res Ther. 2006;8(1):104
pubmed: 16542470
J Pharmacol Exp Ther. 2019 Jul;370(1):111-126
pubmed: 31000578
Int J Mol Sci. 2021 Sep 29;22(19):
pubmed: 34638893
Gen Pharmacol. 1999 Mar;32(3):373-9
pubmed: 10211594
Cochrane Database Syst Rev. 2016 Nov 30;11:CD008605
pubmed: 27901279
Arthritis Res Ther. 2014 Sep 18;16(5):427
pubmed: 25230745
J Biol Chem. 2001 Aug 31;276(35):32714-9
pubmed: 11435426
Nat Rev Rheumatol. 2011 Sep 27;7(11):654-63
pubmed: 21947178
Biol Reprod. 2010 Nov;83(5):866-73
pubmed: 20574053
Biomedicines. 2021 Mar 08;9(3):
pubmed: 33800198
J Clin Med. 2021 Jun 26;10(13):
pubmed: 34206900
Int J Mol Sci. 2017 Aug 17;18(8):
pubmed: 28817103
CNS Drug Rev. 2004 Fall;10(3):230-42
pubmed: 15492773
Endocr Relat Cancer. 2011 Dec 01;18(6):R233-51
pubmed: 22135243
Cell Death Dis. 2017 Mar 30;8(3):e2715
pubmed: 28358372
Handb Exp Pharmacol. 2012;(212):53-86
pubmed: 23129328
CNS Drugs. 2019 Sep;33(9):905-918
pubmed: 31473980
Transl Psychiatry. 2021 Feb 16;11(1):59
pubmed: 33589583
Proc Natl Acad Sci U S A. 2006 Dec 12;103(50):19004-9
pubmed: 17142326
Transl Oncol. 2019 Jul;12(7):981-986
pubmed: 31121490
Foods. 2022 Feb 11;11(4):
pubmed: 35206003
Biomaterials. 2021 Nov;278:121169
pubmed: 34626937
Am J Physiol Heart Circ Physiol. 2004 Oct;287(4):H1554-60
pubmed: 15371263
Pharmacol Ther. 2019 Nov;203:107392
pubmed: 31299315
J Leukoc Biol. 2017 Feb;101(2):357-365
pubmed: 27733575
Proc Natl Acad Sci U S A. 1991 Oct 15;88(20):9267-71
pubmed: 1924389
Clin Cancer Res. 2011 Jun 1;17(11):3649-59
pubmed: 21531818
Cell Mol Life Sci. 2022 Jan 14;79(1):71
pubmed: 35029764
Int J Cancer. 2015 Aug 1;137(3):744-9
pubmed: 25556636
Addict Biol. 2018 Mar;23(2):569-584
pubmed: 28436559
Mov Disord. 2003 Aug;18(8):898-905
pubmed: 12889079
Cancer J. 2008 May-Jun;14(3):170-7
pubmed: 18536556
Cell Mol Life Sci. 2020 May;77(9):1745-1770
pubmed: 31690961
Biomed Pharmacother. 2019 Nov;119:109419
pubmed: 31563117
J Biol Chem. 2017 Jan 13;292(2):435-445
pubmed: 27920206
J Cell Sci. 2009 Sep 15;122(Pt 18):3385-92
pubmed: 19706677
Sci Rep. 2021 Jan 13;11(1):853
pubmed: 33441630
FASEB J. 2004 Jul;18(10):1111-3
pubmed: 15132990
Hum Reprod. 2009 May;24(5):1025-35
pubmed: 19189995
Bioorg Chem. 2023 Apr;133:106425
pubmed: 36801788
Hum Reprod Update. 2018 Mar 01;24(2):207-224
pubmed: 29377994
Nature. 1988 Dec 22-29;336(6201):783-7
pubmed: 2974511
J Cell Physiol. 2017 Nov;232(11):3103-3111
pubmed: 28019670
Cell Commun Signal. 2013 May 17;11(1):34
pubmed: 23683503
Endocrinology. 2006 Nov;147(11):5400-11
pubmed: 16901966
Gynecol Endocrinol. 2020;36(sup1):7-11
pubmed: 33305662
Front Cell Neurosci. 2017 Feb 08;11:27
pubmed: 28228718
Cell Mol Neurobiol. 2019 Jan;39(1):31-59
pubmed: 30446950
Osteoarthritis Cartilage. 2015 Nov;23(11):1890-6
pubmed: 26521734
Nat Med. 2001 May;7(5):569-74
pubmed: 11329058
Rev Bras Reumatol Engl Ed. 2017 Mar - Apr;57(2):162-173
pubmed: 28343622
J Clin Endocrinol Metab. 1986 Oct;63(4):941-5
pubmed: 3745407
Reproduction. 2011 Nov;142(5):745-55
pubmed: 21862695
Pharmacol Ther. 2016 Aug;164:204-25
pubmed: 27288725
Sci Rep. 2020 Jul 17;10(1):11928
pubmed: 32681006
Behav Pharmacol. 2018 Apr;29(2 and 3-Spec Issue):225-233
pubmed: 29035918
Clin Cancer Res. 2004 Jul 1;10(13):4349-56
pubmed: 15240521
Rheumatology (Oxford). 2005 Jan;44(1):7-16
pubmed: 15292527
Oncology. 2005;69 Suppl 3:4-10
pubmed: 16301830
Int J Mol Sci. 2019 Mar 11;20(5):
pubmed: 30861996
Fertil Steril. 2012 Sep;98(3):529-55
pubmed: 22938768
Mol Brain. 2011 Jun 13;4:26
pubmed: 21663703
Biochem Biophys Res Commun. 2007 Mar 23;354(4):975-80
pubmed: 17276390
J Exp Clin Cancer Res. 2019 Jun 11;38(1):250
pubmed: 31186061
J Invest Surg. 2021 Aug;34(8):897-901
pubmed: 31906754
Proc Natl Acad Sci U S A. 1998 Jan 20;95(2):548-53
pubmed: 9435229
Physiol Rev. 1998 Jan;78(1):189-225
pubmed: 9457173
Adv Healthc Mater. 2019 Sep;8(18):e1900283
pubmed: 31379139
J Clin Endocrinol Metab. 1997 Mar;82(3):876-83
pubmed: 9062500
J Cell Biol. 2000 Nov 13;151(4):879-89
pubmed: 11076971
BioDrugs. 2009;23(5):289-304
pubmed: 19754219
Cancer Res. 2009 May 1;69(9):3727-30
pubmed: 19383906
Open Med (Wars). 2018 Jul 10;13:270-277
pubmed: 30019007
Arthritis Rheum. 2004 Mar;50(3):828-39
pubmed: 15022325
Cancer Microenviron. 2018 Jun;11(1):1-11
pubmed: 29502307
J Colloid Interface Sci. 2022 Aug;619:207-218
pubmed: 35397456
Eur J Pharmacol. 2021 Feb 5;892:173760
pubmed: 33279520
Ageing Res Rev. 2023 Jun;87:101907
pubmed: 36893920
Front Cell Dev Biol. 2020 Nov 16;8:599281
pubmed: 33304904
Proc Natl Acad Sci U S A. 1996 Mar 19;93(6):2576-81
pubmed: 8637916
J Biochem Mol Biol. 2006 Sep 30;39(5):469-78
pubmed: 17002866
Development. 2007 Nov;134(21):3917-28
pubmed: 17913788
Arthritis Rheumatol. 2015 Jul;67(7):1826-36
pubmed: 25776267
Drug Saf. 1996 Apr;14(4):228-38
pubmed: 8713691
Taiwan J Obstet Gynecol. 2018 Dec;57(6):830-835
pubmed: 30545536
Eur J Pharmacol. 2021 Dec 5;912:174517
pubmed: 34555394
Arthritis Rheum. 2004 Jan;50(1):131-41
pubmed: 14730609
J Cancer. 2019 Mar 3;10(7):1622-1632
pubmed: 31205518
Biomedicines. 2020 Dec 16;8(12):
pubmed: 33339236
Int J Biol Macromol. 2022 Apr 1;203:492-504
pubmed: 35101479
Bone. 2017 Oct;103:168-176
pubmed: 28689816
Nat Rev Rheumatol. 2011 Jan;7(1):33-42
pubmed: 21119608
Nat Neurosci. 2007 Mar;10(3):376-84
pubmed: 17277774
Ann Neurosci. 2016 Jul;23(2):89-99
pubmed: 27647959
Nat Rev Dis Primers. 2016 Oct 13;2:16072
pubmed: 27734845
Clin Cancer Res. 2008 Apr 15;14(8):2502-10
pubmed: 18413843
Pharmaceutics. 2023 Feb 18;15(2):
pubmed: 36840015
Mol Oncol. 2015 Jan;9(1):270-81
pubmed: 25226814
Int J Mol Sci. 2017 Apr 28;18(5):
pubmed: 28452955
Bone. 2001 Jan;28(1):65-71
pubmed: 11165944
Int J Mol Sci. 2022 Feb 04;23(3):
pubmed: 35163699