Translation termination in human mitochondria - substrate specificity of mitochondrial release factors.
COX1 translation
mitoribosome rescue
mitoribosome-associated quality control
mtRF1
mtRF1a
non-canonical stop codons
Journal
Biological chemistry
ISSN: 1437-4315
Titre abrégé: Biol Chem
Pays: Germany
ID NLM: 9700112
Informations de publication
Date de publication:
26 07 2023
26 07 2023
Historique:
received:
08
02
2023
accepted:
19
06
2023
medline:
8
9
2023
pubmed:
28
6
2023
entrez:
28
6
2023
Statut:
epublish
Résumé
Mitochondria are the essential players in eukaryotic ATP production by oxidative phosphorylation, which relies on the maintenance and accurate expression of the mitochondrial genome. Even though the basic principles of translation are conserved due to the descendance from a bacterial ancestor, some deviations regarding translation factors as well as mRNA characteristics and the applied genetic code are present in human mitochondria. Together, these features are certain challenges during translation the mitochondrion has to handle. Here, we discuss the current knowledge regarding mitochondrial translation focusing on the termination process and the associated quality control mechanisms. We describe how mtRF1a resembles bacterial RF1 mechanistically and summarize
Identifiants
pubmed: 37377370
pii: hsz-2023-0127
doi: 10.1515/hsz-2023-0127
doi:
Substances chimiques
Codon, Terminator
0
Peptide Termination Factors
0
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
769-779Informations de copyright
© 2023 the author(s), published by De Gruyter, Berlin/Boston.
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