Comparison of Short-Course and Conventional Antimicrobial Duration in Mild and Moderate Complicated Intra-Abdominal Infections: A randomised controlled trial.
Abdominal Abscess
Antibiotic Prophylaxis
Antimicrobial Stewardship
Appendicitis
Drug Resistance
India
Intra-Abdominal Infection
Microbial
Perforated
Peritonitis
Surgical Wound Infection
Journal
Sultan Qaboos University medical journal
ISSN: 2075-0528
Titre abrégé: Sultan Qaboos Univ Med J
Pays: Oman
ID NLM: 101519915
Informations de publication
Date de publication:
May 2023
May 2023
Historique:
received:
01
02
2022
revised:
10
06
2022
revised:
17
08
2022
accepted:
27
08
2022
medline:
30
6
2023
pubmed:
28
6
2023
entrez:
28
6
2023
Statut:
ppublish
Résumé
Studies have shown the feasibility of short-course antimicrobials in complicated intra-abdominal infection (CIAI) following source control procedure (SCP). This study aimed to compare postoperative complication rates in short-course (5 days) and conventional (7-10 days) duration groups after antimicrobial therapy. This was a single-centre, open-labelled, randomised controlled trial conducted in Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry, India, from July 2017 to December 2019 on patients with CIAI. Patients who were haemodynamically unstable, pregnant and had non-perforated, non-gangrenous appendicitis or cholecystitis were excluded. Primary endpoints were surgical site infection (SSI), recurrent intra-abdominal infection (IAI) and mortality. Secondary endpoints included time till occurrence of composite primary outcomes, duration of antimicrobial therapy, the length of hospital stays, antimicrobial-free interval, hospital-free days at 30 day intervals and the presence of extra-abdominal infections. Overall, 140 patients were included whose demographic and clinico-pathological details were comparable in both groups. There was no difference in SSI (37% versus 35.6%) and recurrent IAI (5.7% versus 2.8%; Short-course antimicrobial therapy for 5 days following SCP for mild and moderate CIAI was comparable to conventional duration antimicrobial therapy, indicating similar efficacy.
Identifiants
pubmed: 37377823
doi: 10.18295/squmj.1.2023.006
pii: squmj2305-212-219
pmc: PMC10292598
doi:
Substances chimiques
Anti-Infective Agents
0
Types de publication
Randomized Controlled Trial
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
212-219Informations de copyright
© Copyright 2023, Sultan Qaboos University Medical Journal, All Rights Reserved.
Déclaration de conflit d'intérêts
CONFLICT OF INTEREST The authors declare no conflict of interest.
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