Bumetanide Attenuates Cognitive Deficits and Brain Damage in Rats Subjected to Hypoxia-Ischemia at Two Time Points of the Early Postnatal Period.
Bumetanide
KCC2
NKCC1
Neonatal hypoxia–ischemia
Neurodevelopment
Synaptogenesis
Journal
Neurotoxicity research
ISSN: 1476-3524
Titre abrégé: Neurotox Res
Pays: United States
ID NLM: 100929017
Informations de publication
Date de publication:
Dec 2023
Dec 2023
Historique:
received:
09
11
2022
accepted:
16
06
2023
revised:
24
05
2023
medline:
29
11
2023
pubmed:
28
6
2023
entrez:
28
6
2023
Statut:
ppublish
Résumé
Neonatal hypoxia-ischemia (HI) is one of the main causes of tissue damage, cell death, and imbalance between neuronal excitation and inhibition and synaptic loss in newborns. GABA, the major inhibitory neurotransmitter of the central nervous system (CNS) in adults, is excitatory at the onset of neurodevelopment and its action depends on the chloride (Cl
Identifiants
pubmed: 37378827
doi: 10.1007/s12640-023-00654-3
pii: 10.1007/s12640-023-00654-3
doi:
Substances chimiques
Bumetanide
0Y2S3XUQ5H
Solute Carrier Family 12, Member 2
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
526-545Informations de copyright
© 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
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