Acute stress induces long-term metabolic, functional, and structural remodeling of the heart.
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
28 06 2023
28 06 2023
Historique:
received:
17
05
2022
accepted:
21
06
2023
medline:
30
6
2023
pubmed:
29
6
2023
entrez:
28
6
2023
Statut:
epublish
Résumé
Takotsubo cardiomyopathy is a stress-induced cardiovascular disease with symptoms comparable to those of an acute coronary syndrome but without coronary obstruction. Takotsubo was initially considered spontaneously reversible, but epidemiological studies revealed significant long-term morbidity and mortality, the reason for which is unknown. Here, we show in a female rodent model that a single pharmacological challenge creates a stress-induced cardiomyopathy similar to Takotsubo. The acute response involves changes in blood and tissue biomarkers and in cardiac in vivo imaging acquired with ultrasound, magnetic resonance and positron emission tomography. Longitudinal follow up using in vivo imaging, histochemistry, protein and proteomics analyses evidences a continued metabolic reprogramming of the heart towards metabolic malfunction, eventually leading to irreversible damage in cardiac function and structure. The results combat the supposed reversibility of Takotsubo, point to dysregulation of glucose metabolic pathways as a main cause of long-term cardiac disease and support early therapeutic management of Takotsubo.
Identifiants
pubmed: 37380648
doi: 10.1038/s41467-023-39590-3
pii: 10.1038/s41467-023-39590-3
pmc: PMC10307856
doi:
Substances chimiques
Glucose-6-Phosphate
56-73-5
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
3835Subventions
Organisme : Marie Curie
ID : 101030046
Pays : United Kingdom
Commentaires et corrections
Type : ErratumIn
Informations de copyright
© 2023. The Author(s).
Références
ESC Heart Fail. 2021 Oct;8(5):4130-4138
pubmed: 34463049
Mol Imaging Biol. 2020 Oct;22(5):1342-1352
pubmed: 32602084
J Invasive Cardiol. 2008 Nov;20(11):E310-3
pubmed: 18987407
Cardiovasc Revasc Med. 2019 Jan;20(1):70-79
pubmed: 30528096
Expert Rev Cardiovasc Ther. 2011 Sep;9(9):1093-6
pubmed: 21932950
Eur J Heart Fail. 2013 Jan;15(1):9-22
pubmed: 23099354
J Biol Chem. 2003 Nov 7;278(45):44230-7
pubmed: 12941958
Cardiovasc Res. 2022 Jun 29;118(8):1932-1946
pubmed: 33711093
Cardiovasc Res. 2007 Jan 15;73(2):288-97
pubmed: 16970929
Eur Heart J. 2018 Jun 7;39(22):2032-2046
pubmed: 29850871
J Am Coll Cardiol. 2005 Jan 4;45(1):87-92
pubmed: 15629380
Circulation. 2018 Mar 6;137(10):1039-1048
pubmed: 29128863
Proc Natl Acad Sci U S A. 2020 Jun 23;117(25):14259-14269
pubmed: 32513743
Diabetes Care. 2014 Aug;37(8):2268-75
pubmed: 25061139
Diabetes. 1984 Feb;33(2):196-9
pubmed: 6692996
J Am Heart Assoc. 2014 Jun 23;3(3):e000921
pubmed: 24958782
Diabetes. 2000 Dec;49(12):2070-8
pubmed: 11118009
PeerJ. 2021 Mar 12;9:e11085
pubmed: 33763310
J Clin Invest. 1998 Jan 1;101(1):160-9
pubmed: 9421478
Circ Res. 2008 Dec 5;103(12):1354-8
pubmed: 18988896
J Am Coll Cardiol. 2018 Aug 21;72(8):874-882
pubmed: 30115226
iScience. 2021 Nov 26;24(12):103517
pubmed: 34934932
Am J Physiol Cell Physiol. 2007 Apr;292(4):C1370-8
pubmed: 17135297
JCI Insight. 2022 Feb 8;7(3):
pubmed: 35132957
N Engl J Med. 2005 Feb 10;352(6):539-48
pubmed: 15703419
Pharmacol Res. 2017 Feb;116:45-56
pubmed: 27988387
Int J Mol Sci. 2022 Apr 25;23(9):
pubmed: 35563125
Stress. 2009 Jan;12(1):1-21
pubmed: 19116888
Mol Cell. 2017 Nov 2;68(3):591-604.e5
pubmed: 29100056
Eur J Heart Fail. 2016 Jan;18(1):8-27
pubmed: 26548803
Genes Dev. 2019 Nov 1;33(21-22):1491-1505
pubmed: 31558567
Theranostics. 2017 Jul 8;7(11):2757-2774
pubmed: 28824714
Int J Cardiol. 2013 Oct 3;168(3):1943-50
pubmed: 23357048
J Cardiovasc Magn Reson. 2017 Feb 6;19(1):15
pubmed: 28162089
Biochim Biophys Acta. 2016 Dec;1862(12):2232-2243
pubmed: 27544701
Ann Neurol. 1979 Nov;6(5):371-88
pubmed: 117743
J Diabetes Complications. 2002 Jan-Feb;16(1):72-80
pubmed: 11872372
Am J Physiol Endocrinol Metab. 2008 Jul;295(1):E17-28
pubmed: 18445751
Comput Biol Med. 2018 Jan 1;92:197-203
pubmed: 29227821
J Immunol. 2020 Nov 1;205(9):2499-2510
pubmed: 32978282
Theranostics. 2021 Feb 6;11(8):3830-3838
pubmed: 33664864
J Mol Cell Cardiol. 2010 Jun;48(6):1088-95
pubmed: 20184889
Crit Care Med. 2007 Sep;35(9 Suppl):S508-18
pubmed: 17713401
Annu Rev Nutr. 1992;12:327-43
pubmed: 1503809
J Biol Chem. 2007 Dec 28;282(52):37501-7
pubmed: 17971451
N Engl J Med. 2015 Sep 3;373(10):929-38
pubmed: 26332547
Diabetes. 2015 Oct;64(10):3573-87
pubmed: 26109417
J Echocardiogr. 2020 Dec;18(4):199-224
pubmed: 32886290
Physiol Rev. 2005 Jul;85(3):1093-129
pubmed: 15987803
BMC Biol. 2019 Jul 4;17(1):52
pubmed: 31272438
Nat Rev Endocrinol. 2017 Sep;13(9):547-560
pubmed: 28664919
Physiol Genomics. 2012 Feb 1;44(2):162-72
pubmed: 22128088
Nat Protoc. 2007;2(8):1896-906
pubmed: 17703201
Molecules. 2018 Nov 02;23(11):
pubmed: 30400201
Oxid Med Cell Longev. 2017;2017:1308692
pubmed: 29456783
J Am Coll Cardiol. 2000 Oct;36(4):1233-8
pubmed: 11028476
Circulation. 2012 Aug 7;126(6):697-706
pubmed: 22732314
Am J Pathol. 2022 May;192(5):783-793
pubmed: 35183511
Arq Bras Cardiol. 2013 Jul;101(1):52-8
pubmed: 23702813
Eur Heart J. 2007 Oct;28(20):2456-64
pubmed: 17395683
Exp Diabetes Res. 2007;2007:61038
pubmed: 18224243
Endocr Rev. 2005 May;26(3):380-92
pubmed: 15814847
JACC Cardiovasc Imaging. 2019 Sep;12(9):1849-1863
pubmed: 31488253
Nat Rev Mol Cell Biol. 2017 Jul;18(7):452-465
pubmed: 28488703
J Am Soc Hypertens. 2009 Nov-Dec;3(6):374-87
pubmed: 20409980
Front Pharmacol. 2012 May 09;3:87
pubmed: 22582044
Circulation. 2022 Dec 13;146(24):1823-1835
pubmed: 36317524
Eur Heart J. 2006 Jul;27(13):1523-9
pubmed: 16720686
Am Heart J. 2008 Mar;155(3):408-17
pubmed: 18294473
Ann Endocrinol (Paris). 2021 Jun;82(3-4):193-197
pubmed: 32473788
Nature. 2008 Feb 21;451(7181):964-9
pubmed: 18288188
Nucleic Acids Res. 2022 Jan 7;50(D1):D543-D552
pubmed: 34723319
J Clin Invest. 1996 Aug 15;98(4):930-6
pubmed: 8770864
Radiology. 2018 Jan;286(1):83-92
pubmed: 28813234
Biochem Biophys Res Commun. 2021 Dec 17;583:121-127
pubmed: 34735873
J Biol Chem. 2007 Apr 13;282(15):11397-409
pubmed: 17237229
Nat Biomed Eng. 2018 Feb;2(2):85-94
pubmed: 31015628
Nat Commun. 2020 Apr 14;11(1):1771
pubmed: 32286306