Effects of valproic acid on syncytialization in human placental trophoblast cell lines.
Antiepileptic drug
Differentiation
Placenta
Syncytialization
Trophoblast
Valproic Acid
Journal
Toxicology and applied pharmacology
ISSN: 1096-0333
Titre abrégé: Toxicol Appl Pharmacol
Pays: United States
ID NLM: 0416575
Informations de publication
Date de publication:
01 09 2023
01 09 2023
Historique:
received:
19
03
2023
revised:
25
06
2023
accepted:
26
06
2023
medline:
7
8
2023
pubmed:
30
6
2023
entrez:
29
6
2023
Statut:
ppublish
Résumé
The placenta is a critical organ for fetal development and a healthy pregnancy, and has multifaceted functions (e.g., substance exchange and hormone secretion). Syncytialization of trophoblasts is important for maintaining placental functions. Epilepsy is one of the most common neurological conditions worldwide. Therefore, this study aimed to reveal the influence of antiepileptic drugs, including valproic acid (VPA), carbamazepine, lamotrigine, gabapentin, levetiracetam, topiramate, lacosamide, and clobazam, at clinically relevant concentrations on syncytialization using in vitro models of trophoblasts. To induce differentiation into syncytiotrophoblast-like cells, BeWo cells were treated with forskolin. Exposure to VPA was found to dose-dependently influence syncytialization-associated genes (ERVW-1, ERVFRD-1, GJA1, CGB, CSH, SLC1A5, and ABCC4) in differentiated BeWo cells. Herein, the biomarkers between differentiated BeWo cells and the human trophoblast stem model (TS
Identifiants
pubmed: 37385477
pii: S0041-008X(23)00250-8
doi: 10.1016/j.taap.2023.116611
pii:
doi:
Substances chimiques
Valproic Acid
614OI1Z5WI
Anticonvulsants
0
ATP-Binding Cassette Transporters
0
SLC1A5 protein, human
0
Minor Histocompatibility Antigens
0
Amino Acid Transport System ASC
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
116611Informations de copyright
Copyright © 2023 Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors report no conflicts of interest.