The effect of duloxetine on female sexual functions in the treatment of stress incontinence.
Female
Humans
Middle Aged
Duloxetine Hydrochloride
/ therapeutic use
Norepinephrine
Quality of Life
Selective Serotonin Reuptake Inhibitors
/ therapeutic use
Serotonin and Noradrenaline Reuptake Inhibitors
/ therapeutic use
Urinary Incontinence, Stress
/ drug therapy
Sexual Dysfunction, Physiological
Duloxetine
Sexual dysfunction
Stress urinary incontinence
Urinary incontinence
Journal
Archives of gynecology and obstetrics
ISSN: 1432-0711
Titre abrégé: Arch Gynecol Obstet
Pays: Germany
ID NLM: 8710213
Informations de publication
Date de publication:
09 2023
09 2023
Historique:
received:
24
04
2023
accepted:
21
06
2023
medline:
17
7
2023
pubmed:
30
6
2023
entrez:
29
6
2023
Statut:
ppublish
Résumé
Stress urinary incontinence (SUI) is defined as urinary incontinence that occurs with coughing, sneezing, and physical exercise. It is frequently observed in women after middle age and has a negative impact on their sexual function. Duloxetine as one of the Serotonin-noradrenaline reuptake inhibitors (SNRIs) is commonly used in the non-surgical treatment of SUI. The aim of our study is to investigate the effect of duloxetine, which is used in the treatment of SUI, on sexual functions in female patients. The study included 40 sexually active patients who received duloxetine 40 mg twice a day for the treatment of SUI. All patients had female sexual function index (FSFI), Beck's depression inventory (BDI), and incontinence quality of life score (I-QOL) applied before and 2 months after starting duloxetine treatment. FSFI total score significantly increased from 19.9 to 25.7 (p < 0.001). In addition, significant improvement was observed in all sub-parameters of FSFI, including arousal, lubrication, orgasm, satisfaction, and pain/discomfort (p < 0.001, for each FSFI subtotal score). BDI significantly decreased from 4.5 to 1.5 (p < 0.001). I-QOL score significantly increased from 57.6 to 92.7 after the duloxetine treatment. Although SNRIs carry a high risk of sexual dysfunction, duloxetine may have an indirect positive effect on female sexual activity, both through its stress incontinence treatment and its antidepressant effect. In our study, Duloxetine, one of the treatment options for stress urinary incontinence and an SNRI, has a positive effect on stress urinary incontinence, mental health, and sexual activity in patients with SUI.
Identifiants
pubmed: 37386151
doi: 10.1007/s00404-023-07123-4
pii: 10.1007/s00404-023-07123-4
doi:
Substances chimiques
Duloxetine Hydrochloride
9044SC542W
Norepinephrine
X4W3ENH1CV
Selective Serotonin Reuptake Inhibitors
0
Serotonin and Noradrenaline Reuptake Inhibitors
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1037-1042Informations de copyright
© 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
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