Sphingosine 1-phosphate elicits a ROS-mediated proinflammatory response in human endometrial stromal cells via ERK5 activation.
MAPK
MAPK7
MEK5
SRC family kinases
bioactive sphingolipids
endometriosis
inflammation
oxidative stress
sphingosine 1-phosphate receptors
Journal
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
ISSN: 1530-6860
Titre abrégé: FASEB J
Pays: United States
ID NLM: 8804484
Informations de publication
Date de publication:
Aug 2023
Aug 2023
Historique:
revised:
09
06
2023
received:
21
02
2023
accepted:
14
06
2023
medline:
3
7
2023
pubmed:
30
6
2023
entrez:
30
6
2023
Statut:
ppublish
Résumé
Endometriosis is a chronic gynecological disease affecting ~10% women in the reproductive age characterized by the growth of endometrial glands and stroma outside the uterine cavity. The inflammatory process has a key role in the initiation and progression of the disorder. Currently, there are no available early diagnostic tests and therapy relies exclusively on symptomatic drugs, so that elucidation of the complex molecular mechanisms involved in the pathogenesis of endometriosis is an unmet need. The signaling of the bioactive sphingolipid sphingosine 1-phosphate (S1P) is deeply dysregulated in endometriosis. S1P modulates a variety of fundamental cellular processes, including inflammation, neo-angiogenesis, and immune responses acting mainly as ligand of a family of G-protein-coupled receptors named S1P receptors (S1PR), S1P
Identifiants
pubmed: 37389926
doi: 10.1096/fj.202300323R
doi:
Substances chimiques
sphingosine 1-phosphate
26993-30-6
Reactive Oxygen Species
0
Sphingosine
NGZ37HRE42
Sphingolipids
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e23061Subventions
Organisme : Ente Cassa di Risparmio di Firenze (Cash Savings Institution of Florence)
Organisme : Fondazione AIRC per la ricerca sul cancro ETS (AIRC)
Organisme : Ministero dell'Istruzione, dell'Università e della Ricerca (MIUR)
Organisme : Università degli Studi di Firenze (UniFI)
Informations de copyright
© 2023 The Authors. The FASEB Journal published by Wiley Periodicals LLC on behalf of Federation of American Societies for Experimental Biology.
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