A conserved tryptophan in the acylated segment of RTX toxins controls their β

Adenylate Cyclase Toxin / chemistry Bordetella pertussis CD18 Antigens / genetics Cell Membrane / metabolism Erythrocytes / metabolism Tryptophan / chemistry Conserved Sequence
RTX toxin acylated segment adenylate cyclase toxin cytotoxicity hydrogen/deuterium exchange thermal stability tryptophan residue α-hemolysin β(2) integrins

Journal

The Journal of biological chemistry
ISSN: 1083-351X
Titre abrégé: J Biol Chem
Pays: United States
ID NLM: 2985121R

Informations de publication

Date de publication:
08 2023
Historique:
received: 19 04 2023
revised: 20 06 2023
accepted: 22 06 2023
medline: 31 8 2023
pubmed: 1 7 2023
entrez: 30 6 2023
Statut: ppublish

Résumé

The acylated Repeats in ToXins (RTX) leukotoxins, the adenylate cyclase toxin (CyaA) or α-hemolysin (HlyA), bind β

Identifiants

DOI: 10.1016/j.jbc.2023.104978 PMID: 37390987 PMC: PMC10392135
pubmed: 37390987
pii: S0021-9258(23)02006-9
doi: 10.1016/j.jbc.2023.104978
pmc: PMC10392135
pii:
doi:

Substances chimiques

Adenylate Cyclase Toxin 0
CD18 Antigens 0
Tryptophan 8DUH1N11BX

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

104978

Informations de copyright

Copyright © 2023 The Authors. Published by Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Conflict of interest The authors declare that they have no conflict of interest with the contents of this article.

Auteurs

Adriana Osickova (A)

Institute of Microbiology of the Czech Academy of Sciences, Prague, Czech Republic.

Sarka Knoblochova (S)

Institute of Microbiology of the Czech Academy of Sciences, Prague, Czech Republic.

Ladislav Bumba (L)

Institute of Microbiology of the Czech Academy of Sciences, Prague, Czech Republic.

Petr Man (P)

Institute of Microbiology of the Czech Academy of Sciences, Prague, Czech Republic.

Zuzana Kalaninova (Z)

Institute of Microbiology of the Czech Academy of Sciences, Prague, Czech Republic; Faculty of Sciences, Charles University, Prague, Czech Republic.

Anna Lepesheva (A)

Institute of Microbiology of the Czech Academy of Sciences, Prague, Czech Republic; Faculty of Sciences, Charles University, Prague, Czech Republic.

David Jurnecka (D)

Institute of Microbiology of the Czech Academy of Sciences, Prague, Czech Republic.

Monika Cizkova (M)

Institute of Microbiology of the Czech Academy of Sciences, Prague, Czech Republic.

Lada Biedermannova (L)

Institute of Biotechnology of the Czech Academy of Sciences, BIOCEV, Vestec, Czech Republic.

Jory A Goldsmith (JA)

Department of Molecular Biosciences, The University of Texas at Austin, Austin, USA.

Jennifer A Maynard (JA)

Department of Chemical Engineering, The University of Texas at Austin, Austin, USA.

Jason S McLellan (JS)

Department of Molecular Biosciences, The University of Texas at Austin, Austin, USA.

Radim Osicka (R)

Institute of Microbiology of the Czech Academy of Sciences, Prague, Czech Republic.

Peter Sebo (P)

Institute of Microbiology of the Czech Academy of Sciences, Prague, Czech Republic. Electronic address: sebo@biomed.cas.cz.

Jiri Masin (J)

Institute of Microbiology of the Czech Academy of Sciences, Prague, Czech Republic. Electronic address: masin@biomed.cas.cz.

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Classifications MeSH

questionsmedicales.fr › Facteurs biologiques › Toxines biologiques › Facteurs de virulence › Facteurs de virulence des Bordetella › Toxine d'adénylate cyclase › A conserved tryptophan in the acylated segment...
questionsmedicales.fr › Bactéries › Proteobacteria › Betaproteobacteria › Burkholderiales › Alcaligenaceae › Bordetella › Bordetella pertussis › A conserved tryptophan in the acylated segment...
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Antigènes de différenciation › Antigènes de différenciation des lymphocytes T › Antigènes CD18 › A conserved tryptophan in the acylated segment...
questionsmedicales.fr › Cellules › Structures cellulaires › Membrane cellulaire › A conserved tryptophan in the acylated segment...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Sang › Cellules sanguines › Érythrocytes › A conserved tryptophan in the acylated segment...
questionsmedicales.fr › Acides aminés, peptides et protéines › Acides aminés › Acides aminés essentiels › Tryptophane › A conserved tryptophan in the acylated segment...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Séquence conservée › A conserved tryptophan in the acylated segment...