Post-Transcriptional and Epigenetic Regulation of Estrogen Signaling.

Female Humans Endothelial Cells / metabolism Epigenesis, Genetic Estrogens Estradiol / metabolism Receptors, G-Protein-Coupled / metabolism MicroRNAs / genetics Neoplasms

Journal

The Journal of pharmacology and experimental therapeutics
ISSN: 1521-0103
Titre abrégé: J Pharmacol Exp Ther
Pays: United States
ID NLM: 0376362

Informations de publication

Date de publication:
09 2023
Historique:
received: 07 02 2023
accepted: 16 06 2023
medline: 21 8 2023
pubmed: 1 7 2023
entrez: 30 6 2023
Statut: ppublish

Résumé

Post-translational and epigenetic regulation are important mechanisms controlling functions of genes and proteins. Although the "classic" estrogen receptors (ERs) have been acknowledged to function in mediating estrogen effects via transcriptional mechanisms, estrogenic agents modulate the turnover of several proteins via post-transcriptional and post-translational pathways including epigenetics. For instance, the metabolic and angiogenic action of G-protein coupled estrogen receptor (GPER) in vascular endothelial cells has been recently elucidated. By interacting with GPER, 17

Identifiants

DOI: 10.1124/jpet.123.001613 PMID: 37391222
pubmed: 37391222
pii: jpet.123.001613
doi: 10.1124/jpet.123.001613
doi:

Substances chimiques

Estrogens 0
Estradiol 4TI98Z838E
Receptors, G-Protein-Coupled 0
MicroRNAs 0

Types de publication

Journal Article Review Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

288-297

Informations de copyright

Copyright © 2023 by The Author(s).

Auteurs

Andrea Cignarella (A)

Departments of Medicine (A.C., Ca.B., M.A.) and Pharmaceutical and Pharmacological Sciences (Ch.B.), University of Padova, Padova, Italy; and Molecular Internal Medicine, University of Zürich and Andreas Grüntzig Foundation, Zürich, Switzerland (M.B.) andrea.cignarella@unipd.it.
ORCID: 0000-0002-4820-4876

Carlotta Boscaro (C)

Departments of Medicine (A.C., Ca.B., M.A.) and Pharmaceutical and Pharmacological Sciences (Ch.B.), University of Padova, Padova, Italy; and Molecular Internal Medicine, University of Zürich and Andreas Grüntzig Foundation, Zürich, Switzerland (M.B.).

Mattia Albiero (M)

Departments of Medicine (A.C., Ca.B., M.A.) and Pharmaceutical and Pharmacological Sciences (Ch.B.), University of Padova, Padova, Italy; and Molecular Internal Medicine, University of Zürich and Andreas Grüntzig Foundation, Zürich, Switzerland (M.B.).

Chiara Bolego (C)

Departments of Medicine (A.C., Ca.B., M.A.) and Pharmaceutical and Pharmacological Sciences (Ch.B.), University of Padova, Padova, Italy; and Molecular Internal Medicine, University of Zürich and Andreas Grüntzig Foundation, Zürich, Switzerland (M.B.).

Matthias Barton (M)

Departments of Medicine (A.C., Ca.B., M.A.) and Pharmaceutical and Pharmacological Sciences (Ch.B.), University of Padova, Padova, Italy; and Molecular Internal Medicine, University of Zürich and Andreas Grüntzig Foundation, Zürich, Switzerland (M.B.).

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Post-Transcriptional and Epigenetic Regulation...
questionsmedicales.fr › Cellules › Cellules épithéliales › Cellules endothéliales › Post-Transcriptional and Epigenetic Regulation...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Épigenèse génétique › Post-Transcriptional and Epigenetic Regulation...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Hormones, substituts d'hormones et antagonistes d'hormones › Hormones › Oestrogènes › Post-Transcriptional and Epigenetic Regulation...
questionsmedicales.fr › Hormones gonadiques › Hormones sexuelles stéroïdiennes › Congénères de l'oestradiol › Oestradiol › Post-Transcriptional and Epigenetic Regulation...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs couplés aux protéines G › Post-Transcriptional and Epigenetic Regulation...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ARN › ARN non traduit › Petit ARN non traduit › microARN › Post-Transcriptional and Epigenetic Regulation...
questionsmedicales.fr › Tumeurs › Post-Transcriptional and Epigenetic Regulation...