A formamidopyrimidine derivative from the deoxyguanosine adduct produced by food contaminant acrylamide induces DNA replication block and mutagenesis.
DNA damage
DNA replication
acrylamide
formamidopyrimidine
glycidamide
mutagenesis
mutagenesis mechanism
nucleic acid chemistry
Journal
The Journal of biological chemistry
ISSN: 1083-351X
Titre abrégé: J Biol Chem
Pays: United States
ID NLM: 2985121R
Informations de publication
Date de publication:
08 2023
08 2023
Historique:
received:
23
04
2023
revised:
23
06
2023
accepted:
26
06
2023
medline:
31
8
2023
pubmed:
3
7
2023
entrez:
2
7
2023
Statut:
ppublish
Résumé
Acrylamide, a common food contaminant, is metabolically activated to glycidamide, which reacts with DNA at the N7 position of dG, forming N7-(2-carbamoyl-2-hydroxyethyl)-dG (GA
Identifiants
pubmed: 37394003
pii: S0021-9258(23)02030-6
doi: 10.1016/j.jbc.2023.105002
pmc: PMC10406624
pii:
doi:
Substances chimiques
Acrylamides
0
Deoxyguanosine
G9481N71RO
DNA
9007-49-2
DNA Adducts
0
Mutagens
0
N6-(2-deoxy-erythro-pentofuranosyl)-2,6-diamino-4-hydroxy-5-formamidopyrimidine
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
105002Informations de copyright
Copyright © 2023 The Authors. Published by Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Conflict of interest The authors declare that they have no conflicts of interest with the contents of this article.