Exposure to Therapeutic BTK Inhibitors Induces Phenocopying of
beta-catenin
disease model
drug screens
germ cell proliferation
morphogenesis
non-receptor tyrosine kinase
Journal
Frontiers in bioscience (Landmark edition)
ISSN: 2768-6698
Titre abrégé: Front Biosci (Landmark Ed)
Pays: Singapore
ID NLM: 101612996
Informations de publication
Date de publication:
27 06 2023
27 06 2023
Historique:
received:
19
04
2023
revised:
22
05
2023
accepted:
01
06
2023
medline:
4
7
2023
pubmed:
3
7
2023
entrez:
3
7
2023
Statut:
ppublish
Résumé
Bruton's tyrosine kinase (BTK) is a non-receptor type tyrosine kinase originally identified as the genetic signature responsible for X-linked agammaglobulinemia (XLA) when mutated. Its functional form is required for B lymphocyte maturation in both humans and mice, whereas loss-of-function causes a different form of developmental defect in the fruit fly, Ibrutinib and other therapeutic inhibitors of BTK have been extensively used to successfully treat various leukemias and lymphomas. We have previously reported that Thus,
Sections du résumé
BACKGROUND
Bruton's tyrosine kinase (BTK) is a non-receptor type tyrosine kinase originally identified as the genetic signature responsible for X-linked agammaglobulinemia (XLA) when mutated. Its functional form is required for B lymphocyte maturation in both humans and mice, whereas loss-of-function causes a different form of developmental defect in the fruit fly,
METHODS
Ibrutinib and other therapeutic inhibitors of BTK have been extensively used to successfully treat various leukemias and lymphomas.
RESULTS
We have previously reported that
CONCLUSIONS
Thus,
Identifiants
pubmed: 37395037
pii: S2768-6701(23)00913-9
doi: 10.31083/j.fbl2806124
doi:
Substances chimiques
Protein-Tyrosine Kinases
EC 2.7.10.1
beta Catenin
0
Agammaglobulinaemia Tyrosine Kinase
EC 2.7.10.2
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
124Informations de copyright
© 2023 The Author(s). Published by IMR Press.
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.